HIGD2A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	37 studies	44% ± 14%	Explore
natural killer cell	35 studies	38% ± 12%	Explore
CD8-positive, alpha-beta T cell	34 studies	47% ± 17%	Explore
macrophage	31 studies	50% ± 13%	Explore
CD4-positive, alpha-beta T cell	30 studies	49% ± 13%	Explore
T cell	29 studies	44% ± 14%	Explore
fibroblast	28 studies	34% ± 13%	Explore
conventional dendritic cell	27 studies	65% ± 17%	Explore
regulatory T cell	26 studies	50% ± 16%	Explore
classical monocyte	25 studies	60% ± 15%	Explore
smooth muscle cell	23 studies	33% ± 16%	Explore
non-classical monocyte	23 studies	73% ± 15%	Explore
dendritic cell	22 studies	61% ± 22%	Explore
endothelial cell	22 studies	31% ± 12%	Explore
plasmacytoid dendritic cell	21 studies	53% ± 15%	Explore
memory B cell	20 studies	50% ± 13%	Explore
epithelial cell	20 studies	52% ± 21%	Explore
naive B cell	19 studies	35% ± 11%	Explore
basal cell	19 studies	48% ± 20%	Explore
pericyte	19 studies	33% ± 13%	Explore
monocyte	18 studies	56% ± 13%	Explore
gamma-delta T cell	18 studies	43% ± 16%	Explore
mature NK T cell	18 studies	42% ± 12%	Explore
mast cell	17 studies	35% ± 13%	Explore
endothelial cell of lymphatic vessel	16 studies	38% ± 12%	Explore
mucosal invariant T cell	15 studies	41% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	47% ± 13%	Explore
plasma cell	15 studies	47% ± 13%	Explore
ciliated cell	15 studies	47% ± 17%	Explore
connective tissue cell	15 studies	40% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	38% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	43% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	55% ± 14%	Explore
myofibroblast cell	13 studies	38% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	46% ± 22%	Explore
myeloid cell	12 studies	52% ± 19%	Explore
plasmablast	11 studies	49% ± 21%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	49% ± 20%	Explore
secretory cell	10 studies	49% ± 18%	Explore
progenitor cell	10 studies	52% ± 18%	Explore
goblet cell	10 studies	48% ± 19%	Explore
vein endothelial cell	10 studies	25% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	48% ± 15%	Explore
abnormal cell	9 studies	45% ± 20%	Explore
endothelial cell of artery	9 studies	23% ± 8%	Explore
endothelial cell of vascular tree	9 studies	25% ± 6%	Explore
innate lymphoid cell	8 studies	33% ± 11%	Explore
leukocyte	8 studies	46% ± 13%	Explore
mesothelial cell	8 studies	57% ± 19%	Explore
T follicular helper cell	8 studies	50% ± 10%	Explore
type I pneumocyte	7 studies	35% ± 15%	Explore
club cell	7 studies	49% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	54% ± 19%	Explore
epithelial cell of proximal tubule	7 studies	39% ± 12%	Explore
capillary endothelial cell	7 studies	25% ± 10%	Explore
enterocyte	7 studies	38% ± 12%	Explore
type II pneumocyte	6 studies	43% ± 18%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	62% ± 25%	Explore
kidney loop of Henle epithelial cell	6 studies	36% ± 8%	Explore
neutrophil	6 studies	30% ± 11%	Explore
renal alpha-intercalated cell	6 studies	58% ± 8%	Explore
intestinal crypt stem cell	6 studies	47% ± 20%	Explore
hematopoietic stem cell	6 studies	48% ± 18%	Explore
precursor B cell	6 studies	40% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	56% ± 21%	Explore
alveolar macrophage	5 studies	52% ± 10%	Explore
CD4-positive helper T cell	5 studies	33% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	44% ± 14%	Explore
hematopoietic precursor cell	5 studies	53% ± 20%	Explore
exhausted T cell	5 studies	63% ± 11%	Explore
ionocyte	5 studies	50% ± 16%	Explore
respiratory goblet cell	5 studies	47% ± 16%	Explore
mononuclear phagocyte	5 studies	58% ± 18%	Explore
enteroendocrine cell	5 studies	50% ± 19%	Explore
transit amplifying cell	5 studies	44% ± 20%	Explore
brush cell	5 studies	33% ± 18%	Explore
T-helper 17 cell	5 studies	50% ± 13%	Explore
immature B cell	5 studies	55% ± 8%	Explore
double negative thymocyte	5 studies	60% ± 13%	Explore
intermediate monocyte	5 studies	76% ± 13%	Explore
granulocyte	5 studies	34% ± 9%	Explore
erythrocyte	5 studies	39% ± 15%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	42% ± 17%	Explore
pancreatic A cell	4 studies	50% ± 10%	Explore
type B pancreatic cell	4 studies	42% ± 17%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	53% ± 7%	Explore
retinal ganglion cell	4 studies	52% ± 29%	Explore
pro-B cell	4 studies	41% ± 15%	Explore
neuron	4 studies	54% ± 14%	Explore
retina horizontal cell	4 studies	33% ± 16%	Explore
adventitial cell	4 studies	21% ± 6%	Explore
mucus secreting cell	4 studies	40% ± 21%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	34% ± 10%	Explore
T-helper 1 cell	4 studies	57% ± 11%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	56% ± 21%	Explore
deuterosomal cell	3 studies	40% ± 9%	Explore
duct epithelial cell	3 studies	46% ± 12%	Explore
precursor cell	3 studies	54% ± 5%	Explore
platelet	3 studies	28% ± 14%	Explore
monocyte-derived dendritic cell	3 studies	61% ± 31%	Explore
neural crest cell	3 studies	40% ± 4%	Explore
IgG plasma cell	3 studies	29% ± 12%	Explore
common myeloid progenitor	3 studies	53% ± 25%	Explore
erythroblast	3 studies	43% ± 14%	Explore
lymphocyte	3 studies	49% ± 16%	Explore
neuroendocrine cell	3 studies	50% ± 22%	Explore
amacrine cell	3 studies	41% ± 11%	Explore
retinal cone cell	3 studies	48% ± 20%	Explore
microglial cell	3 studies	37% ± 17%	Explore
serous secreting cell	3 studies	50% ± 4%	Explore
intraepithelial lymphocyte	3 studies	44% ± 11%	Explore
Mueller cell	3 studies	27% ± 9%	Explore
muscle cell	3 studies	31% ± 16%	Explore
germinal center B cell	3 studies	50% ± 4%	Explore
myoepithelial cell	3 studies	35% ± 14%	Explore
pancreatic ductal cell	3 studies	54% ± 8%	Explore
granulocyte monocyte progenitor cell	3 studies	46% ± 16%	Explore
hepatocyte	3 studies	45% ± 32%	Explore
group 3 innate lymphoid cell	3 studies	44% ± 17%	Explore
keratinocyte	3 studies	31% ± 4%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	55% ± 15%	Explore
progenitor cell of mammary luminal epithelium	3 studies	38% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	52% ± 12%	Explore
lung	16 studies	45% ± 16%	Explore
intestine	12 studies	37% ± 16%	Explore
kidney	8 studies	42% ± 11%	Explore
eye	6 studies	26% ± 10%	Explore
pancreas	5 studies	40% ± 18%	Explore
liver	5 studies	39% ± 15%	Explore
lymph node	5 studies	45% ± 19%	Explore
bone marrow	4 studies	33% ± 18%	Explore
uterus	4 studies	45% ± 16%	Explore
breast	4 studies	34% ± 10%	Explore
adrenal gland	3 studies	41% ± 12%	Explore
esophagus	3 studies	43% ± 26%	Explore
placenta	3 studies	29% ± 16%	Explore
prostate	3 studies	36% ± 13%	Explore
brain	3 studies	31% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	2983.31	258 / 258	100%	305.43	230 / 230
bladder	100%	2707.81	21 / 21	100%	230.15	504 / 504
esophagus	100%	2660.20	1445 / 1445	100%	198.01	183 / 183
intestine	100%	3191.97	966 / 966	100%	286.40	527 / 527
liver	100%	1573.95	226 / 226	100%	216.60	406 / 406
ovary	100%	1979.05	180 / 180	100%	531.51	430 / 430
skin	100%	2145.59	1809 / 1809	100%	246.81	472 / 472
stomach	100%	2073.26	359 / 359	100%	265.01	286 / 286
thymus	100%	2173.82	653 / 653	100%	204.98	605 / 605
uterus	100%	1788.49	170 / 170	100%	235.49	459 / 459
prostate	100%	2377.29	245 / 245	100%	224.84	501 / 502
brain	100%	1887.82	2640 / 2642	100%	189.95	704 / 705
kidney	100%	2846.07	89 / 89	100%	219.44	899 / 901
lung	100%	1748.27	576 / 578	100%	162.98	1153 / 1155
pancreas	99%	1063.40	325 / 328	100%	186.22	178 / 178
breast	100%	2003.15	459 / 459	99%	182.96	1107 / 1118
adipose	100%	2241.67	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	443.60	80 / 80
lymph node	0%	0	0 / 0	100%	406.98	29 / 29
muscle	100%	4069.04	803 / 803	0%	0	0 / 0
spleen	100%	2282.39	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	208.93	45 / 45
ureter	0%	0	0 / 0	100%	119.43	1 / 1
blood vessel	100%	1401.49	1331 / 1335	0%	0	0 / 0
heart	100%	3139.87	857 / 861	0%	0	0 / 0
peripheral blood	99%	2226.08	918 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0097250	Biological process	mitochondrial respirasome assembly
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0070469	Cellular component	respirasome
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion

Gene name	HIGD2A
Protein name	HIG1 domain family member 2A, mitochondrial (RCF1 homolog B) (RCF1b)
Synonyms
Description	FUNCTION: Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes. .
Accessions	Q9BW72 ENST00000274787.3

HIGD2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review