LEF1 | OmnibusX

Name	Number of supported studies	Average coverage
CD4-positive, alpha-beta T cell	23 studies	39% ± 21%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	19 studies	46% ± 15%	Explore
regulatory T cell	19 studies	38% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	49% ± 15%	Explore
endothelial cell	13 studies	46% ± 22%	Explore
T cell	11 studies	33% ± 18%	Explore
CD8-positive, alpha-beta T cell	7 studies	57% ± 26%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	34% ± 13%	Explore
T follicular helper cell	5 studies	33% ± 16%	Explore
pericyte	4 studies	32% ± 10%	Explore
pro-B cell	4 studies	52% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	25% ± 3%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	27% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	30% ± 17%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	41% ± 2%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	40% ± 14%	Explore
double negative thymocyte	3 studies	49% ± 27%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	12 studies	22% ± 7%	Explore
lymph node	3 studies	26% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	99%	605.96	2605 / 2642	90%	10.63	635 / 705
breast	90%	419.65	415 / 459	91%	18.36	1021 / 1118
lung	99%	535.72	573 / 578	77%	9.77	888 / 1155
thymus	94%	597.84	616 / 653	80%	55.26	486 / 605
prostate	99%	582.17	242 / 245	75%	8.33	375 / 502
skin	73%	340.55	1326 / 1809	97%	79.31	456 / 472
ovary	76%	225.50	136 / 180	85%	20.55	364 / 430
uterus	99%	850.21	169 / 170	56%	10.83	259 / 459
kidney	98%	582.62	87 / 89	41%	5.57	371 / 901
intestine	59%	355.66	572 / 966	76%	9.44	403 / 527
adrenal gland	100%	2078.42	257 / 258	34%	9.13	78 / 230
esophagus	50%	254.20	728 / 1445	80%	12.62	147 / 183
bladder	71%	428.14	15 / 21	52%	5.59	263 / 504
stomach	36%	68.67	131 / 359	77%	8.88	221 / 286
spleen	100%	1075.96	241 / 241	0%	0	0 / 0
peripheral blood	95%	1281.36	884 / 929	0%	0	0 / 0
pancreas	5%	8.96	15 / 328	87%	13.63	155 / 178
lymph node	0%	0	0 / 0	86%	18.73	25 / 29
tonsil	0%	0	0 / 0	76%	7.32	34 / 45
adipose	61%	147.71	740 / 1204	0%	0	0 / 0
liver	2%	2.48	4 / 226	30%	3.14	121 / 406
blood vessel	20%	56.10	266 / 1335	0%	0	0 / 0
heart	6%	12.45	49 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	5%	0.23	4 / 80
muscle	0%	1.22	3 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006366	Biological process	transcription by RNA polymerase II
GO_0030509	Biological process	BMP signaling pathway
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0032696	Biological process	negative regulation of interleukin-13 production
GO_1902262	Biological process	apoptotic process involved in blood vessel morphogenesis
GO_0060033	Biological process	anatomical structure regression
GO_0050767	Biological process	regulation of neurogenesis
GO_0060326	Biological process	cell chemotaxis
GO_0071866	Biological process	negative regulation of apoptotic process in bone marrow cell
GO_0042475	Biological process	odontogenesis of dentin-containing tooth
GO_0030879	Biological process	mammary gland development
GO_1901331	Biological process	positive regulation of odontoblast differentiation
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0001649	Biological process	osteoblast differentiation
GO_0010628	Biological process	positive regulation of gene expression
GO_0060710	Biological process	chorio-allantoic fusion
GO_0045588	Biological process	positive regulation of gamma-delta T cell differentiation
GO_0021873	Biological process	forebrain neuroblast division
GO_0071345	Biological process	cellular response to cytokine stimulus
GO_0043923	Biological process	positive regulation by host of viral transcription
GO_0030326	Biological process	embryonic limb morphogenesis
GO_0043392	Biological process	negative regulation of DNA binding
GO_0045843	Biological process	negative regulation of striated muscle tissue development
GO_0030177	Biological process	positive regulation of Wnt signaling pathway
GO_0045063	Biological process	T-helper 1 cell differentiation
GO_0030223	Biological process	neutrophil differentiation
GO_0048341	Biological process	paraxial mesoderm formation
GO_0021542	Biological process	dentate gyrus development
GO_0043586	Biological process	tongue development
GO_0050909	Biological process	sensory perception of taste
GO_0002040	Biological process	sprouting angiogenesis
GO_0021861	Biological process	forebrain radial glial cell differentiation
GO_0001569	Biological process	branching involved in blood vessel morphogenesis
GO_0045597	Biological process	positive regulation of cell differentiation
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_1902732	Biological process	positive regulation of chondrocyte proliferation
GO_0001756	Biological process	somitogenesis
GO_0021943	Biological process	formation of radial glial scaffolds
GO_0071168	Biological process	protein localization to chromatin
GO_1904019	Biological process	epithelial cell apoptotic process
GO_0042100	Biological process	B cell proliferation
GO_0032714	Biological process	negative regulation of interleukin-5 production
GO_0060325	Biological process	face morphogenesis
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0061153	Biological process	trachea gland development
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0001837	Biological process	epithelial to mesenchymal transition
GO_0030854	Biological process	positive regulation of granulocyte differentiation
GO_0033153	Biological process	T cell receptor V(D)J recombination
GO_0062009	Biological process	secondary palate development
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0071353	Biological process	cellular response to interleukin-4
GO_0060070	Biological process	canonical Wnt signaling pathway
GO_0071864	Biological process	positive regulation of cell proliferation in bone marrow
GO_0030335	Biological process	positive regulation of cell migration
GO_0032713	Biological process	negative regulation of interleukin-4 production
GO_0010718	Biological process	positive regulation of epithelial to mesenchymal transition
GO_0032993	Cellular component	protein-DNA complex
GO_0005634	Cellular component	nucleus
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_1990907	Cellular component	beta-catenin-TCF complex
GO_0000785	Cellular component	chromatin
GO_0005667	Cellular component	transcription regulator complex
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001222	Molecular function	transcription corepressor binding
GO_0045295	Molecular function	gamma-catenin binding
GO_0070742	Molecular function	C2H2 zinc finger domain binding
GO_0070016	Molecular function	armadillo repeat domain binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0043565	Molecular function	sequence-specific DNA binding
GO_0003682	Molecular function	chromatin binding
GO_0042393	Molecular function	histone binding
GO_0140416	Molecular function	transcription regulator inhibitor activity
GO_0042826	Molecular function	histone deacetylase binding
GO_0030331	Molecular function	nuclear estrogen receptor binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0005515	Molecular function	protein binding
GO_0003677	Molecular function	DNA binding
GO_0008301	Molecular function	DNA binding, bending
GO_0000977	Molecular function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0008013	Molecular function	beta-catenin binding

IV. Literature review

[source]

Gene name	LEF1
Protein name	Lymphoid enhancer binding factor 1 Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1-alpha) Lymphoid enhancer-binding factor 1
Synonyms
Description	FUNCTION: Transcription factor that binds DNA in a sequence-specific manner . Participates in the Wnt signaling pathway (By similarity). Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity). PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 . Regulates T-cell receptor alpha enhancer function . Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity). May play a role in hair cell differentiation and follicle morphogenesis (By similarity). .; FUNCTION: [Isoform 1]: Transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. .; FUNCTION: [Isoform 3]: Lacks the CTNNB1 interaction domain and may therefore be an antagonist for Wnt signaling. .; FUNCTION: [Isoform 5]: Transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. .
Accessions	ENST00000379951.6 [Q9UJU2-6] ENST00000265165.6 [Q9UJU2-1] D6RAB1 D6RIV1 D6RID7 Q9UJU2 ENST00000515500.5 ENST00000506680.5 [Q9UJU2-2] G9G139 ENST00000510624.5 [Q9UJU2-7] ENST00000504950.5 ENST00000438313.6 [Q9UJU2-5] ENST00000512172.1

LEF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review