GATA6 | OmnibusX

Name	Number of supported studies	Average coverage
fibroblast	9 studies	25% ± 8%	Explore
mesothelial cell	6 studies	36% ± 12%	Explore
cardiac muscle cell	5 studies	36% ± 5%	Explore
type I pneumocyte	5 studies	22% ± 5%	Explore
epithelial cell	4 studies	32% ± 14%	Explore
smooth muscle cell	4 studies	20% ± 3%	Explore
goblet cell	4 studies	24% ± 8%	Explore
pancreatic A cell	3 studies	18% ± 2%	Explore
hepatic stellate cell	3 studies	30% ± 11%	Explore
enteroendocrine cell	3 studies	18% ± 2%	Explore
intestinal crypt stem cell	3 studies	21% ± 3%	Explore
endothelial cell of artery	3 studies	22% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
heart	4 studies	20% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	100%	1811.70	328 / 328	93%	27.98	166 / 178
ovary	100%	10107.85	180 / 180	91%	33.86	391 / 430
stomach	91%	4039.84	328 / 359	99%	52.83	282 / 286
liver	95%	953.82	215 / 226	82%	8.98	332 / 406
thymus	92%	831.53	603 / 653	77%	6.98	467 / 605
intestine	68%	1083.03	660 / 966	99%	42.14	520 / 527
lung	99%	2202.31	574 / 578	65%	14.03	746 / 1155
adrenal gland	100%	7797.58	258 / 258	55%	18.60	127 / 230
bladder	100%	3265.62	21 / 21	50%	9.81	253 / 504
uterus	96%	3088.98	164 / 170	42%	5.81	192 / 459
breast	69%	485.66	319 / 459	47%	4.04	527 / 1118
esophagus	42%	353.39	612 / 1445	69%	38.07	127 / 183
prostate	52%	753.21	128 / 245	50%	3.41	250 / 502
spleen	100%	2233.61	241 / 241	0%	0	0 / 0
blood vessel	100%	3424.26	1333 / 1335	0%	0	0 / 0
heart	100%	4114.51	859 / 861	0%	0	0 / 0
adipose	77%	1653.77	931 / 1204	0%	0	0 / 0
kidney	38%	295.55	34 / 89	24%	1.81	215 / 901
skin	7%	44.98	135 / 1809	22%	1.81	103 / 472
tonsil	0%	0	0 / 0	22%	1.29	10 / 45
brain	0%	0.90	2 / 2642	2%	0.19	12 / 705
muscle	1%	4.34	5 / 803	0%	0	0 / 0
peripheral blood	1%	2.77	5 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0042475	Biological process	odontogenesis of dentin-containing tooth
GO_0003309	Biological process	type B pancreatic cell differentiation
GO_0071371	Biological process	cellular response to gonadotropin stimulus
GO_0003148	Biological process	outflow tract septum morphogenesis
GO_0110024	Biological process	positive regulation of cardiac muscle myoblast proliferation
GO_0043627	Biological process	response to estrogen
GO_0071773	Biological process	cellular response to BMP stimulus
GO_0001701	Biological process	in utero embryonic development
GO_0060045	Biological process	positive regulation of cardiac muscle cell proliferation
GO_0030855	Biological process	epithelial cell differentiation
GO_0045766	Biological process	positive regulation of angiogenesis
GO_0014898	Biological process	cardiac muscle hypertrophy in response to stress
GO_0055007	Biological process	cardiac muscle cell differentiation
GO_0060510	Biological process	type II pneumocyte differentiation
GO_0007493	Biological process	endodermal cell fate determination
GO_1904003	Biological process	negative regulation of sebum secreting cell proliferation
GO_0071456	Biological process	cellular response to hypoxia
GO_1902894	Biological process	negative regulation of miRNA transcription
GO_0060430	Biological process	lung saccule development
GO_0048645	Biological process	animal organ formation
GO_0001889	Biological process	liver development
GO_0003310	Biological process	pancreatic A cell differentiation
GO_0010666	Biological process	positive regulation of cardiac muscle cell apoptotic process
GO_0032911	Biological process	negative regulation of transforming growth factor beta1 production
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0060947	Biological process	cardiac vascular smooth muscle cell differentiation
GO_0060038	Biological process	cardiac muscle cell proliferation
GO_0032912	Biological process	negative regulation of transforming growth factor beta2 production
GO_0098773	Biological process	skin epidermis development
GO_0051591	Biological process	response to cAMP
GO_0060486	Biological process	club cell differentiation
GO_0045165	Biological process	cell fate commitment
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0035239	Biological process	tube morphogenesis
GO_0060047	Biological process	heart contraction
GO_0051145	Biological process	smooth muscle cell differentiation
GO_0030513	Biological process	positive regulation of BMP signaling pathway
GO_0070315	Biological process	G1 to G0 transition involved in cell differentiation
GO_0036302	Biological process	atrioventricular canal development
GO_0008584	Biological process	male gonad development
GO_0003163	Biological process	sinoatrial node development
GO_0006644	Biological process	phospholipid metabolic process
GO_0032526	Biological process	response to retinoic acid
GO_0010467	Biological process	gene expression
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0009636	Biological process	response to toxic substance
GO_0003162	Biological process	atrioventricular node development
GO_0048863	Biological process	stem cell differentiation
GO_0060575	Biological process	intestinal epithelial cell differentiation
GO_0070848	Biological process	response to growth factor
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0001949	Biological process	sebaceous gland cell differentiation
GO_0002759	Biological process	regulation of antimicrobial humoral response
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005654	Cellular component	nucleoplasm
GO_0000785	Cellular component	chromatin
GO_0031965	Cellular component	nuclear membrane
GO_0005667	Cellular component	transcription regulator complex
GO_0005634	Cellular component	nucleus
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297	Molecular function	DNA-binding transcription factor binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003682	Molecular function	chromatin binding
GO_0000976	Molecular function	transcription cis-regulatory region binding
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0019901	Molecular function	protein kinase binding
GO_0001223	Molecular function	transcription coactivator binding
GO_0051525	Molecular function	NFAT protein binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0008270	Molecular function	zinc ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	GATA6
Protein name	Transcription factor GATA-6 (GATA-binding factor 6) GATA6 protein
Synonyms
Description	FUNCTION: Transcriptional activator . Regulates SEMA3C and PLXNA2 . Involved in gene regulation specifically in the gastric epithelium . May regulate genes that protect epithelial cells from bacterial infection . Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). In human skin, controls several physiological processes contributing to homeostasis of the upper pilosebaceous unit. Triggers ductal and sebaceous differentiation as well as limits cell proliferation and lipid production to prevent hyperseborrhoea. Mediates the effects of retinoic acid on sebocyte proliferation, differentiation and lipid production. Also contributes to immune regulation of sebocytes and antimicrobial responses by modulating the expression of anti-inflammatory genes such as IL10 and pro-inflammatory genes such as IL6, TLR2, TLR4, and IFNG. Activates TGFB1 signaling which controls the interfollicular epidermis fate . .
Accessions	Q92908 ENST00000581694.1 [Q92908-1] ENST00000269216.10 [Q92908-1] Q05CA6

GATA6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review