CCND2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	33 studies	26% ± 10%	Explore
fibroblast	24 studies	31% ± 16%	Explore
regulatory T cell	23 studies	31% ± 14%	Explore
CD4-positive, alpha-beta T cell	22 studies	28% ± 13%	Explore
CD8-positive, alpha-beta T cell	22 studies	28% ± 13%	Explore
T cell	20 studies	24% ± 11%	Explore
pericyte	17 studies	29% ± 10%	Explore
smooth muscle cell	14 studies	36% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	26% ± 7%	Explore
mature NK T cell	13 studies	26% ± 9%	Explore
gamma-delta T cell	13 studies	29% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	30% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	23% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	20% ± 5%	Explore
endothelial cell	11 studies	27% ± 9%	Explore
oligodendrocyte precursor cell	11 studies	30% ± 12%	Explore
mucosal invariant T cell	11 studies	22% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	24% ± 8%	Explore
connective tissue cell	10 studies	31% ± 12%	Explore
progenitor cell	9 studies	31% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	28% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	34% ± 22%	Explore
goblet cell	7 studies	29% ± 11%	Explore
mesothelial cell	7 studies	26% ± 14%	Explore
glutamatergic neuron	7 studies	37% ± 19%	Explore
plasmablast	6 studies	54% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	25% ± 6%	Explore
innate lymphoid cell	6 studies	25% ± 8%	Explore
basal cell	6 studies	27% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	24% ± 7%	Explore
GABAergic neuron	6 studies	35% ± 14%	Explore
interneuron	6 studies	32% ± 11%	Explore
type I pneumocyte	5 studies	20% ± 3%	Explore
hematopoietic precursor cell	5 studies	36% ± 15%	Explore
leukocyte	5 studies	22% ± 4%	Explore
abnormal cell	5 studies	33% ± 13%	Explore
intestinal crypt stem cell	5 studies	35% ± 11%	Explore
myofibroblast cell	5 studies	42% ± 16%	Explore
epithelial cell	5 studies	33% ± 15%	Explore
T follicular helper cell	5 studies	21% ± 4%	Explore
mast cell	4 studies	29% ± 22%	Explore
plasma cell	4 studies	33% ± 15%	Explore
exhausted T cell	4 studies	36% ± 16%	Explore
neuron	4 studies	25% ± 11%	Explore
transit amplifying cell	4 studies	25% ± 9%	Explore
microglial cell	4 studies	21% ± 3%	Explore
cardiac muscle cell	4 studies	19% ± 2%	Explore
Mueller cell	4 studies	30% ± 9%	Explore
hematopoietic stem cell	4 studies	30% ± 11%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	42% ± 15%	Explore
T-helper 17 cell	4 studies	31% ± 15%	Explore
macrophage	3 studies	20% ± 2%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	27% ± 9%	Explore
CD4-positive helper T cell	3 studies	27% ± 6%	Explore
myoepithelial cell	3 studies	23% ± 7%	Explore
group 3 innate lymphoid cell	3 studies	35% ± 18%	Explore
astrocyte	3 studies	21% ± 4%	Explore
erythroblast	3 studies	37% ± 22%	Explore
secretory cell	3 studies	22% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	9 studies	30% ± 17%	Explore
lung	7 studies	20% ± 2%	Explore
intestine	7 studies	29% ± 13%	Explore
peripheral blood	4 studies	22% ± 6%	Explore
uterus	4 studies	22% ± 5%	Explore
liver	4 studies	21% ± 2%	Explore
kidney	3 studies	22% ± 0%	Explore
bone marrow	3 studies	27% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	7158.01	653 / 653	97%	143.57	586 / 605
adrenal gland	100%	16193.65	258 / 258	93%	126.68	213 / 230
brain	92%	3647.49	2442 / 2642	99%	121.89	700 / 705
intestine	100%	10849.00	966 / 966	82%	61.23	434 / 527
pancreas	100%	4352.67	327 / 328	72%	27.81	128 / 178
esophagus	100%	6312.43	1441 / 1445	62%	33.39	113 / 183
prostate	100%	7119.66	244 / 245	57%	15.96	287 / 502
lung	100%	5582.32	576 / 578	52%	27.50	599 / 1155
breast	99%	4374.83	454 / 459	47%	12.26	526 / 1118
bladder	100%	8742.48	21 / 21	45%	29.87	228 / 504
stomach	64%	3317.40	230 / 359	79%	58.10	227 / 286
uterus	100%	8837.89	170 / 170	37%	22.38	169 / 459
kidney	47%	1407.78	42 / 89	77%	34.05	692 / 901
ovary	89%	4399.68	160 / 180	27%	21.75	116 / 430
skin	90%	2846.53	1633 / 1809	24%	8.81	113 / 472
spleen	100%	6333.59	241 / 241	0%	0	0 / 0
blood vessel	100%	6818.98	1333 / 1335	0%	0	0 / 0
adipose	100%	4867.07	1199 / 1204	0%	0	0 / 0
heart	99%	9876.36	852 / 861	0%	0	0 / 0
peripheral blood	72%	6930.80	670 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	55%	43.87	16 / 29
tonsil	0%	0	0 / 0	53%	14.08	24 / 45
eye	0%	0	0 / 0	53%	18.08	42 / 80
liver	1%	11.25	2 / 226	6%	2.58	23 / 406
muscle	3%	42.60	22 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007616	Biological process	long-term memory
GO_0000079	Biological process	regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0008344	Biological process	adult locomotory behavior
GO_0045737	Biological process	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0051301	Biological process	cell division
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_1900087	Biological process	positive regulation of G1/S transition of mitotic cell cycle
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0071481	Biological process	cellular response to X-ray
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0000082	Biological process	G1/S transition of mitotic cell cycle
GO_0005730	Cellular component	nucleolus
GO_0005813	Cellular component	centrosome
GO_0005654	Cellular component	nucleoplasm
GO_0097129	Cellular component	cyclin D2-CDK4 complex
GO_0000307	Cellular component	cyclin-dependent protein kinase holoenzyme complex
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0000785	Cellular component	chromatin
GO_0031965	Cellular component	nuclear membrane
GO_0005634	Cellular component	nucleus
GO_0061575	Molecular function	cyclin-dependent protein serine/threonine kinase activator activity
GO_0019901	Molecular function	protein kinase binding
GO_0016538	Molecular function	cyclin-dependent protein serine/threonine kinase regulator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CCND2
Protein name	G1/S-specific cyclin-D2
Synonyms
Description	FUNCTION: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition . Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase . Hypophosphorylates RB1 in early G(1) phase . Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals . .
Accessions	ENST00000676279.1 [P30279-1] ENST00000676411.1 [P30279-1] A0A6Q8PGZ3 P30279 ENST00000261254.8 [P30279-1] ENST00000675880.1

CCND2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review