HYPK report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HYPK at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HYPK at tissue level.

III. Associated gene sets

GO_0006457Biological processprotein folding
GO_0043066Biological processnegative regulation of apoptotic process
GO_0050821Biological processprotein stabilization
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0044183Molecular functionprotein folding chaperone
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHYPK
Protein nameHuntingtin interacting protein K
Huntingtin-interacting protein K (Huntingtin yeast partner K)
SynonymsHSPC136
C15orf63
DescriptionFUNCTION: Component of several N-terminal acetyltransferase complexes . Inhibits the N-terminal acetylation activity of the N-terminal acetyltransferase NAA10-NAA15 complex (also called the NatA complex) . Has chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT in neuronal cells probably while associated with the NatA complex . May play a role in the NatA complex-mediated N-terminal acetylation of PCNP . .

AccessionsJ3QT56
ENST00000406925.6 [Q9NX55-2]
ENST00000458412.2
ENST00000442995.4 [Q9NX55-2]
Q9NX55