EEF2K report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002931Biological processresponse to ischemia
GO_0032869Biological processcellular response to insulin stimulus
GO_0071454Biological processcellular response to anoxia
GO_0061003Biological processpositive regulation of dendritic spine morphogenesis
GO_1990416Biological processcellular response to brain-derived neurotrophic factor stimulus
GO_0140245Biological processregulation of translation at postsynapse
GO_0045807Biological processpositive regulation of endocytosis
GO_0071277Biological processcellular response to calcium ion
GO_0006414Biological processtranslational elongation
GO_0071320Biological processcellular response to cAMP
GO_0043066Biological processnegative regulation of apoptotic process
GO_1990637Biological processresponse to prolactin
GO_0031952Biological processregulation of protein autophosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0051965Biological processpositive regulation of synapse assembly
GO_0031037Biological processmyosin II filament disassembly
GO_0098978Cellular componentglutamatergic synapse
GO_0043197Cellular componentdendritic spine
GO_0005829Cellular componentcytosol
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0004686Molecular functionelongation factor-2 kinase activity
GO_0008135Molecular functiontranslation factor activity, RNA binding
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0005516Molecular functioncalmodulin binding
GO_0005509Molecular functioncalcium ion binding

IV. Literature review

[source]
Gene nameEEF2K
Protein nameEukaryotic elongation factor 2 kinase
Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase)
Alternative protein EEF2K
Synonyms
DescriptionFUNCTION: Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. .

AccessionsO00418
ENST00000568269.5
H3BRH4
ENST00000263026.10
L8E8G5