ASIC2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
glutamatergic neuron	12 studies	57% ± 30%	Explore
GABAergic neuron	10 studies	49% ± 26%	Explore
oligodendrocyte precursor cell	10 studies	42% ± 18%	Explore
interneuron	6 studies	48% ± 27%	Explore
neuron	4 studies	22% ± 3%	Explore
endothelial cell	3 studies	44% ± 20%	Explore
GABAergic interneuron	3 studies	54% ± 17%	Explore
granule cell	3 studies	40% ± 21%	Explore
microglial cell	3 studies	39% ± 23%	Explore
amacrine cell	3 studies	47% ± 20%	Explore
GABAergic amacrine cell	3 studies	76% ± 6%	Explore
glycinergic amacrine cell	3 studies	46% ± 11%	Explore
retinal cone cell	3 studies	47% ± 17%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	12 studies	43% ± 25%	Explore
eye	3 studies	18% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	98%	982.47	2578 / 2642	53%	2.23	377 / 705
uterus	44%	381.78	75 / 170	12%	0.76	54 / 459
kidney	35%	51.70	31 / 89	19%	0.47	168 / 901
adrenal gland	17%	22.15	44 / 258	35%	3.04	80 / 230
prostate	4%	9.00	11 / 245	16%	0.64	78 / 502
ovary	1%	0.60	1 / 180	17%	0.54	75 / 430
breast	1%	0.71	3 / 459	13%	0.61	146 / 1118
intestine	2%	2.43	20 / 966	10%	0.21	53 / 527
stomach	0%	0	0 / 359	9%	0.20	27 / 286
blood vessel	5%	6.45	71 / 1335	0%	0	0 / 0
skin	1%	1.58	22 / 1809	3%	0.28	16 / 472
bladder	0%	0	0 / 21	3%	0.14	14 / 504
eye	0%	0	0 / 0	3%	0.10	2 / 80
lung	0%	0.20	1 / 578	2%	0.12	26 / 1155
liver	1%	1.61	3 / 226	1%	0.01	3 / 406
esophagus	0%	0.07	1 / 1445	2%	0.07	3 / 183
pancreas	0%	0	0 / 328	1%	0.04	2 / 178
thymus	0%	0	0 / 653	1%	0.05	5 / 605
adipose	1%	0.75	8 / 1204	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007605	Biological process	sensory perception of sound
GO_0071466	Biological process	cellular response to xenobiotic stimulus
GO_0042391	Biological process	regulation of membrane potential
GO_0007602	Biological process	phototransduction
GO_0019229	Biological process	regulation of vasoconstriction
GO_0098662	Biological process	inorganic cation transmembrane transport
GO_0071468	Biological process	cellular response to acidic pH
GO_0051649	Biological process	establishment of localization in cell
GO_0050915	Biological process	sensory perception of sour taste
GO_0034765	Biological process	regulation of monoatomic ion transmembrane transport
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0007268	Biological process	chemical synaptic transmission
GO_0007422	Biological process	peripheral nervous system development
GO_0003026	Biological process	regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback
GO_0007417	Biological process	central nervous system development
GO_0007416	Biological process	synapse assembly
GO_0050974	Biological process	detection of mechanical stimulus involved in sensory perception
GO_0035418	Biological process	protein localization to synapse
GO_0051965	Biological process	positive regulation of synapse assembly
GO_0035725	Biological process	sodium ion transmembrane transport
GO_0005886	Cellular component	plasma membrane
GO_0043197	Cellular component	dendritic spine
GO_0043025	Cellular component	neuronal cell body
GO_0005248	Molecular function	voltage-gated sodium channel activity
GO_0015280	Molecular function	ligand-gated sodium channel activity
GO_0022839	Molecular function	monoatomic ion-gated channel activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ASIC2
Protein name	Acid-sensing ion channel 2 (ASIC2) (Amiloride-sensitive brain sodium channel) (Amiloride-sensitive cation channel 1, neuronal) (Amiloride-sensitive cation channel neuronal 1) (Brain sodium channel 1) (BNC1) (BNaC1) (Mammalian degenerin homolog) (MDEG)
Synonyms	ACCN1 MDEG BNAC1 ACCN
Description	FUNCTION: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
Accessions	Q16515 ENST00000225823.7 [Q16515-2] ENST00000359872.6 [Q16515-1]

ASIC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review