Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 4840.57 | 576 / 578 | 87% | 12.66 | 1006 / 1155 |
| breast | 78% | 1140.08 | 358 / 459 | 91% | 12.10 | 1021 / 1118 |
| intestine | 99% | 5129.87 | 957 / 966 | 65% | 6.11 | 341 / 527 |
| bladder | 100% | 9317.95 | 21 / 21 | 57% | 6.64 | 286 / 504 |
| esophagus | 76% | 1427.97 | 1105 / 1445 | 64% | 5.09 | 118 / 183 |
| prostate | 81% | 1534.08 | 199 / 245 | 55% | 3.31 | 274 / 502 |
| stomach | 57% | 852.49 | 206 / 359 | 73% | 7.88 | 208 / 286 |
| kidney | 31% | 485.57 | 28 / 89 | 82% | 12.58 | 741 / 901 |
| brain | 23% | 284.63 | 606 / 2642 | 90% | 13.08 | 635 / 705 |
| uterus | 46% | 466.45 | 78 / 170 | 63% | 5.57 | 287 / 459 |
| adrenal gland | 81% | 1159.04 | 208 / 258 | 26% | 1.76 | 59 / 230 |
| skin | 31% | 319.20 | 559 / 1809 | 75% | 12.31 | 355 / 472 |
| thymus | 35% | 544.41 | 231 / 653 | 67% | 10.03 | 404 / 605 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 96.09 | 29 / 29 |
| peripheral blood | 100% | 13608.41 | 929 / 929 | 0% | 0 | 0 / 0 |
| spleen | 100% | 11980.48 | 241 / 241 | 0% | 0 | 0 / 0 |
| adipose | 96% | 2446.09 | 1159 / 1204 | 0% | 0 | 0 / 0 |
| pancreas | 10% | 108.05 | 32 / 328 | 81% | 10.36 | 145 / 178 |
| blood vessel | 88% | 2942.35 | 1172 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 87% | 13.85 | 39 / 45 |
| ovary | 15% | 155.28 | 27 / 180 | 59% | 4.62 | 253 / 430 |
| liver | 25% | 258.90 | 57 / 226 | 39% | 2.97 | 158 / 406 |
| eye | 0% | 0 | 0 / 0 | 23% | 1.82 | 18 / 80 |
| heart | 21% | 232.43 | 182 / 861 | 0% | 0 | 0 / 0 |
| muscle | 2% | 13.57 | 13 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042327 | Biological process | positive regulation of phosphorylation |
| GO_0043029 | Biological process | T cell homeostasis |
| GO_0042102 | Biological process | positive regulation of T cell proliferation |
| GO_0033630 | Biological process | positive regulation of cell adhesion mediated by integrin |
| GO_0030011 | Biological process | maintenance of cell polarity |
| GO_0002262 | Biological process | myeloid cell homeostasis |
| GO_0030838 | Biological process | positive regulation of actin filament polymerization |
| GO_0048821 | Biological process | erythrocyte development |
| GO_0070358 | Biological process | actin polymerization-dependent cell motility |
| GO_0032715 | Biological process | negative regulation of interleukin-6 production |
| GO_0035509 | Biological process | negative regulation of myosin-light-chain-phosphatase activity |
| GO_0050853 | Biological process | B cell receptor signaling pathway |
| GO_0030593 | Biological process | neutrophil chemotaxis |
| GO_0030031 | Biological process | cell projection assembly |
| GO_0045588 | Biological process | positive regulation of gamma-delta T cell differentiation |
| GO_0006935 | Biological process | chemotaxis |
| GO_0001782 | Biological process | B cell homeostasis |
| GO_0043318 | Biological process | negative regulation of cytotoxic T cell degranulation |
| GO_0045579 | Biological process | positive regulation of B cell differentiation |
| GO_0065003 | Biological process | protein-containing complex assembly |
| GO_0048812 | Biological process | neuron projection morphogenesis |
| GO_0034101 | Biological process | erythrocyte homeostasis |
| GO_1902624 | Biological process | positive regulation of neutrophil migration |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0043378 | Biological process | positive regulation of CD8-positive, alpha-beta T cell differentiation |
| GO_0030890 | Biological process | positive regulation of B cell proliferation |
| GO_0045621 | Biological process | positive regulation of lymphocyte differentiation |
| GO_0045648 | Biological process | positive regulation of erythrocyte differentiation |
| GO_1904515 | Biological process | positive regulation of TORC2 signaling |
| GO_0002687 | Biological process | positive regulation of leukocyte migration |
| GO_0090023 | Biological process | positive regulation of neutrophil chemotaxis |
| GO_0000902 | Biological process | cell morphogenesis |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0032700 | Biological process | negative regulation of interleukin-17 production |
| GO_0043372 | Biological process | positive regulation of CD4-positive, alpha-beta T cell differentiation |
| GO_0060100 | Biological process | positive regulation of phagocytosis, engulfment |
| GO_0030866 | Biological process | cortical actin cytoskeleton organization |
| GO_0016477 | Biological process | cell migration |
| GO_0030667 | Cellular component | secretory granule membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005829 | Cellular component | cytosol |
| GO_0101003 | Cellular component | ficolin-1-rich granule membrane |
| GO_0031209 | Cellular component | SCAR complex |
| GO_1904841 | Molecular function | TORC2 complex binding |
| GO_0044877 | Molecular function | protein-containing complex binding |
| GO_0005096 | Molecular function | GTPase activator activity |
| GO_0030295 | Molecular function | protein kinase activator activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NCKAP1L |
| Protein name | NCK associated protein 1 like NCKAP1L protein Nck-associated protein 1-like (Hematopoietic protein 1) (Membrane-associated protein HEM-1) |
| Synonyms | HEM1 |
| Description | FUNCTION: Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages . Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (By similarity). Within the WAVE2 complex, enables the cortical actin network to restrain excessive degranulation and granule release by T-cells . Required for efficient T-lymphocyte and neutrophil migration . Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin . Also involved in mechanisms WAVE-independent to regulate myosin and actin polymerization during neutrophil chemotaxis . In T-cells, required for proper mechanistic target of rapamycin complex 2 (mTORC2)-dependent AKT phosphorylation, cell proliferation and cytokine secretion, including that of IL2 and TNF . . |
| Accessions | ENST00000293373.11 [P55160-1] Q6P1M2 P55160 ENST00000548221.5 ENST00000545638.2 [P55160-2] Q5XG97 F8W050 Q9BV52 |
