Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 5 studies | 26% ± 9% | |
| astrocyte | 5 studies | 28% ± 10% | |
| oligodendrocyte precursor cell | 4 studies | 20% ± 5% | |
| hematopoietic precursor cell | 3 studies | 19% ± 2% | |
| basal cell | 3 studies | 23% ± 10% | |
| transit amplifying cell | 3 studies | 45% ± 24% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 19% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 731.59 | 1445 / 1445 | 100% | 9.47 | 183 / 183 |
| lung | 99% | 642.56 | 574 / 578 | 98% | 6.91 | 1132 / 1155 |
| breast | 99% | 510.92 | 456 / 459 | 98% | 9.46 | 1094 / 1118 |
| uterus | 100% | 714.01 | 170 / 170 | 97% | 10.31 | 445 / 459 |
| intestine | 100% | 594.47 | 965 / 966 | 96% | 6.62 | 507 / 527 |
| ovary | 99% | 437.59 | 178 / 180 | 97% | 7.16 | 418 / 430 |
| bladder | 100% | 507.48 | 21 / 21 | 89% | 5.66 | 448 / 504 |
| stomach | 91% | 316.86 | 328 / 359 | 94% | 6.80 | 269 / 286 |
| prostate | 100% | 525.57 | 244 / 245 | 83% | 3.83 | 419 / 502 |
| skin | 100% | 1621.68 | 1806 / 1809 | 82% | 4.45 | 389 / 472 |
| thymus | 99% | 377.40 | 649 / 653 | 81% | 3.64 | 491 / 605 |
| pancreas | 84% | 208.84 | 276 / 328 | 89% | 4.07 | 159 / 178 |
| brain | 64% | 169.71 | 1692 / 2642 | 95% | 7.27 | 672 / 705 |
| blood vessel | 100% | 769.65 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 7.01 | 29 / 29 |
| spleen | 100% | 476.68 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 2.34 | 1 / 1 |
| adipose | 98% | 421.53 | 1178 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 12.42 | 44 / 45 |
| muscle | 98% | 538.44 | 785 / 803 | 0% | 0 | 0 / 0 |
| kidney | 46% | 117.70 | 41 / 89 | 51% | 1.81 | 461 / 901 |
| adrenal gland | 61% | 115.45 | 157 / 258 | 34% | 1.18 | 78 / 230 |
| heart | 78% | 209.48 | 670 / 861 | 0% | 0 | 0 / 0 |
| liver | 23% | 47.28 | 53 / 226 | 32% | 1.35 | 128 / 406 |
| peripheral blood | 52% | 623.28 | 484 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 13% | 0.31 | 10 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0016567 | Biological process | protein ubiquitination |
| GO_0006281 | Biological process | DNA repair |
| GO_0046826 | Biological process | negative regulation of protein export from nucleus |
| GO_0045786 | Biological process | negative regulation of cell cycle |
| GO_0006282 | Biological process | regulation of DNA repair |
| GO_0006974 | Biological process | DNA damage response |
| GO_0042325 | Biological process | regulation of phosphorylation |
| GO_0110025 | Biological process | DNA strand resection involved in replication fork processing |
| GO_0045732 | Biological process | positive regulation of protein catabolic process |
| GO_0031441 | Biological process | negative regulation of mRNA 3'-end processing |
| GO_0044818 | Biological process | mitotic G2/M transition checkpoint |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0035825 | Biological process | homologous recombination |
| GO_0001894 | Biological process | tissue homeostasis |
| GO_2000001 | Biological process | regulation of DNA damage checkpoint |
| GO_0071479 | Biological process | cellular response to ionizing radiation |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0051726 | Biological process | regulation of cell cycle |
| GO_0085020 | Biological process | protein K6-linked ubiquitination |
| GO_0000151 | Cellular component | ubiquitin ligase complex |
| GO_0036464 | Cellular component | cytoplasmic ribonucleoprotein granule |
| GO_0016607 | Cellular component | nuclear speck |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0070531 | Cellular component | BRCA1-A complex |
| GO_0000152 | Cellular component | nuclear ubiquitin ligase complex |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0070533 | Cellular component | BRCA1-C complex |
| GO_0070532 | Cellular component | BRCA1-B complex |
| GO_0031436 | Cellular component | BRCA1-BARD1 complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0019900 | Molecular function | kinase binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0003723 | Molecular function | RNA binding |
| GO_0046982 | Molecular function | protein heterodimerization activity |
| GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | BARD1 |
| Protein name | BRCA1 associated RING domain 1 isoform eta BRCA1 associated RING domain 1 BRCA1 associated RING domain 1 isoform epsilon BRCA1 associated RING domain 1 isoform pi BRCA1 associated RING domain 1 isoform phi BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1) |
| Synonyms | |
| Description | FUNCTION: E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. . |
| Accessions | A0A494C142 ENST00000619009.5 F6MDI1 Q99728 F8WCG2 A0AVN2 C9J6M1 F6MDI0 F6MDI2 ENST00000620057.4 [Q99728-4] A0A087WZ19 ENST00000613192.2 A0A087X0C6 ENST00000613706.5 ENST00000260947.9 [Q99728-1] A0A087X2H0 ENST00000650978.1 ENST00000613374.5 ENST00000617164.5 [Q99728-2] ENST00000455743.5 F6MDI3 F6MDI4 ENST00000421162.2 ENST00000432456.5 C9IYG1 |
