RGN report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RGN at tissue level.

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_0019853Biological processL-ascorbic acid biosynthetic process
GO_0032781Biological processpositive regulation of ATP-dependent activity
GO_1901318Biological processnegative regulation of flagellated sperm motility
GO_0045723Biological processpositive regulation of fatty acid biosynthetic process
GO_0001822Biological processkidney development
GO_0045019Biological processnegative regulation of nitric oxide biosynthetic process
GO_0006874Biological processintracellular calcium ion homeostasis
GO_1903011Biological processnegative regulation of bone development
GO_1903052Biological processpositive regulation of proteolysis involved in protein catabolic process
GO_0010867Biological processpositive regulation of triglyceride biosynthetic process
GO_0050680Biological processnegative regulation of epithelial cell proliferation
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0097421Biological processliver regeneration
GO_0043066Biological processnegative regulation of apoptotic process
GO_0050848Biological processregulation of calcium-mediated signaling
GO_0010907Biological processpositive regulation of glucose metabolic process
GO_1902679Biological processnegative regulation of RNA biosynthetic process
GO_1903625Biological processnegative regulation of DNA catabolic process
GO_2000279Biological processnegative regulation of DNA biosynthetic process
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004341Molecular functiongluconolactonase activity
GO_0008270Molecular functionzinc ion binding
GO_0005509Molecular functioncalcium ion binding
GO_0030234Molecular functionenzyme regulator activity

IV. Literature review

[source]
Gene nameRGN
Protein nameRegucalcin (RC) (Gluconolactonase) (GNL) (EC 3.1.1.17) (Senescence marker protein 30) (SMP-30)
SynonymsSMP30
DescriptionFUNCTION: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). .

AccessionsENST00000457380.5 [Q15493-2]
ENST00000397180.6 [Q15493-1]
ENST00000336169.3 [Q15493-1]
ENST00000352078.8 [Q15493-1]
Q15493