MAD2L1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042177Biological processnegative regulation of protein catabolic process
GO_0000070Biological processmitotic sister chromatid segregation
GO_0000132Biological processestablishment of mitotic spindle orientation
GO_0051301Biological processcell division
GO_0043066Biological processnegative regulation of apoptotic process
GO_0090267Biological processpositive regulation of mitotic cell cycle spindle assembly checkpoint
GO_1904667Biological processnegative regulation of ubiquitin protein ligase activity
GO_0045930Biological processnegative regulation of mitotic cell cycle
GO_0007094Biological processmitotic spindle assembly checkpoint signaling
GO_0051660Biological processestablishment of centrosome localization
GO_0000922Cellular componentspindle pole
GO_0072686Cellular componentmitotic spindle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0000776Cellular componentkinetochore
GO_0005654Cellular componentnucleoplasm
GO_0033597Cellular componentmitotic checkpoint complex
GO_0044615Cellular componentnuclear pore nuclear basket
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1990728Cellular componentmitotic spindle assembly checkpoint MAD1-MAD2 complex
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAD2L1
Protein nameMitotic arrest deficient 2 like 1
Mitotic spindle assembly checkpoint protein MAD2A (HsMAD2) (Mitotic arrest deficient 2-like protein 1) (MAD2-like protein 1)
SynonymsMAD2
DescriptionFUNCTION: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate . In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, the complex recruits open conformation molecules of MAD2L1 (O-MAD2) and then promotes the conversion of O-MAD2 to C-MAD2 . Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate . .

AccessionsD6RJE3
ENST00000333047.9 [Q13257-2]
ENST00000296509.11 [Q13257-1]
Q13257
ENST00000504707.1