| Name | mitotic spindle assembly checkpoint MAD1-MAD2 complex |
| ID | GO_1990728 |
| collection_id | Cellular component |
| Exact synonym | MAD1-MAD2 complex |
| Description | A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). The MAD1 dimer recruits the open form of MAD2 (O-MAD2) turning it into the closed form (C-MAD2) upon binding. C-MAD2 inhibits CDC20, a member of the APC/C, upon release from the MAD1-MAD2 complex. |
| Comment | An example of this is MAD1 in human (Q9Y6D9) in PMID:12006501 (inferred from physical interaction). |
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| Genes |