MAD1L1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051315Biological processattachment of mitotic spindle microtubules to kinetochore
GO_0051301Biological processcell division
GO_0042130Biological processnegative regulation of T cell proliferation
GO_0048538Biological processthymus development
GO_0090267Biological processpositive regulation of mitotic cell cycle spindle assembly checkpoint
GO_0090235Biological processregulation of metaphase plate congression
GO_0007094Biological processmitotic spindle assembly checkpoint signaling
GO_0097431Cellular componentmitotic spindle pole
GO_0072686Cellular componentmitotic spindle
GO_1990706Cellular componentMAD1 complex
GO_0005813Cellular componentcentrosome
GO_0000776Cellular componentkinetochore
GO_0005635Cellular componentnuclear envelope
GO_0044615Cellular componentnuclear pore nuclear basket
GO_0005829Cellular componentcytosol
GO_0005819Cellular componentspindle
GO_1990728Cellular componentmitotic spindle assembly checkpoint MAD1-MAD2 complex
GO_0042802Molecular functionidentical protein binding
GO_0043515Molecular functionkinetochore binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAD1L1
Protein nameMitotic arrest deficient 1 like 1
Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181)
MAD1 mitotic arrest deficient-like 1 (Yeast)
Synonymstcag7.525
MAD1
TXBP181
DescriptionFUNCTION: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate . Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling . .; FUNCTION: [Isoform 3]: Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas. .

AccessionsA4D218
ENST00000402746.5 [Q9Y6D9-3]
ENST00000437877.1
ENST00000399654.6 [Q9Y6D9-1]
ENST00000429779.1
ENST00000444373.6
C9JKI7
Q9Y6D9
ENST00000265854.12 [Q9Y6D9-1]
ENST00000406869.5 [Q9Y6D9-1]
C9JIR0
C9JX80
ENST00000455998.5
C9JJ38
C9J9H5
ENST00000421113.5