PIAS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0065004Biological processprotein-DNA complex assembly
GO_0016925Biological processprotein sumoylation
GO_1904377Biological processpositive regulation of protein localization to cell periphery
GO_0007283Biological processspermatogenesis
GO_0045444Biological processfat cell differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0006974Biological processDNA damage response
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0051152Biological processpositive regulation of smooth muscle cell differentiation
GO_0008542Biological processvisual learning
GO_0033235Biological processpositive regulation of protein sumoylation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0007259Biological processcell surface receptor signaling pathway via JAK-STAT
GO_0042127Biological processregulation of cell population proliferation
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0005856Cellular componentcytoskeleton
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0034399Cellular componentnuclear periphery
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0019789Molecular functionSUMO transferase activity
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0019904Molecular functionprotein domain specific binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0061665Molecular functionSUMO ligase activity
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePIAS1
Protein nameCell proliferation-inducing protein 23 (Protein inhibitor of activated STAT, 1, isoform CRA_b)
E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein)
Protein inhibitor of activated STAT 1
Protein inhibitor of activated STAT1
SynonymshCG_23811
DDXBP1
DescriptionFUNCTION: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). Mediates the nuclear mobility and localization of MSX1 to the nuclear periphery, whereby MSX1 is brought into the proximity of target myoblast differentiation factor genes (By similarity). Also required for the binding of MSX1 to the core enhancer region in target gene promoter regions, independent of its sumolyation activity (By similarity). Capable of binding to the core enhancer region TAAT box in the MYOD1 gene promoter (By similarity). .; FUNCTION: (Microbial infection) Restricts Epstein-Barr virus (EBV) lytic replication by acting as an inhibitor for transcription factors involved in lytic gene expression . The virus can use apoptotic caspases to antagonize PIAS1-mediated restriction and express its lytic genes . .

AccessionsH3BUL7
Q1XBU8
ENST00000249636.11 [O75925-1]
A4ZVS7
ENST00000545237.1 [O75925-2]
ENST00000564915.5
ENST00000563996.1
A4ZVS8
O75925
H3BS65
ENST00000562190.1
H3BSI8