TBX3 | OmnibusX

Name	Number of supported studies	Average coverage
pericyte	17 studies	30% ± 13%	Explore
endothelial cell	11 studies	30% ± 12%	Explore
smooth muscle cell	11 studies	29% ± 10%	Explore
fibroblast	10 studies	23% ± 7%	Explore
myofibroblast cell	8 studies	37% ± 13%	Explore
capillary endothelial cell	7 studies	36% ± 10%	Explore
connective tissue cell	5 studies	28% ± 5%	Explore
glomerular endothelial cell	4 studies	42% ± 7%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	42% ± 3%	Explore
abnormal cell	3 studies	34% ± 13%	Explore
neural crest cell	3 studies	44% ± 19%	Explore
glial cell	3 studies	32% ± 24%	Explore
neuron	3 studies	56% ± 23%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TBX3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	19427.25	245 / 245	100%	166.13	502 / 502
breast	100%	8707.93	458 / 459	85%	73.25	955 / 1118
thymus	100%	12529.18	653 / 653	85%	105.63	515 / 605
bladder	100%	12325.57	21 / 21	69%	70.54	349 / 504
adrenal gland	100%	38000.26	258 / 258	65%	124.24	150 / 230
intestine	93%	2064.15	899 / 966	55%	17.09	291 / 527
skin	99%	3957.82	1796 / 1809	43%	18.97	203 / 472
liver	99%	3531.50	223 / 226	43%	22.69	175 / 406
uterus	100%	6958.89	170 / 170	38%	16.50	173 / 459
lung	100%	7721.04	577 / 578	23%	5.80	270 / 1155
ovary	100%	9884.01	180 / 180	11%	2.61	49 / 430
ureter	0%	0	0 / 0	100%	77.42	1 / 1
adipose	99%	2953.69	1190 / 1204	0%	0	0 / 0
kidney	90%	1864.58	80 / 89	6%	2.05	56 / 901
esophagus	48%	687.34	694 / 1445	43%	13.46	79 / 183
stomach	38%	536.48	136 / 359	46%	12.55	131 / 286
spleen	83%	1485.55	199 / 241	0%	0	0 / 0
muscle	80%	1194.00	641 / 803	0%	0	0 / 0
heart	72%	1221.65	624 / 861	0%	0	0 / 0
pancreas	5%	57.21	17 / 328	29%	9.92	51 / 178
blood vessel	20%	259.04	263 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	16%	3.05	7 / 45
brain	8%	115.31	210 / 2642	2%	0.91	15 / 705
lymph node	0%	0	0 / 0	3%	0.46	1 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0046884	Biological process	follicle-stimulating hormone secretion
GO_0030879	Biological process	mammary gland development
GO_0003151	Biological process	outflow tract morphogenesis
GO_0001708	Biological process	cell fate specification
GO_0030540	Biological process	female genitalia development
GO_0001701	Biological process	in utero embryonic development
GO_0003167	Biological process	atrioventricular bundle cell differentiation
GO_0003272	Biological process	endocardial cushion formation
GO_0035136	Biological process	forelimb morphogenesis
GO_0060444	Biological process	branching involved in mammary gland duct morphogenesis
GO_0001947	Biological process	heart looping
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0009887	Biological process	animal organ morphogenesis
GO_0045662	Biological process	negative regulation of myoblast differentiation
GO_0061635	Biological process	regulation of protein complex stability
GO_0042733	Biological process	embryonic digit morphogenesis
GO_0008595	Biological process	anterior/posterior axis specification, embryo
GO_2000648	Biological process	positive regulation of stem cell proliferation
GO_1905222	Biological process	atrioventricular canal morphogenesis
GO_1905072	Biological process	cardiac jelly development
GO_0072089	Biological process	stem cell proliferation
GO_0072105	Biological process	ureteric peristalsis
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0010159	Biological process	specification of animal organ position
GO_0060923	Biological process	cardiac muscle cell fate commitment
GO_0060931	Biological process	sinoatrial node cell development
GO_0035115	Biological process	embryonic forelimb morphogenesis
GO_0035116	Biological process	embryonic hindlimb morphogenesis
GO_0060317	Biological process	cardiac epithelial to mesenchymal transition
GO_0048332	Biological process	mesoderm morphogenesis
GO_0006351	Biological process	DNA-templated transcription
GO_0030857	Biological process	negative regulation of epithelial cell differentiation
GO_0060021	Biological process	roof of mouth development
GO_0061017	Biological process	hepatoblast differentiation
GO_0060596	Biological process	mammary placode formation
GO_0048752	Biological process	semicircular canal morphogenesis
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0030539	Biological process	male genitalia development
GO_0032275	Biological process	luteinizing hormone secretion
GO_0019827	Biological process	stem cell population maintenance
GO_0051145	Biological process	smooth muscle cell differentiation
GO_2000137	Biological process	negative regulation of cell proliferation involved in heart morphogenesis
GO_0060412	Biological process	ventricular septum morphogenesis
GO_0001568	Biological process	blood vessel development
GO_2000737	Biological process	negative regulation of stem cell differentiation
GO_0036302	Biological process	atrioventricular canal development
GO_0001501	Biological process	skeletal system development
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0090398	Biological process	cellular senescence
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0031647	Biological process	regulation of protein stability
GO_0045787	Biological process	positive regulation of cell cycle
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0021761	Biological process	limbic system development
GO_0005929	Cellular component	cilium
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565	Molecular function	sequence-specific DNA binding
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0061629	Molecular function	RNA polymerase II-specific DNA-binding transcription factor binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TBX3
Protein name	T-box transcription factor TBX3 (T-box protein 3)
Synonyms
Description	FUNCTION: Transcriptional repressor involved in developmental processes . Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes . Probably plays a role in limb pattern formation . Required for mammary placode induction, and maintenance of the mammary buds during development (By similarity). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (By similarity). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence . .
Accessions	ENST00000257566.7 [O15119-1] O15119 ENST00000349155.7 [O15119-2]

TBX3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review