MCL1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	45 studies	53% ± 23%	Explore
endothelial cell	42 studies	45% ± 18%	Explore
natural killer cell	39 studies	42% ± 17%	Explore
fibroblast	38 studies	44% ± 20%	Explore
T cell	35 studies	43% ± 17%	Explore
B cell	34 studies	37% ± 14%	Explore
CD8-positive, alpha-beta T cell	33 studies	42% ± 15%	Explore
conventional dendritic cell	30 studies	64% ± 19%	Explore
CD4-positive, alpha-beta T cell	30 studies	42% ± 15%	Explore
dendritic cell	29 studies	57% ± 23%	Explore
pericyte	29 studies	43% ± 19%	Explore
classical monocyte	29 studies	71% ± 17%	Explore
monocyte	26 studies	58% ± 22%	Explore
non-classical monocyte	25 studies	61% ± 18%	Explore
smooth muscle cell	24 studies	38% ± 14%	Explore
regulatory T cell	24 studies	44% ± 14%	Explore
mast cell	22 studies	53% ± 20%	Explore
basal cell	21 studies	45% ± 14%	Explore
epithelial cell	21 studies	41% ± 18%	Explore
plasma cell	20 studies	50% ± 19%	Explore
endothelial cell of lymphatic vessel	20 studies	42% ± 17%	Explore
mature NK T cell	19 studies	42% ± 15%	Explore
plasmacytoid dendritic cell	19 studies	54% ± 17%	Explore
gamma-delta T cell	17 studies	46% ± 20%	Explore
connective tissue cell	17 studies	41% ± 13%	Explore
memory B cell	16 studies	37% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	36% ± 12%	Explore
neutrophil	15 studies	67% ± 15%	Explore
naive B cell	15 studies	27% ± 8%	Explore
myeloid cell	15 studies	55% ± 25%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	42% ± 20%	Explore
mucosal invariant T cell	14 studies	40% ± 17%	Explore
capillary endothelial cell	14 studies	35% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	35% ± 13%	Explore
myofibroblast cell	13 studies	40% ± 19%	Explore
endothelial cell of vascular tree	13 studies	45% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	45% ± 16%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	42% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	47% ± 17%	Explore
ciliated cell	12 studies	36% ± 16%	Explore
secretory cell	12 studies	39% ± 12%	Explore
endothelial cell of artery	12 studies	41% ± 15%	Explore
vein endothelial cell	12 studies	39% ± 14%	Explore
type I pneumocyte	11 studies	39% ± 19%	Explore
type II pneumocyte	11 studies	38% ± 18%	Explore
goblet cell	11 studies	38% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	45% ± 17%	Explore
plasmablast	10 studies	48% ± 21%	Explore
leukocyte	10 studies	49% ± 21%	Explore
abnormal cell	10 studies	35% ± 16%	Explore
club cell	9 studies	34% ± 18%	Explore
alveolar macrophage	8 studies	58% ± 15%	Explore
mononuclear phagocyte	8 studies	60% ± 24%	Explore
IgA plasma cell	8 studies	38% ± 13%	Explore
IgG plasma cell	8 studies	35% ± 9%	Explore
respiratory goblet cell	7 studies	30% ± 15%	Explore
progenitor cell	7 studies	34% ± 16%	Explore
innate lymphoid cell	7 studies	52% ± 13%	Explore
mesothelial cell	7 studies	36% ± 22%	Explore
T follicular helper cell	7 studies	48% ± 14%	Explore
hematopoietic precursor cell	6 studies	47% ± 20%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	40% ± 17%	Explore
enterocyte	6 studies	27% ± 6%	Explore
microglial cell	6 studies	30% ± 24%	Explore
intermediate monocyte	6 studies	67% ± 31%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	46% ± 16%	Explore
CD4-positive helper T cell	5 studies	50% ± 19%	Explore
exhausted T cell	5 studies	47% ± 13%	Explore
platelet	5 studies	26% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	46% ± 20%	Explore
kidney loop of Henle epithelial cell	5 studies	29% ± 13%	Explore
hematopoietic stem cell	5 studies	43% ± 21%	Explore
precursor B cell	5 studies	31% ± 6%	Explore
brush cell	5 studies	25% ± 9%	Explore
group 3 innate lymphoid cell	5 studies	65% ± 9%	Explore
astrocyte	5 studies	25% ± 6%	Explore
granulocyte	5 studies	61% ± 17%	Explore
ionocyte	4 studies	34% ± 11%	Explore
squamous epithelial cell	4 studies	53% ± 16%	Explore
glomerular endothelial cell	4 studies	35% ± 16%	Explore
transit amplifying cell	4 studies	27% ± 14%	Explore
lymphocyte	4 studies	50% ± 16%	Explore
T-helper 17 cell	4 studies	67% ± 15%	Explore
immature B cell	4 studies	34% ± 7%	Explore
retinal pigment epithelial cell	4 studies	42% ± 18%	Explore
adventitial cell	4 studies	48% ± 19%	Explore
inflammatory macrophage	4 studies	45% ± 8%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	58% ± 10%	Explore
enteroendocrine cell	4 studies	34% ± 14%	Explore
keratinocyte	4 studies	40% ± 25%	Explore
T-helper 1 cell	4 studies	54% ± 20%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	32% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	27% ± 8%	Explore
duct epithelial cell	3 studies	20% ± 0%	Explore
pancreatic A cell	3 studies	29% ± 9%	Explore
monocyte-derived dendritic cell	3 studies	83% ± 12%	Explore
erythrocyte	3 studies	32% ± 8%	Explore
epithelial cell of proximal tubule	3 studies	27% ± 6%	Explore
intestinal crypt stem cell	3 studies	24% ± 9%	Explore
renal principal cell	3 studies	37% ± 24%	Explore
extravillous trophoblast	3 studies	26% ± 7%	Explore
placental villous trophoblast	3 studies	24% ± 9%	Explore
common myeloid progenitor	3 studies	41% ± 14%	Explore
pro-B cell	3 studies	26% ± 6%	Explore
neuroendocrine cell	3 studies	29% ± 10%	Explore
adipocyte	3 studies	19% ± 3%	Explore
tissue-resident macrophage	3 studies	67% ± 23%	Explore
intraepithelial lymphocyte	3 studies	34% ± 13%	Explore
Mueller cell	3 studies	27% ± 7%	Explore
acinar cell	3 studies	50% ± 21%	Explore
germinal center B cell	3 studies	28% ± 4%	Explore
luminal cell of prostate epithelium	3 studies	48% ± 3%	Explore
muscle cell	3 studies	39% ± 17%	Explore
glutamatergic neuron	3 studies	18% ± 1%	Explore
pancreatic ductal cell	3 studies	56% ± 20%	Explore
oligodendrocyte precursor cell	3 studies	23% ± 5%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	53% ± 6%	Explore
glial cell	3 studies	37% ± 11%	Explore
mucus secreting cell	3 studies	24% ± 9%	Explore
progenitor cell of mammary luminal epithelium	3 studies	49% ± 14%	Explore
hepatocyte	3 studies	60% ± 26%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	45% ± 16%	Explore
peripheral blood	19 studies	41% ± 14%	Explore
intestine	11 studies	41% ± 18%	Explore
kidney	8 studies	36% ± 17%	Explore
liver	6 studies	39% ± 15%	Explore
placenta	5 studies	30% ± 11%	Explore
uterus	5 studies	59% ± 9%	Explore
lymph node	5 studies	42% ± 14%	Explore
brain	5 studies	25% ± 14%	Explore
bone marrow	4 studies	43% ± 16%	Explore
eye	4 studies	38% ± 18%	Explore
prostate	4 studies	35% ± 11%	Explore
breast	4 studies	54% ± 3%	Explore
pancreas	3 studies	36% ± 14%	Explore
adipose	3 studies	33% ± 16%	Explore
adrenal gland	3 studies	42% ± 21%	Explore
esophagus	3 studies	49% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	28160.32	1445 / 1445	100%	271.49	183 / 183
lung	100%	48349.04	578 / 578	100%	259.15	1155 / 1155
ovary	100%	20134.77	180 / 180	100%	152.58	430 / 430
breast	100%	29336.43	459 / 459	100%	279.90	1117 / 1118
bladder	100%	22208.29	21 / 21	100%	214.91	503 / 504
uterus	100%	19651.29	170 / 170	100%	248.88	458 / 459
intestine	100%	26731.42	965 / 966	100%	184.01	526 / 527
thymus	100%	22031.09	652 / 653	100%	223.09	603 / 605
liver	100%	20825.07	226 / 226	100%	161.12	404 / 406
stomach	99%	25758.50	356 / 359	100%	182.82	285 / 286
prostate	100%	16418.13	244 / 245	99%	184.77	498 / 502
pancreas	98%	16805.02	323 / 328	100%	275.82	178 / 178
skin	100%	33212.14	1809 / 1809	97%	190.86	459 / 472
kidney	100%	16492.19	89 / 89	97%	202.43	872 / 901
adrenal gland	100%	22510.90	258 / 258	92%	126.14	212 / 230
brain	77%	6917.93	2025 / 2642	100%	164.59	703 / 705
adipose	100%	39872.84	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	307.56	29 / 29
spleen	100%	32959.32	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	233.23	45 / 45
ureter	0%	0	0 / 0	100%	81.41	1 / 1
blood vessel	100%	30794.99	1334 / 1335	0%	0	0 / 0
muscle	100%	17355.99	799 / 803	0%	0	0 / 0
peripheral blood	99%	50920.55	922 / 929	0%	0	0 / 0
heart	98%	15968.56	841 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	73%	59.08	58 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1903378	Biological process	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO_0006919	Biological process	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0001709	Biological process	cell fate determination
GO_0034097	Biological process	response to cytokine
GO_0006974	Biological process	DNA damage response
GO_0008053	Biological process	mitochondrial fusion
GO_2000811	Biological process	negative regulation of anoikis
GO_0019725	Biological process	cellular homeostasis
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0097192	Biological process	extrinsic apoptotic signaling pathway in absence of ligand
GO_0008630	Biological process	intrinsic apoptotic signaling pathway in response to DNA damage
GO_0001836	Biological process	release of cytochrome c from mitochondria
GO_0010507	Biological process	negative regulation of autophagy
GO_2001240	Biological process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0071806	Biological process	protein transmembrane transport
GO_0016020	Cellular component	membrane
GO_0005739	Cellular component	mitochondrion
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0097136	Cellular component	Bcl-2 family protein complex
GO_0005634	Cellular component	nucleus
GO_0051434	Molecular function	BH3 domain binding
GO_0015267	Molecular function	channel activity
GO_0008320	Molecular function	protein transmembrane transporter activity
GO_0046982	Molecular function	protein heterodimerization activity
GO_0051400	Molecular function	BH domain binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	MCL1
Protein name	MCL1 apoptosis regulator, BCL2 family member Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT) Myosin light chain 1 Myeloid cell leukemia ES variant
Synonyms	BCL2L3
Description	FUNCTION: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. .
Accessions	A0A7I2V2W2 A0A087WT64 ENST00000620947.4 ENST00000678610.1 C8YZ26 ENST00000678770.1 [Q07820-1] ENST00000369026.3 [Q07820-1] Q03399 Q07820 ENST00000307940.3 [Q07820-2]

MCL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review