EIF2AK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902033Biological processregulation of hematopoietic stem cell proliferation
GO_0032722Biological processpositive regulation of chemokine production
GO_0008285Biological processnegative regulation of cell population proliferation
GO_1901532Biological processregulation of hematopoietic progenitor cell differentiation
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0045071Biological processnegative regulation of viral genome replication
GO_0032874Biological processpositive regulation of stress-activated MAPK cascade
GO_0033689Biological processnegative regulation of osteoblast proliferation
GO_0006412Biological processtranslation
GO_0009615Biological processresponse to virus
GO_0051607Biological processdefense response to virus
GO_0035455Biological processresponse to interferon-alpha
GO_0036492Biological processeiF2alpha phosphorylation in response to endoplasmic reticulum stress
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0030968Biological processendoplasmic reticulum unfolded protein response
GO_0043066Biological processnegative regulation of apoptotic process
GO_1900225Biological processregulation of NLRP3 inflammasome complex assembly
GO_1902036Biological processregulation of hematopoietic stem cell differentiation
GO_0034198Biological processcellular response to amino acid starvation
GO_0001819Biological processpositive regulation of cytokine production
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0017148Biological processnegative regulation of translation
GO_0140374Biological processantiviral innate immune response
GO_0005840Cellular componentribosome
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0004694Molecular functioneukaryotic translation initiation factor 2alpha kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0016301Molecular functionkinase activity
GO_0003723Molecular functionRNA binding
GO_0019888Molecular functionprotein phosphatase regulator activity
GO_0005515Molecular functionprotein binding
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameEIF2AK2
Protein nameEukaryotic translation initiation factor 2 alpha kinase 2
Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)
eIF2AK2 protein
SynonymsPRKR
PKR
DescriptionFUNCTION: IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection . Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4 . Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1) . Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11 . In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteasomal degradation . Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding pro-inflammatory cytokines and IFNs . Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6 . Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) . Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) . Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes . Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin (By similarity). .

AccessionsQ8IW76
ENST00000395127.6 [P19525-1]
ENST00000680273.1
A0A7P0Z4M0
ENST00000679507.1 [P19525-1]
ENST00000233057.9 [P19525-1]
ENST00000681463.1 [P19525-1]
A0A7P0TBA9
Q05CP4
Q6PK38
ENST00000647926.1 [P19525-1]
A0A7P0TAL9
ENST00000405334.5 [P19525-2]
ENST00000681507.1 [P19525-1]
P19525
ENST00000679979.1
ENST00000681516.1
B7ZKK7