TFAP2B report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TFAP2B at tissue level.

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0050796Biological processregulation of insulin secretion
GO_0072017Biological processdistal tubule development
GO_0048485Biological processsympathetic nervous system development
GO_0035136Biological processforelimb morphogenesis
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0030510Biological processregulation of BMP signaling pathway
GO_0001822Biological processkidney development
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0035137Biological processhindlimb morphogenesis
GO_0072210Biological processmetanephric nephron development
GO_0051402Biological processneuron apoptotic process
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0045595Biological processregulation of cell differentiation
GO_0035909Biological processaorta morphogenesis
GO_0072044Biological processcollecting duct development
GO_0097070Biological processductus arteriosus closure
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0048856Biological processanatomical structure development
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0043588Biological processskin development
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0042127Biological processregulation of cell population proliferation
GO_0006006Biological processglucose metabolic process
GO_0048745Biological processsmooth muscle tissue development
GO_0045444Biological processfat cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0010842Biological processretina layer formation
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTFAP2B
Protein nameTranscription factor AP-2 beta
Transcription factor AP-2-beta (AP2-beta) (Activating enhancer-binding protein 2-beta)
Synonyms
DescriptionFUNCTION: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. .

AccessionsQ92481
ENST00000344788.7
ENST00000393655.4 [Q92481-1]
X6R4Y8