HAX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903214Biological processregulation of protein targeting to mitochondrion
GO_0110053Biological processregulation of actin filament organization
GO_0030833Biological processregulation of actin filament polymerization
GO_0030854Biological processpositive regulation of granulocyte differentiation
GO_1903146Biological processregulation of autophagy of mitochondrion
GO_0007005Biological processmitochondrion organization
GO_0038158Biological processgranulocyte colony-stimulating factor signaling pathway
GO_0043066Biological processnegative regulation of apoptotic process
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0042981Biological processregulation of apoptotic process
GO_0071345Biological processcellular response to cytokine stimulus
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016324Cellular componentapical plasma membrane
GO_0005739Cellular componentmitochondrion
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0030136Cellular componentclathrin-coated vesicle
GO_0005635Cellular componentnuclear envelope
GO_0000932Cellular componentP-body
GO_0015629Cellular componentactin cytoskeleton
GO_0005783Cellular componentendoplasmic reticulum
GO_0005938Cellular componentcell cortex
GO_0005759Cellular componentmitochondrial matrix
GO_0016529Cellular componentsarcoplasmic reticulum
GO_0005741Cellular componentmitochondrial outer membrane
GO_0030027Cellular componentlamellipodium
GO_0031965Cellular componentnuclear membrane
GO_0005667Cellular componenttranscription regulator complex
GO_0019966Molecular functioninterleukin-1 binding
GO_0035591Molecular functionsignaling adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHAX1
Protein nameHCLS1 associated protein X-1 isoform 1
HCLS1 associated protein X-1
HCLS1 associated protein X-1 isoform 3
HCLS1-associated protein X-1 (HS1-associating protein X-1) (HAX-1) (HS1-binding protein 1) (HSP1BP-1)
HCLS1 associated protein X-1 isoform 5
HCLS1-associated protein X-1 (HS1-associating protein X-1)
SynonymsHS1BP1
DescriptionFUNCTION: Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex . Slows down the rate of inactivation of KCNC3 channels . Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. .

FUNCTION: Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. .

FUNCTION: Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. .

AccessionsA0A8V8TKG6
ENST00000696932.1 [O00165-1]
ENST00000447768.7 [O00165-6]
ENST00000696944.1
ENST00000435087.2
A0A8V8TLX9
ENST00000532105.1
ENST00000328703.12 [O00165-1]
A0A8V8TLZ3
ENST00000696965.1
ENST00000697830.1 [O00165-3]
A0A8V8TKI6
A0A0S2Z565
ENST00000696933.1
Q5VYD6
A0A8V8TKI8
ENST00000696941.1 [O00165-3]
A0A8V8TKG3
A0A0S2Z591
ENST00000696929.1
A0A0S2Z519
ENST00000696938.1
O00165
ENST00000696945.1
ENST00000483970.7 [O00165-2]
A0A8V8TKH7
ENST00000457918.6 [O00165-5]
ENST00000696966.1
E9PIQ7
ENST00000697592.1 [O00165-3]