I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 43% ± 12% | |
| connective tissue cell | 3 studies | 53% ± 3% | |
| smooth muscle cell | 3 studies | 44% ± 21% | |
| endothelial cell | 3 studies | 33% ± 13% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 43% ± 12% | |
| connective tissue cell | 3 studies | 53% ± 3% | |
| smooth muscle cell | 3 studies | 44% ± 21% | |
| endothelial cell | 3 studies | 33% ± 13% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| liver | 3 studies | 30% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 82% | 95.25 | 147 / 180 | 64% | 11.98 | 274 / 430 |
| intestine | 83% | 173.61 | 805 / 966 | 52% | 4.07 | 274 / 527 |
| stomach | 80% | 64.14 | 287 / 359 | 50% | 4.31 | 142 / 286 |
| thymus | 53% | 32.77 | 348 / 653 | 75% | 10.56 | 451 / 605 |
| esophagus | 47% | 36.30 | 675 / 1445 | 57% | 8.65 | 104 / 183 |
| pancreas | 65% | 32.94 | 213 / 328 | 31% | 2.77 | 55 / 178 |
| skin | 45% | 2255.93 | 807 / 1809 | 50% | 13.24 | 234 / 472 |
| lung | 18% | 9.90 | 105 / 578 | 46% | 5.99 | 533 / 1155 |
| bladder | 24% | 18.19 | 5 / 21 | 34% | 4.74 | 170 / 504 |
| kidney | 51% | 41.13 | 45 / 89 | 5% | 1.00 | 45 / 901 |
| uterus | 21% | 22.34 | 35 / 170 | 33% | 10.38 | 152 / 459 |
| adipose | 46% | 53.65 | 555 / 1204 | 0% | 0 | 0 / 0 |
| breast | 31% | 32.15 | 140 / 459 | 2% | 0.14 | 17 / 1118 |
| blood vessel | 29% | 21.03 | 386 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 29% | 4.31 | 13 / 45 |
| prostate | 22% | 11.56 | 53 / 245 | 0% | 0 | 0 / 502 |
| liver | 3% | 1.62 | 6 / 226 | 7% | 0.80 | 30 / 406 |
| adrenal gland | 0% | 0 | 0 / 258 | 10% | 1.02 | 23 / 230 |
| brain | 5% | 3.05 | 136 / 2642 | 5% | 0.65 | 32 / 705 |
| heart | 8% | 7.41 | 72 / 861 | 0% | 0 | 0 / 0 |
| spleen | 6% | 2.53 | 14 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 4% | 3.05 | 34 / 929 | 0% | 0 | 0 / 0 |
| muscle | 3% | 1.67 | 28 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.08 | 1 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006325 | Biological process | chromatin organization |
| GO_0045869 | Biological process | negative regulation of single stranded viral RNA replication via double stranded DNA intermediate |
| GO_0001837 | Biological process | epithelial to mesenchymal transition |
| GO_0090402 | Biological process | oncogene-induced cell senescence |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_0030261 | Biological process | chromosome condensation |
| GO_0048762 | Biological process | mesenchymal cell differentiation |
| GO_0009615 | Biological process | response to virus |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0002062 | Biological process | chondrocyte differentiation |
| GO_0035988 | Biological process | chondrocyte proliferation |
| GO_0035987 | Biological process | endodermal cell differentiation |
| GO_0043922 | Biological process | negative regulation by host of viral transcription |
| GO_2000648 | Biological process | positive regulation of stem cell proliferation |
| GO_0051301 | Biological process | cell division |
| GO_2000036 | Biological process | regulation of stem cell population maintenance |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0048333 | Biological process | mesodermal cell differentiation |
| GO_0031507 | Biological process | heterochromatin formation |
| GO_0071864 | Biological process | positive regulation of cell proliferation in bone marrow |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0010564 | Biological process | regulation of cell cycle process |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0043392 | Biological process | negative regulation of DNA binding |
| GO_0003131 | Biological process | mesodermal-endodermal cell signaling |
| GO_0048863 | Biological process | stem cell differentiation |
| GO_0006284 | Biological process | base-excision repair |
| GO_2001033 | Biological process | negative regulation of double-strand break repair via nonhomologous end joining |
| GO_0071902 | Biological process | positive regulation of protein serine/threonine kinase activity |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_2000773 | Biological process | negative regulation of cellular senescence |
| GO_0045444 | Biological process | fat cell differentiation |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0071141 | Cellular component | SMAD protein complex |
| GO_0032993 | Cellular component | protein-DNA complex |
| GO_0000228 | Cellular component | nuclear chromosome |
| GO_0035985 | Cellular component | senescence-associated heterochromatin focus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0008301 | Molecular function | DNA binding, bending |
| GO_0051575 | Molecular function | 5'-deoxyribose-5-phosphate lyase activity |
| GO_0003676 | Molecular function | nucleic acid binding |
| GO_0000976 | Molecular function | transcription cis-regulatory region binding |
| GO_0003906 | Molecular function | DNA-(apurinic or apyrimidinic site) endonuclease activity |
| GO_0031492 | Molecular function | nucleosomal DNA binding |
| GO_0046332 | Molecular function | SMAD binding |
| GO_0003714 | Molecular function | transcription corepressor activity |
| GO_0003712 | Molecular function | transcription coregulator activity |
| GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO_0003680 | Molecular function | minor groove of adenine-thymine-rich DNA binding |
| GO_0035500 | Molecular function | MH2 domain binding |
| GO_0070742 | Molecular function | C2H2 zinc finger domain binding |
| GO_0035497 | Molecular function | cAMP response element binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0035501 | Molecular function | MH1 domain binding |
| Gene name | HMGA2 |
| Protein name | High mobility group protein HMGI-C (High mobility group AT-hook protein 2) High mobility group AT-hook 2 HMGA2e |
| Synonyms | HMGIC |
| Description | FUNCTION: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner . . |
| Accessions | ENST00000393578.7 [P52926-6] F5H2U8 ENST00000541363.5 H0YFY4 ENST00000403681.7 [P52926-1] F5H2A4 Q1M183 ENST00000425208.6 [P52926-4] F5H6H0 ENST00000537275.5 [P52926-5] P52926 ENST00000393577.7 ENST00000536545.5 ENST00000354636.7 [P52926-2] ENST00000537429.5 [P52926-3] ENST00000539662.1 |
