GCLC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007584Biological processresponse to nutrient
GO_0045454Biological processcell redox homeostasis
GO_0071333Biological processcellular response to glucose stimulus
GO_0009408Biological processresponse to heat
GO_0071260Biological processcellular response to mechanical stimulus
GO_0032869Biological processcellular response to insulin stimulus
GO_0006534Biological processcysteine metabolic process
GO_0071372Biological processcellular response to follicle-stimulating hormone stimulus
GO_0035729Biological processcellular response to hepatocyte growth factor stimulus
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0051409Biological processresponse to nitrosative stress
GO_0070555Biological processresponse to interleukin-1
GO_0019852Biological processL-ascorbic acid metabolic process
GO_0046685Biological processresponse to arsenic-containing substance
GO_0014823Biological processresponse to activity
GO_1901029Biological processnegative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO_0006750Biological processglutathione biosynthetic process
GO_0097746Biological processblood vessel diameter maintenance
GO_2000490Biological processnegative regulation of hepatic stellate cell activation
GO_0046686Biological processresponse to cadmium ion
GO_0006536Biological processglutamate metabolic process
GO_0009725Biological processresponse to hormone
GO_0043066Biological processnegative regulation of apoptotic process
GO_0051900Biological processregulation of mitochondrial depolarization
GO_0097069Biological processcellular response to thyroxine stimulus
GO_2001237Biological processnegative regulation of extrinsic apoptotic signaling pathway
GO_0044752Biological processresponse to human chorionic gonadotropin
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0006979Biological processresponse to oxidative stress
GO_0044344Biological processcellular response to fibroblast growth factor stimulus
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0005739Cellular componentmitochondrion
GO_0005829Cellular componentcytosol
GO_0017109Cellular componentglutamate-cysteine ligase complex
GO_0043531Molecular functionADP binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0016595Molecular functionglutamate binding
GO_0000287Molecular functionmagnesium ion binding
GO_0005524Molecular functionATP binding
GO_0004357Molecular functionglutamate-cysteine ligase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGCLC
Protein nameGlutamate--cysteine ligase (EC 6.3.2.2) (Gamma-ECS) (Gamma-glutamylcysteine synthetase)
Glutamate-cysteine ligase catalytic subunit
Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase)
SynonymsGLCL
hCG_21942
GLCLC
DescriptionFUNCTION: Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis. .

AccessionsENST00000514004.5
A0A2R8Y648
ENST00000505197.1
A0A0C4DGB2
ENST00000504525.1
ENST00000616923.5
ENST00000650454.1
Q14TF0
E1CEI4
P48506
ENST00000513939.6
D6RIT4
A0A2R8YEL6
D6RGF8
ENST00000509541.5
B4E2I4
ENST00000643939.1