PA2G4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	36 studies	38% ± 14%	Explore
fibroblast	34 studies	33% ± 14%	Explore
CD8-positive, alpha-beta T cell	33 studies	38% ± 19%	Explore
B cell	32 studies	28% ± 9%	Explore
CD4-positive, alpha-beta T cell	30 studies	38% ± 19%	Explore
conventional dendritic cell	29 studies	35% ± 17%	Explore
endothelial cell	28 studies	35% ± 14%	Explore
T cell	26 studies	36% ± 11%	Explore
macrophage	25 studies	29% ± 12%	Explore
pericyte	25 studies	35% ± 10%	Explore
smooth muscle cell	24 studies	34% ± 9%	Explore
regulatory T cell	24 studies	39% ± 16%	Explore
basal cell	21 studies	37% ± 15%	Explore
classical monocyte	21 studies	26% ± 10%	Explore
memory B cell	19 studies	26% ± 11%	Explore
monocyte	18 studies	28% ± 14%	Explore
naive B cell	18 studies	25% ± 7%	Explore
non-classical monocyte	18 studies	28% ± 12%	Explore
mast cell	17 studies	36% ± 13%	Explore
endothelial cell of lymphatic vessel	17 studies	36% ± 9%	Explore
plasmacytoid dendritic cell	17 studies	37% ± 11%	Explore
epithelial cell	17 studies	41% ± 19%	Explore
mature NK T cell	17 studies	34% ± 9%	Explore
gamma-delta T cell	17 studies	39% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	36% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	37% ± 9%	Explore
connective tissue cell	15 studies	33% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	43% ± 11%	Explore
myofibroblast cell	13 studies	35% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	43% ± 14%	Explore
ciliated cell	12 studies	38% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	40% ± 11%	Explore
capillary endothelial cell	12 studies	29% ± 10%	Explore
mucosal invariant T cell	12 studies	35% ± 9%	Explore
endothelial cell of vascular tree	12 studies	36% ± 9%	Explore
myeloid cell	12 studies	34% ± 18%	Explore
plasma cell	11 studies	34% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	38% ± 17%	Explore
vein endothelial cell	11 studies	32% ± 10%	Explore
dendritic cell	10 studies	43% ± 24%	Explore
secretory cell	10 studies	33% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	38% ± 9%	Explore
abnormal cell	10 studies	33% ± 11%	Explore
endothelial cell of artery	10 studies	30% ± 5%	Explore
erythrocyte	10 studies	42% ± 26%	Explore
plasmablast	9 studies	51% ± 23%	Explore
progenitor cell	8 studies	46% ± 16%	Explore
club cell	7 studies	28% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	52% ± 23%	Explore
goblet cell	7 studies	27% ± 9%	Explore
precursor B cell	7 studies	40% ± 18%	Explore
innate lymphoid cell	7 studies	36% ± 10%	Explore
T follicular helper cell	7 studies	28% ± 6%	Explore
type II pneumocyte	6 studies	32% ± 13%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	47% ± 18%	Explore
leukocyte	6 studies	37% ± 11%	Explore
erythroblast	6 studies	58% ± 28%	Explore
mesothelial cell	6 studies	41% ± 15%	Explore
hematopoietic stem cell	6 studies	56% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	45% ± 16%	Explore
alveolar macrophage	5 studies	23% ± 5%	Explore
type I pneumocyte	5 studies	33% ± 11%	Explore
hematopoietic precursor cell	5 studies	61% ± 24%	Explore
exhausted T cell	5 studies	44% ± 16%	Explore
mononuclear phagocyte	5 studies	32% ± 14%	Explore
epithelial cell of proximal tubule	5 studies	26% ± 10%	Explore
intestinal crypt stem cell	5 studies	31% ± 12%	Explore
transit amplifying cell	5 studies	43% ± 14%	Explore
pro-B cell	5 studies	47% ± 18%	Explore
neuron	5 studies	41% ± 14%	Explore
CD4-positive helper T cell	5 studies	38% ± 22%	Explore
granulocyte	5 studies	27% ± 11%	Explore
deuterosomal cell	4 studies	24% ± 7%	Explore
pancreatic A cell	4 studies	38% ± 9%	Explore
kidney loop of Henle epithelial cell	4 studies	25% ± 5%	Explore
enteroendocrine cell	4 studies	38% ± 8%	Explore
immature B cell	4 studies	39% ± 14%	Explore
microglial cell	4 studies	26% ± 11%	Explore
adventitial cell	4 studies	26% ± 7%	Explore
keratinocyte	4 studies	48% ± 9%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	36% ± 4%	Explore
oligodendrocyte precursor cell	4 studies	30% ± 9%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	65% ± 23%	Explore
T-helper 17 cell	4 studies	49% ± 27%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	35% ± 9%	Explore
duct epithelial cell	3 studies	17% ± 1%	Explore
precursor cell	3 studies	60% ± 4%	Explore
respiratory goblet cell	3 studies	30% ± 16%	Explore
type B pancreatic cell	3 studies	37% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	41% ± 16%	Explore
renal alpha-intercalated cell	3 studies	29% ± 10%	Explore
enterocyte	3 studies	24% ± 7%	Explore
neural crest cell	3 studies	54% ± 2%	Explore
extravillous trophoblast	3 studies	40% ± 2%	Explore
placental villous trophoblast	3 studies	54% ± 5%	Explore
common myeloid progenitor	3 studies	42% ± 22%	Explore
lymphocyte	3 studies	54% ± 9%	Explore
megakaryocyte	3 studies	21% ± 2%	Explore
neuroendocrine cell	3 studies	29% ± 7%	Explore
amacrine cell	3 studies	41% ± 13%	Explore
retina horizontal cell	3 studies	32% ± 12%	Explore
serous secreting cell	3 studies	20% ± 7%	Explore
intraepithelial lymphocyte	3 studies	37% ± 12%	Explore
Mueller cell	3 studies	26% ± 5%	Explore
muscle cell	3 studies	34% ± 17%	Explore
germinal center B cell	3 studies	31% ± 10%	Explore
intermediate monocyte	3 studies	41% ± 18%	Explore
myoepithelial cell	3 studies	36% ± 7%	Explore
pancreatic ductal cell	3 studies	47% ± 11%	Explore
granulocyte monocyte progenitor cell	3 studies	49% ± 25%	Explore
glial cell	3 studies	38% ± 22%	Explore
group 3 innate lymphoid cell	3 studies	41% ± 13%	Explore
T-helper 1 cell	3 studies	55% ± 16%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	40% ± 9%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	41% ± 9%	Explore
double negative thymocyte	3 studies	53% ± 18%	Explore
progenitor cell of mammary luminal epithelium	3 studies	28% ± 1%	Explore
hepatocyte	3 studies	36% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	34% ± 13%	Explore
peripheral blood	16 studies	37% ± 11%	Explore
intestine	11 studies	27% ± 12%	Explore
liver	8 studies	32% ± 22%	Explore
kidney	7 studies	28% ± 8%	Explore
brain	6 studies	25% ± 5%	Explore
bone marrow	5 studies	30% ± 10%	Explore
eye	5 studies	27% ± 9%	Explore
lymph node	5 studies	36% ± 11%	Explore
pancreas	4 studies	37% ± 11%	Explore
uterus	4 studies	41% ± 14%	Explore
breast	4 studies	32% ± 7%	Explore
placenta	3 studies	44% ± 5%	Explore
skin	3 studies	40% ± 12%	Explore
prostate	3 studies	35% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	4984.60	258 / 258	100%	70.21	230 / 230
bladder	100%	6018.81	21 / 21	100%	126.83	504 / 504
esophagus	100%	7089.31	1445 / 1445	100%	103.95	183 / 183
intestine	100%	5893.41	966 / 966	100%	127.80	527 / 527
lung	100%	5594.55	578 / 578	100%	90.80	1155 / 1155
ovary	100%	5190.05	180 / 180	100%	117.65	430 / 430
skin	100%	10069.39	1809 / 1809	100%	115.91	472 / 472
stomach	100%	4713.91	359 / 359	100%	113.60	286 / 286
thymus	100%	4815.08	653 / 653	100%	79.15	605 / 605
uterus	100%	5402.94	170 / 170	100%	134.21	459 / 459
prostate	100%	4704.61	245 / 245	100%	82.80	501 / 502
kidney	100%	4213.58	89 / 89	100%	64.31	899 / 901
breast	100%	6112.53	459 / 459	100%	96.70	1115 / 1118
liver	100%	3210.77	225 / 226	100%	61.59	406 / 406
brain	99%	3938.81	2624 / 2642	100%	80.63	705 / 705
pancreas	99%	3889.00	325 / 328	99%	73.39	177 / 178
adipose	100%	6514.60	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5766.78	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	101.93	80 / 80
lymph node	0%	0	0 / 0	100%	147.93	29 / 29
muscle	100%	7154.98	803 / 803	0%	0	0 / 0
spleen	100%	5417.22	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	126.73	45 / 45
ureter	0%	0	0 / 0	100%	93.76	1 / 1
peripheral blood	99%	6562.39	919 / 929	0%	0	0 / 0
heart	97%	4285.85	836 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045597	Biological process	positive regulation of cell differentiation
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0006364	Biological process	rRNA processing
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0006417	Biological process	regulation of translation
GO_0035578	Cellular component	azurophil granule lumen
GO_0005730	Cellular component	nucleolus
GO_0070062	Cellular component	extracellular exosome
GO_1990904	Cellular component	ribonucleoprotein complex
GO_0005576	Cellular component	extracellular region
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0003714	Molecular function	transcription corepressor activity
GO_0005515	Molecular function	protein binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0003676	Molecular function	nucleic acid binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	PA2G4
Protein name	Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1) Proliferation-associated 2G4 PA2G4 protein
Synonyms	EBP1
Description	FUNCTION: May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). .
Accessions	Q05D08 Q6PIN5 Q9UQ80 F8VR77 ENST00000303305.11 [Q9UQ80-1] ENST00000553057.5 ENST00000551061.1 ENST00000552766.5 F8VZ69 F8W0A3

PA2G4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review