MAEL report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MAEL at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MAEL at tissue level.

III. Associated gene sets

GO_0046620Biological processregulation of organ growth
GO_0007283Biological processspermatogenesis
GO_0051093Biological processnegative regulation of developmental process
GO_0007129Biological processhomologous chromosome pairing at meiosis
GO_0071514Biological processgenomic imprinting
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0141007Biological processsiRNA-mediated retrotransposon silencing by heterochromatin formation
GO_0009566Biological processfertilization
GO_0043066Biological processnegative regulation of apoptotic process
GO_0008630Biological processintrinsic apoptotic signaling pathway in response to DNA damage
GO_0031047Biological processregulatory ncRNA-mediated gene silencing
GO_0035234Biological processectopic germ cell programmed cell death
GO_2000242Biological processnegative regulation of reproductive process
GO_0000902Biological processcell morphogenesis
GO_0060964Biological processregulation of miRNA-mediated gene silencing
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0007140Biological processmale meiotic nuclear division
GO_0034587Biological processpiRNA processing
GO_0030849Cellular componentautosome
GO_0071547Cellular componentpiP-body
GO_0043186Cellular componentP granule
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0033391Cellular componentchromatoid body
GO_0005737Cellular componentcytoplasm
GO_0001673Cellular componentmale germ cell nucleus
GO_0000785Cellular componentchromatin
GO_0001741Cellular componentXY body
GO_0005634Cellular componentnucleus
GO_0043565Molecular functionsequence-specific DNA binding

IV. Literature review

[source]
Gene nameMAEL
Protein nameMaelstrom homolog (Drosophila), isoform CRA_c (Maelstrom isoform 3) (Maelstrom spermatogenic transposon silencer)
Protein maelstrom homolog
SynonymshCG_37994
DescriptionFUNCTION: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity). .

FUNCTION: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage. .

FUNCTION: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage. .

AccessionsA0A140VJP0
ENST00000622874.4
ENST00000367872.9 [Q96JY0-1]
ENST00000447624.1
X6RGB1
Q96JY0
E9JVC4
ENST00000367870.6 [Q96JY0-2]