BCL2L1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050673Biological processepithelial cell proliferation
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0007283Biological processspermatogenesis
GO_0006897Biological processendocytosis
GO_0051093Biological processnegative regulation of developmental process
GO_1900118Biological processnegative regulation of execution phase of apoptosis
GO_0001701Biological processin utero embryonic development
GO_1902236Biological processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO_0034097Biological processresponse to cytokine
GO_0001541Biological processovarian follicle development
GO_0032946Biological processpositive regulation of mononuclear cell proliferation
GO_0090201Biological processnegative regulation of release of cytochrome c from mitochondria
GO_0051607Biological processdefense response to virus
GO_0071480Biological processcellular response to gamma radiation
GO_0046898Biological processresponse to cycloheximide
GO_0097048Biological processdendritic cell apoptotic process
GO_0051881Biological processregulation of mitochondrial membrane potential
GO_0051402Biological processneuron apoptotic process
GO_0008637Biological processapoptotic mitochondrial changes
GO_0071312Biological processcellular response to alkaloid
GO_0009566Biological processfertilization
GO_0043066Biological processnegative regulation of apoptotic process
GO_0007281Biological processgerm cell development
GO_0097192Biological processextrinsic apoptotic signaling pathway in absence of ligand
GO_0097284Biological processhepatocyte apoptotic process
GO_0008630Biological processintrinsic apoptotic signaling pathway in response to DNA damage
GO_1902230Biological processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO_0001836Biological processrelease of cytochrome c from mitochondria
GO_0071230Biological processcellular response to amino acid stimulus
GO_2000242Biological processnegative regulation of reproductive process
GO_0071839Biological processapoptotic process in bone marrow cell
GO_0008584Biological processmale gonad development
GO_1902042Biological processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0046902Biological processregulation of mitochondrial membrane permeability
GO_2001240Biological processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0044565Biological processdendritic cell proliferation
GO_2001243Biological processnegative regulation of intrinsic apoptotic signaling pathway
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_2000669Biological processnegative regulation of dendritic cell apoptotic process
GO_0040008Biological processregulation of growth
GO_0035234Biological processectopic germ cell programmed cell death
GO_0032465Biological processregulation of cytokinesis
GO_1903077Biological processnegative regulation of protein localization to plasma membrane
GO_0005739Cellular componentmitochondrion
GO_0005813Cellular componentcentrosome
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_0097136Cellular componentBcl-2 family protein complex
GO_0031965Cellular componentnuclear membrane
GO_0051434Molecular functionBH3 domain binding
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0051400Molecular functionBH domain binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBCL2L1
Protein nameBcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)
Bcl-2-like protein 1
Bcl-2-like protein 1 (Apoptosis regulator Bcl-X)
SynonymsBCLX
BCL2L
hCG_38811
DescriptionFUNCTION: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.; FUNCTION: Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release . .; FUNCTION: Isoform Bcl-X(S) promotes apoptosis.

AccessionsENST00000307677.5 [Q07817-1]
Q5TE64
Q5TE63
A0A0S2Z3C5
ENST00000434194.2 [Q07817-1]
ENST00000420488
Q5QP56
ENST00000678671.1
ENST00000420488.6 [Q07817-1]
ENST00000376055.9 [Q07817-2]
Q5QP59
ENST00000376062.6 [Q07817-1]
ENST00000422920
ENST00000678563.1 [Q07817-1]
ENST00000677194.1 [Q07817-1]
ENST00000450273.2
ENST00000434194
Q9H1R6
A0A7I2V597
ENST00000439267.2 [Q07817-1]
ENST00000456404
ENST00000456404.6 [Q07817-1]
Q07817
ENST00000422920.2 [Q07817-2]
ENST00000676582.1 [Q07817-1]
ENST00000676942.1 [Q07817-1]
ENST00000439267
A0A0S2Z3D2