SH3RF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0051865Biological processprotein autoubiquitination
GO_0016567Biological processprotein ubiquitination
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0043066Biological processnegative regulation of apoptotic process
GO_0030335Biological processpositive regulation of cell migration
GO_0046329Biological processnegative regulation of JNK cascade
GO_0046330Biological processpositive regulation of JNK cascade
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0004864Molecular functionprotein phosphatase inhibitor activity
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0019902Molecular functionphosphatase binding
GO_0008157Molecular functionprotein phosphatase 1 binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameSH3RF2
Protein nameE3 ubiquitin-protein ligase SH3RF2 (EC 2.3.2.27) (Heart protein phosphatase 1-binding protein) (HEPP1) (POSH-eliminating RING protein) (Protein phosphatase 1 regulatory subunit 39) (RING finger protein 158) (RING-type E3 ubiquitin transferase SH3RF2) (SH3 domain-containing RING finger protein 2)
SH3 domain containing ring finger 2
SynonymsPOSH3
RNF158
PPP1R39
POSHER
DescriptionFUNCTION: Has E3 ubiquitin-protein ligase activity . Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation . Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation . Inhibits PPP1CA phosphatase activity . .

AccessionsQ08AM8
ENST00000359120.9 [Q8TEC5-1]
ENST00000511217.1 [Q8TEC5-1]
Q8TEC5