MED1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071364Biological processcellular response to epidermal growth factor stimulus
GO_0031100Biological processanimal organ regeneration
GO_0033148Biological processpositive regulation of intracellular estrogen receptor signaling pathway
GO_0060218Biological processhematopoietic stem cell differentiation
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_0043066Biological processnegative regulation of apoptotic process
GO_0035050Biological processembryonic heart tube development
GO_0045023Biological processG0 to G1 transition
GO_0042789Biological processmRNA transcription by RNA polymerase II
GO_0000902Biological processcell morphogenesis
GO_0045618Biological processpositive regulation of keratinocyte differentiation
GO_0030224Biological processmonocyte differentiation
GO_0035357Biological processperoxisome proliferator activated receptor signaling pathway
GO_0001525Biological processangiogenesis
GO_0060744Biological processmammary gland branching involved in thelarche
GO_0001892Biological processembryonic placenta development
GO_0060750Biological processepithelial cell proliferation involved in mammary gland duct elongation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0051123Biological processRNA polymerase II preinitiation complex assembly
GO_0010628Biological processpositive regulation of gene expression
GO_0071383Biological processcellular response to steroid hormone stimulus
GO_0097067Biological processcellular response to thyroid hormone stimulus
GO_2001141Biological processregulation of RNA biosynthetic process
GO_0010839Biological processnegative regulation of keratinocyte proliferation
GO_0006606Biological processprotein import into nucleus
GO_0045648Biological processpositive regulation of erythrocyte differentiation
GO_0070562Biological processregulation of vitamin D receptor signaling pathway
GO_0048822Biological processenucleate erythrocyte development
GO_0035162Biological processembryonic hemopoiesis
GO_0030216Biological processkeratinocyte differentiation
GO_0016567Biological processprotein ubiquitination
GO_0048821Biological processerythrocyte development
GO_2000347Biological processpositive regulation of hepatocyte proliferation
GO_0003406Biological processretinal pigment epithelium development
GO_0060335Biological processpositive regulation of type II interferon-mediated signaling pathway
GO_0001889Biological processliver development
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006702Biological processandrogen biosynthetic process
GO_0007420Biological processbrain development
GO_0002154Biological processthyroid hormone receptor signaling pathway
GO_0045444Biological processfat cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006590Biological processthyroid hormone generation
GO_0030518Biological processnuclear receptor-mediated steroid hormone signaling pathway
GO_0070318Biological processpositive regulation of G0 to G1 transition
GO_0035729Biological processcellular response to hepatocyte growth factor stimulus
GO_0060745Biological processmammary gland branching involved in pregnancy
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0035116Biological processembryonic hindlimb morphogenesis
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0035855Biological processmegakaryocyte development
GO_0045665Biological processnegative regulation of neuron differentiation
GO_0002088Biological processlens development in camera-type eye
GO_0007595Biological processlactation
GO_0003222Biological processventricular trabecula myocardium morphogenesis
GO_0005634Cellular componentnucleus
GO_0005730Cellular componentnucleolus
GO_0016592Cellular componentmediator complex
GO_0005654Cellular componentnucleoplasm
GO_0016020Cellular componentmembrane
GO_0000785Cellular componentchromatin
GO_0000151Cellular componentubiquitin ligase complex
GO_0070847Cellular componentcore mediator complex
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0001223Molecular functiontranscription coactivator binding
GO_0042975Molecular functionperoxisome proliferator activated receptor binding
GO_0031490Molecular functionchromatin DNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0003682Molecular functionchromatin binding
GO_0042974Molecular functionnuclear retinoic acid receptor binding
GO_0035035Molecular functionhistone acetyltransferase binding
GO_0140296Molecular functiongeneral transcription initiation factor binding
GO_0042809Molecular functionnuclear vitamin D receptor binding
GO_0030374Molecular functionnuclear receptor coactivator activity
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0050693Molecular functionLBD domain binding
GO_0030331Molecular functionnuclear estrogen receptor binding
GO_0005515Molecular functionprotein binding
GO_0046966Molecular functionnuclear thyroid hormone receptor binding
GO_0016922Molecular functionnuclear receptor binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0003712Molecular functiontranscription coregulator activity
GO_0003713Molecular functiontranscription coactivator activity

IV. Literature review

[source]
Gene nameMED1
Protein nameMediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A)
Mediator complex subunit 1
SynonymsCRSP1
DRIP230
PPARBP
DRIP205
CRSP200
TRAP220
RB18A
PPARGBP
TRIP2
PBP
ARC205
DescriptionFUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors . Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells . .

AccessionsQ15648
ENST00000300651.11 [Q15648-1]
J3KSD7
ENST00000581334.1
ENST00000394287.7 [Q15648-3]
J3QKZ7
ENST00000577831.5