MALT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031663Biological processlipopolysaccharide-mediated signaling pathway
GO_0002726Biological processpositive regulation of T cell cytokine production
GO_0042098Biological processT cell proliferation
GO_0045087Biological processinnate immune response
GO_0001923Biological processB-1 B cell differentiation
GO_0009620Biological processresponse to fungus
GO_0051168Biological processnuclear export
GO_0050852Biological processT cell receptor signaling pathway
GO_0043280Biological processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0032743Biological processpositive regulation of interleukin-2 production
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0042981Biological processregulation of apoptotic process
GO_0043066Biological processnegative regulation of apoptotic process
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0042113Biological processB cell activation
GO_0006508Biological processproteolysis
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0051603Biological processproteolysis involved in protein catabolic process
GO_0050856Biological processregulation of T cell receptor signaling pathway
GO_2000321Biological processpositive regulation of T-helper 17 cell differentiation
GO_0006952Biological processdefense response
GO_0002096Cellular componentpolkadots
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0032449Cellular componentCBM complex
GO_0032991Cellular componentprotein-containing complex
GO_0001650Cellular componentfibrillar center
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008233Molecular functionpeptidase activity
GO_0004175Molecular functionendopeptidase activity
GO_0042802Molecular functionidentical protein binding
GO_0036094Molecular functionsmall molecule binding
GO_0002020Molecular functionprotease binding
GO_0019209Molecular functionkinase activator activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMALT1
Protein nameMALT1 paracaspase
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase)
SynonymsMLT
DescriptionFUNCTION: Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines . Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion . Involved in the induction of T helper 17 cells (Th17) differentiation . Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity). Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation . May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity . .

AccessionsENST00000650045.1
ENST00000591792.1
Q9UDY8
A0A3B3IS82
A0A3B3IS32
K7EP42
ENST00000648670.1
ENST00000345724.7 [Q9UDY8-2]
ENST00000649217.2 [Q9UDY8-1]