PRDX3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045454Biological processcell redox homeostasis
GO_0042542Biological processresponse to hydrogen peroxide
GO_0001893Biological processmaternal placenta development
GO_0034614Biological processcellular response to reactive oxygen species
GO_0033554Biological processcellular response to stress
GO_0098869Biological processcellular oxidant detoxification
GO_0042744Biological processhydrogen peroxide catabolic process
GO_0051881Biological processregulation of mitochondrial membrane potential
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0033673Biological processnegative regulation of kinase activity
GO_0034599Biological processcellular response to oxidative stress
GO_0007005Biological processmitochondrion organization
GO_0018171Biological processpeptidyl-cysteine oxidation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0030099Biological processmyeloid cell differentiation
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0006979Biological processresponse to oxidative stress
GO_0032496Biological processresponse to lipopolysaccharide
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0005769Cellular componentearly endosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0043027Molecular functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO_0008379Molecular functionthioredoxin peroxidase activity
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0008785Molecular functionalkyl hydroperoxide reductase activity

IV. Literature review

[source]
Gene namePRDX3
Protein nameThioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Thioredoxin-dependent peroxiredoxin 3)
Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog) (Thioredoxin-dependent peroxiredoxin 3)
SynonymshCG_37898
AOP1
DescriptionFUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides . Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol . Required for the maintenance of physical strength (By similarity). .

AccessionsA0A384MTR2
ENST00000298510.4 [P30048-1]
P30048