LTK report

I. Expression across cell types

Insufficient scRNA-seq data for expression of LTK at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LTK at tissue level.

III. Associated gene sets

GO_0071300Biological processcellular response to retinoic acid
GO_0045664Biological processregulation of neuron differentiation
GO_0008283Biological processcell population proliferation
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0010976Biological processpositive regulation of neuron projection development
GO_0007165Biological processsignal transduction
GO_0007275Biological processmulticellular organism development
GO_0010666Biological processpositive regulation of cardiac muscle cell apoptotic process
GO_0038083Biological processpeptidyl-tyrosine autophosphorylation
GO_0033674Biological processpositive regulation of kinase activity
GO_0043066Biological processnegative regulation of apoptotic process
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0006468Biological processprotein phosphorylation
GO_0042127Biological processregulation of cell population proliferation
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0004714Molecular functiontransmembrane receptor protein tyrosine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0030298Molecular functionreceptor signaling protein tyrosine kinase activator activity

IV. Literature review

[source]
Gene nameLTK
Protein nameLTK protein
Tyrosine-protein kinase receptor (EC 2.7.10.1)
Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1)
SynonymsTYK1
DescriptionFUNCTION: Receptor with a tyrosine-protein kinase activity . Following activation by ALKAL1 or ALKAL2 ligands at the cell surface, transduces an extracellular signal into an intracellular response . Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway . Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (By similarity). The exact function of this protein is not known; studies with chimeric proteins demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival . Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport . .

AccessionsQ4G0N3
ENST00000561619.5
ENST00000263800.11 [P29376-1]
ENST00000453182.2 [P29376-5]
ENST00000355166.9 [P29376-4]
H3BVG6
P29376