RNF157 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_1903861Biological processpositive regulation of dendrite extension
GO_0043066Biological processnegative regulation of apoptotic process
GO_0044297Cellular componentcell body
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameRNF157
Protein nameE3 ubiquitin ligase RNF157 (EC 2.3.2.27) (RING finger protein 157) (RING-type E3 ubiquitin transferase RNF157)
Ring finger protein 157
E3 ubiquitin-protein ligase (EC 2.3.2.27) (RING-type E3 ubiquitin transferase)
SynonymshCG_1817977
KIAA1917
DescriptionFUNCTION: E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons . Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical . May act as a scaffold molecule to regulate this process . Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle . .

FUNCTION: E3 ubiquitin ligase. .

FUNCTION: E3 ubiquitin ligase. .

FUNCTION: E3 ubiquitin ligase. .

FUNCTION: E3 ubiquitin ligase. .

AccessionsK7ENU4
A0A3B3ISM3
ENST00000591615.1
Q9BTC5
ENST00000591355.1
ENST00000319945.10 [Q96PX1-2]
Q96PX1
K7EKB4
ENST00000592271.1
K7ER42
ENST00000269391.11 [Q96PX1-1]
ENST00000647930.1