ERCC5 | OmnibusX

Name	Number of supported studies	Average coverage
CD16-positive, CD56-dim natural killer cell, human	6 studies	18% ± 1%	Explore
regulatory T cell	5 studies	16% ± 1%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	17% ± 2%	Explore
CD8-positive, alpha-beta T cell	4 studies	17% ± 1%	Explore
mucosal invariant T cell	4 studies	17% ± 1%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	17% ± 2%	Explore
gamma-delta T cell	4 studies	19% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	18% ± 2%	Explore
natural killer cell	3 studies	17% ± 1%	Explore
GABAergic neuron	3 studies	20% ± 3%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ERCC5 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
stomach	100%	131.89	359 / 359	70%	1.26	200 / 286
esophagus	100%	147.20	1443 / 1445	68%	1.16	125 / 183
intestine	100%	180.64	966 / 966	60%	1.04	314 / 527
pancreas	100%	122.12	328 / 328	59%	0.88	105 / 178
kidney	100%	115.38	89 / 89	52%	0.94	472 / 901
breast	100%	181.85	459 / 459	47%	0.72	526 / 1118
thymus	100%	210.21	653 / 653	46%	0.68	279 / 605
skin	100%	206.06	1807 / 1809	42%	0.62	199 / 472
prostate	100%	165.33	245 / 245	40%	0.55	203 / 502
bladder	100%	149.43	21 / 21	38%	0.63	190 / 504
brain	94%	84.82	2483 / 2642	43%	0.64	302 / 705
lung	100%	177.15	578 / 578	36%	0.57	414 / 1155
uterus	100%	170.63	170 / 170	30%	0.42	136 / 459
adrenal gland	100%	166.81	258 / 258	26%	0.36	60 / 230
ovary	100%	202.48	180 / 180	18%	0.25	78 / 430
liver	100%	115.60	226 / 226	11%	0.18	44 / 406
adipose	100%	178.20	1204 / 1204	0%	0	0 / 0
spleen	100%	247.42	241 / 241	0%	0	0 / 0
blood vessel	100%	133.99	1332 / 1335	0%	0	0 / 0
muscle	99%	85.73	795 / 803	0%	0	0 / 0
heart	95%	80.60	817 / 861	0%	0	0 / 0
peripheral blood	82%	122.04	764 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	55%	1.12	16 / 29
tonsil	0%	0	0 / 0	29%	0.44	13 / 45
eye	0%	0	0 / 0	24%	0.32	19 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006289	Biological process	nucleotide-excision repair
GO_0006285	Biological process	base-excision repair, AP site formation
GO_0010225	Biological process	response to UV-C
GO_0009411	Biological process	response to UV
GO_0000724	Biological process	double-strand break repair via homologous recombination
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0006283	Biological process	transcription-coupled nucleotide-excision repair
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0000109	Cellular component	nucleotide-excision repair complex
GO_0005662	Cellular component	DNA replication factor A complex
GO_0005634	Cellular component	nucleus
GO_0008047	Molecular function	enzyme activator activity
GO_0042803	Molecular function	protein homodimerization activity
GO_0004519	Molecular function	endonuclease activity
GO_0003697	Molecular function	single-stranded DNA binding
GO_0044877	Molecular function	protein-containing complex binding
GO_0003690	Molecular function	double-stranded DNA binding
GO_0000405	Molecular function	bubble DNA binding
GO_0000993	Molecular function	RNA polymerase II complex binding
GO_0046872	Molecular function	metal ion binding
GO_0004520	Molecular function	DNA endonuclease activity
GO_0005515	Molecular function	protein binding
GO_0003684	Molecular function	damaged DNA binding

IV. Literature review

[source]

Gene name	ERCC5
Protein name	Excision repair cross-complementing rodent repair deficiency, complementation group 5 (Xeroderma pigmentosum, complementation group G (Cockayne syndrome)), isoform CRA_b (Xeroderma pigmentosum complementation group G protein splice variant) ERCC excision repair 5, endonuclease ERCC excision repair 5, endonuclease (ERCC5-201 protein) DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (Xeroderma pigmentosum group G-complementing protein)
Synonyms	XPGC ERCM2 XPG ERCC5-201 hCG_29785
Description	FUNCTION: Single-stranded structure-specific DNA endonuclease involved in DNA excision repair . Makes the 3'incision in DNA nucleotide excision repair (NER) . Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble . Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA . Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes . Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II . Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity . Required for DNA replication fork maintenance and preservation of genomic stability . Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site . During HRR, binds to the replication fork with high specificity and stabilizes it . Also, acts upstream of HRR, to promote the release of BRCA1 from DNA . .
Accessions	A0A494C113 ENST00000652613.1 F2Z2A1 A0A494C0S2 ENST00000651002.1 ENST00000652225.2 [P28715-1] Q9NR54 ENST00000472151.1 A0A090HNM7 P28715 ENST00000651470.1

ERCC5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review