SON | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	53 studies	56% ± 18%	Explore
B cell	48 studies	54% ± 17%	Explore
fibroblast	46 studies	57% ± 16%	Explore
macrophage	43 studies	47% ± 15%	Explore
natural killer cell	43 studies	56% ± 16%	Explore
pericyte	40 studies	60% ± 17%	Explore
T cell	39 studies	50% ± 16%	Explore
CD8-positive, alpha-beta T cell	39 studies	53% ± 16%	Explore
CD4-positive, alpha-beta T cell	35 studies	53% ± 16%	Explore
smooth muscle cell	33 studies	53% ± 15%	Explore
conventional dendritic cell	28 studies	55% ± 15%	Explore
regulatory T cell	28 studies	59% ± 15%	Explore
endothelial cell of lymphatic vessel	27 studies	60% ± 16%	Explore
dendritic cell	26 studies	52% ± 19%	Explore
mast cell	26 studies	50% ± 16%	Explore
classical monocyte	25 studies	53% ± 16%	Explore
non-classical monocyte	24 studies	55% ± 15%	Explore
basal cell	24 studies	52% ± 15%	Explore
plasma cell	23 studies	44% ± 12%	Explore
epithelial cell	23 studies	50% ± 20%	Explore
astrocyte	23 studies	49% ± 19%	Explore
monocyte	22 studies	49% ± 13%	Explore
mature NK T cell	22 studies	53% ± 14%	Explore
plasmacytoid dendritic cell	22 studies	66% ± 16%	Explore
gamma-delta T cell	20 studies	58% ± 18%	Explore
memory B cell	20 studies	63% ± 11%	Explore
naive B cell	20 studies	58% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	19 studies	55% ± 18%	Explore
ciliated cell	19 studies	67% ± 17%	Explore
connective tissue cell	19 studies	55% ± 17%	Explore
microglial cell	19 studies	45% ± 17%	Explore
myeloid cell	18 studies	49% ± 15%	Explore
mucosal invariant T cell	17 studies	55% ± 17%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	56% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	61% ± 15%	Explore
oligodendrocyte	16 studies	42% ± 17%	Explore
capillary endothelial cell	16 studies	53% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	59% ± 14%	Explore
oligodendrocyte precursor cell	15 studies	45% ± 16%	Explore
myofibroblast cell	15 studies	61% ± 14%	Explore
vein endothelial cell	14 studies	53% ± 17%	Explore
endothelial cell of vascular tree	14 studies	53% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	58% ± 19%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	59% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	64% ± 13%	Explore
endothelial cell of artery	13 studies	56% ± 19%	Explore
type I pneumocyte	12 studies	61% ± 15%	Explore
type II pneumocyte	12 studies	51% ± 16%	Explore
innate lymphoid cell	12 studies	55% ± 16%	Explore
plasmablast	12 studies	56% ± 24%	Explore
secretory cell	12 studies	55% ± 17%	Explore
leukocyte	12 studies	49% ± 16%	Explore
mesothelial cell	12 studies	55% ± 14%	Explore
club cell	11 studies	53% ± 14%	Explore
glutamatergic neuron	11 studies	46% ± 22%	Explore
progenitor cell	11 studies	51% ± 18%	Explore
neuron	11 studies	52% ± 17%	Explore
T follicular helper cell	10 studies	60% ± 17%	Explore
GABAergic neuron	10 studies	44% ± 18%	Explore
abnormal cell	10 studies	56% ± 19%	Explore
goblet cell	10 studies	41% ± 20%	Explore
adipocyte	10 studies	58% ± 21%	Explore
retinal rod cell	9 studies	45% ± 18%	Explore
alveolar macrophage	8 studies	45% ± 12%	Explore
respiratory goblet cell	8 studies	54% ± 12%	Explore
platelet	8 studies	34% ± 18%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	56% ± 16%	Explore
kidney loop of Henle epithelial cell	8 studies	40% ± 8%	Explore
renal alpha-intercalated cell	8 studies	48% ± 12%	Explore
amacrine cell	8 studies	47% ± 22%	Explore
neutrophil	7 studies	27% ± 7%	Explore
mononuclear phagocyte	7 studies	50% ± 17%	Explore
kidney distal convoluted tubule epithelial cell	7 studies	51% ± 13%	Explore
epithelial cell of proximal tubule	7 studies	37% ± 12%	Explore
IgG plasma cell	7 studies	29% ± 12%	Explore
retina horizontal cell	7 studies	57% ± 22%	Explore
glial cell	7 studies	45% ± 18%	Explore
retinal cone cell	7 studies	47% ± 26%	Explore
hematopoietic stem cell	7 studies	63% ± 10%	Explore
precursor B cell	7 studies	66% ± 17%	Explore
immature B cell	7 studies	63% ± 12%	Explore
mucus secreting cell	7 studies	36% ± 14%	Explore
erythrocyte	7 studies	50% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	49% ± 14%	Explore
ionocyte	6 studies	59% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	56% ± 16%	Explore
enterocyte	6 studies	34% ± 8%	Explore
transit amplifying cell	6 studies	36% ± 18%	Explore
interneuron	6 studies	51% ± 21%	Explore
retinal ganglion cell	6 studies	64% ± 27%	Explore
lymphocyte	6 studies	55% ± 21%	Explore
cardiac muscle cell	6 studies	48% ± 13%	Explore
Mueller cell	6 studies	55% ± 19%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	67% ± 12%	Explore
hepatocyte	6 studies	50% ± 24%	Explore
CD4-positive helper T cell	5 studies	53% ± 18%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	59% ± 16%	Explore
hematopoietic precursor cell	5 studies	63% ± 16%	Explore
exhausted T cell	5 studies	66% ± 9%	Explore
enteroendocrine cell	5 studies	52% ± 18%	Explore
IgA plasma cell	5 studies	33% ± 9%	Explore
retinal bipolar neuron	5 studies	53% ± 26%	Explore
OFF-bipolar cell	5 studies	42% ± 17%	Explore
ON-bipolar cell	5 studies	44% ± 16%	Explore
renal principal cell	5 studies	43% ± 17%	Explore
erythroblast	5 studies	54% ± 24%	Explore
pro-B cell	5 studies	64% ± 16%	Explore
brush cell	5 studies	46% ± 16%	Explore
T-helper 17 cell	5 studies	55% ± 10%	Explore
group 3 innate lymphoid cell	5 studies	72% ± 12%	Explore
retinal pigment epithelial cell	5 studies	59% ± 19%	Explore
adventitial cell	5 studies	46% ± 15%	Explore
muscle cell	5 studies	53% ± 25%	Explore
double negative thymocyte	5 studies	74% ± 6%	Explore
intermediate monocyte	5 studies	60% ± 20%	Explore
granulocyte	5 studies	49% ± 7%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	41% ± 16%	Explore
deuterosomal cell	4 studies	61% ± 5%	Explore
duct epithelial cell	4 studies	60% ± 4%	Explore
precursor cell	4 studies	58% ± 21%	Explore
squamous epithelial cell	4 studies	45% ± 21%	Explore
pancreatic A cell	4 studies	72% ± 11%	Explore
type B pancreatic cell	4 studies	62% ± 24%	Explore
glomerular endothelial cell	4 studies	68% ± 9%	Explore
podocyte	4 studies	61% ± 19%	Explore
parietal epithelial cell	4 studies	41% ± 11%	Explore
intestinal crypt stem cell	4 studies	30% ± 8%	Explore
granule cell	4 studies	35% ± 12%	Explore
glycinergic amacrine cell	4 studies	30% ± 13%	Explore
Schwann cell	4 studies	55% ± 22%	Explore
chondrocyte	4 studies	56% ± 13%	Explore
endothelial cell of sinusoid	4 studies	33% ± 6%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	58% ± 9%	Explore
myoepithelial cell	4 studies	59% ± 6%	Explore
luminal cell of prostate epithelium	4 studies	34% ± 6%	Explore
keratinocyte	4 studies	41% ± 12%	Explore
hillock cell	3 studies	42% ± 14%	Explore
pancreatic D cell	3 studies	69% ± 18%	Explore
monocyte-derived dendritic cell	3 studies	51% ± 30%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	61% ± 11%	Explore
neural crest cell	3 studies	60% ± 1%	Explore
GABAergic interneuron	3 studies	30% ± 6%	Explore
thymocyte	3 studies	41% ± 16%	Explore
extravillous trophoblast	3 studies	39% ± 10%	Explore
placental villous trophoblast	3 studies	61% ± 6%	Explore
neuroendocrine cell	3 studies	56% ± 24%	Explore
serous secreting cell	3 studies	39% ± 11%	Explore
tissue-resident macrophage	3 studies	55% ± 14%	Explore
intraepithelial lymphocyte	3 studies	57% ± 22%	Explore
rod bipolar cell	3 studies	62% ± 13%	Explore
inflammatory macrophage	3 studies	39% ± 11%	Explore
acinar cell	3 studies	53% ± 22%	Explore
germinal center B cell	3 studies	61% ± 7%	Explore
IgM plasma cell	3 studies	39% ± 17%	Explore
pancreatic ductal cell	3 studies	72% ± 13%	Explore
ependymal cell	3 studies	48% ± 19%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	78% ± 8%	Explore
melanocyte	3 studies	57% ± 10%	Explore
T-helper 1 cell	3 studies	61% ± 7%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	70% ± 2%	Explore
double-positive, alpha-beta thymocyte	3 studies	79% ± 2%	Explore
progenitor cell of mammary luminal epithelium	3 studies	44% ± 8%	Explore
mural cell	3 studies	57% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	21 studies	54% ± 13%	Explore
peripheral blood	20 studies	59% ± 15%	Explore
brain	20 studies	48% ± 17%	Explore
eye	12 studies	53% ± 18%	Explore
intestine	11 studies	44% ± 16%	Explore
kidney	11 studies	46% ± 12%	Explore
heart	7 studies	40% ± 14%	Explore
liver	7 studies	55% ± 17%	Explore
bone marrow	6 studies	43% ± 21%	Explore
lymph node	6 studies	53% ± 16%	Explore
pancreas	5 studies	57% ± 22%	Explore
uterus	5 studies	61% ± 16%	Explore
adipose	5 studies	53% ± 25%	Explore
prostate	5 studies	36% ± 10%	Explore
breast	5 studies	48% ± 16%	Explore
placenta	4 studies	47% ± 13%	Explore
esophagus	4 studies	38% ± 25%	Explore
skin	4 studies	38% ± 13%	Explore
adrenal gland	3 studies	50% ± 12%	Explore
stomach	3 studies	41% ± 21%	Explore
thymus	3 studies	65% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	18311.57	21 / 21	100%	50.42	504 / 504
esophagus	100%	18032.37	1445 / 1445	100%	100.22	183 / 183
ovary	100%	20889.43	180 / 180	100%	50.13	430 / 430
prostate	100%	16625.21	245 / 245	100%	64.15	502 / 502
breast	100%	19178.18	459 / 459	100%	82.99	1117 / 1118
thymus	100%	21317.18	653 / 653	100%	63.51	604 / 605
uterus	100%	21163.98	170 / 170	100%	52.93	458 / 459
lung	100%	19330.43	578 / 578	100%	60.39	1152 / 1155
intestine	100%	18768.09	966 / 966	100%	51.95	525 / 527
stomach	100%	15716.63	359 / 359	99%	64.15	284 / 286
brain	99%	8773.04	2611 / 2642	100%	68.25	705 / 705
skin	100%	17239.54	1809 / 1809	99%	63.35	466 / 472
pancreas	100%	9632.57	327 / 328	99%	50.56	176 / 178
kidney	100%	11124.75	89 / 89	98%	51.24	879 / 901
adrenal gland	100%	17078.02	258 / 258	96%	44.33	220 / 230
liver	100%	7708.00	226 / 226	89%	24.67	360 / 406
adipose	100%	18799.61	1204 / 1204	0%	0	0 / 0
blood vessel	100%	19570.46	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	57.54	29 / 29
muscle	100%	13281.47	803 / 803	0%	0	0 / 0
spleen	100%	21227.20	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	62.69	45 / 45
ureter	0%	0	0 / 0	100%	20.60	1 / 1
heart	99%	11051.82	851 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	93%	34.61	74 / 80
peripheral blood	84%	10031.41	779 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	SON
Protein name	SON protein Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) SON DNA and RNA binding protein SON protein SON3
Synonyms	C21orf50 HSPC310 NREBP DBP5 HSPC312 KIAA1019
Description	FUNCTION: RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 . .
Accessions	H7C2G8 ENST00000457208.5 ENST00000704334.1 H7C257 A0A8Q3SI10 A0JLP4 ENST00000421541.1 H7C1S4 A0A994J4Y9 J3QSZ5 H7C1M2 ENST00000356577.10 [P18583-1] Q3SWV4 ENST00000381679.8 [P18583-6] P18583 Q3YL85 ENST00000429093.6 ENST00000300278.8 [P18583-3] ENST00000695559.1 ENST00000436227.5 ENST00000455528.5 [P18583-4] ENST00000381692.6

GO_0043484	Biological process	regulation of RNA splicing
GO_0008380	Biological process	RNA splicing
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0000281	Biological process	mitotic cytokinesis
GO_0048024	Biological process	regulation of mRNA splicing, via spliceosome
GO_0006397	Biological process	mRNA processing
GO_0051726	Biological process	regulation of cell cycle
GO_0000226	Biological process	microtubule cytoskeleton organization
GO_0016607	Cellular component	nuclear speck
GO_0003677	Molecular function	DNA binding
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

SON report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review