DHRS2 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of DHRS2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	95%	34358.00	20 / 21	61%	291.01	306 / 504
pancreas	98%	575.09	322 / 328	52%	48.16	93 / 178
liver	95%	1151.81	214 / 226	54%	26.76	220 / 406
adrenal gland	56%	75.35	144 / 258	63%	27.03	146 / 230
breast	58%	3621.68	265 / 459	56%	79.11	626 / 1118
ovary	97%	1617.31	174 / 180	15%	2.55	64 / 430
kidney	89%	111.74	79 / 89	12%	12.95	109 / 901
spleen	100%	1998.29	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	252.11	1 / 1
prostate	89%	257.55	218 / 245	10%	1.86	49 / 502
stomach	72%	276.33	260 / 359	21%	3.89	59 / 286
brain	50%	46.50	1318 / 2642	21%	1.65	149 / 705
uterus	25%	27.36	43 / 170	33%	39.06	150 / 459
skin	24%	122.56	441 / 1809	31%	3.10	148 / 472
lung	30%	12.34	176 / 578	16%	6.06	189 / 1155
esophagus	7%	3.06	95 / 1445	22%	17.14	41 / 183
intestine	7%	2.85	68 / 966	17%	3.28	91 / 527
peripheral blood	19%	17.62	177 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	18%	6.87	8 / 45
thymus	4%	4.54	26 / 653	7%	6.35	41 / 605
adipose	10%	5.82	120 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	9%	1.14	7 / 80
blood vessel	2%	5.68	27 / 1335	0%	0	0 / 0
muscle	1%	0.31	7 / 803	0%	0	0 / 0
heart	1%	0.34	6 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0022900	Biological process	electron transport chain
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0034599	Biological process	cellular response to oxidative stress
GO_0008207	Biological process	C21-steroid hormone metabolic process
GO_0009636	Biological process	response to toxic substance
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0043011	Biological process	myeloid dendritic cell differentiation
GO_0005654	Cellular component	nucleoplasm
GO_0005759	Cellular component	mitochondrial matrix
GO_0005635	Cellular component	nuclear envelope
GO_0005737	Cellular component	cytoplasm
GO_0005739	Cellular component	mitochondrion
GO_0005634	Cellular component	nucleus
GO_0004090	Molecular function	carbonyl reductase (NADPH) activity
GO_0005515	Molecular function	protein binding
GO_0016616	Molecular function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Gene name	DHRS2
Protein name	Dehydrogenase/reductase SDR family member 2, mitochondrial (EC 1.1.1.-) (Dicarbonyl reductase HEP27) (Protein D) (Short chain dehydrogenase/reductase family 25C member 1) (Protein SDR25C1) Dehydrogenase/reductase 2
Synonyms	SDR25C1
Description	FUNCTION: NADPH-dependent oxidoreductase which catalyzes the reduction of dicarbonyl compounds. Displays reductase activity in vitro with 3,4-hexanedione, 2,3-heptanedione and 1-phenyl-1,2-propanedione as substrates . May function as a dicarbonyl reductase in the enzymatic inactivation of reactive carbonyls involved in covalent modification of cellular components . Also displays a minor hydroxysteroid dehydrogenase activity toward bile acids such as ursodeoxycholic acid (UDCA) and isoursodeoxycholic acid (isoUDCA), which makes it unlikely to control hormone levels . Doesn't show any activity in vitro with retinoids and sugars as substrates . Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21 . Reduces proliferation, migration and invasion of cancer cells and well as the production of ROS in cancer . .
Accessions	ENST00000611765.4 [Q13268-2] ENST00000250383.11 [Q13268-1] ENST00000557535.5 ENST00000553600.1 Q13268 H0YJG9 C9JZP6 H0YJP4 ENST00000344777.11 [Q13268-2] ENST00000432832.6

DHRS2 report