CRYAA report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CRYAA at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CRYAA at tissue level.

III. Associated gene sets

GO_0002088Biological processlens development in camera-type eye
GO_0007601Biological processvisual perception
GO_0032387Biological processnegative regulation of intracellular transport
GO_0009408Biological processresponse to heat
GO_0043066Biological processnegative regulation of apoptotic process
GO_0050821Biological processprotein stabilization
GO_0042026Biological processprotein refolding
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0051082Molecular functionunfolded protein binding
GO_0005198Molecular functionstructural molecule activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0005212Molecular functionstructural constituent of eye lens
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameCRYAA
Protein nameAlpha-crystallin A chain
Alpha-crystallin A chain (Heat shock protein beta-4) (HspB4) [Cleaved into: Alpha-crystallin A(1-172); Alpha-crystallin A(1-168); Alpha-crystallin A(1-162)]
Alpha crystallin A chain
SynonymsHSPB4
CRYA1
DescriptionFUNCTION: Contributes to the transparency and refractive index of the lens . In its oxidized form (absence of intramolecular disulfide bond), acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions . Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA . .

AccessionsA0A8C8KJZ9
ENST00000291554.6
P02489
ENST00000398132.1
A0A140G952
E7EWH7
Q71V83
A0A140G955
A0A140G954
ENST00000398133.5