DNAJA3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042102Biological processpositive regulation of T cell proliferation
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0071340Biological processskeletal muscle acetylcholine-gated channel clustering
GO_0009408Biological processresponse to heat
GO_0006264Biological processmitochondrial DNA replication
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0033077Biological processT cell differentiation in thymus
GO_0006457Biological processprotein folding
GO_0007005Biological processmitochondrion organization
GO_0043066Biological processnegative regulation of apoptotic process
GO_0007264Biological processsmall GTPase-mediated signal transduction
GO_0006924Biological processactivation-induced cell death of T cells
GO_0090398Biological processcellular senescence
GO_0031594Cellular componentneuromuscular junction
GO_0005739Cellular componentmitochondrion
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0005884Cellular componentactin filament
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0045211Cellular componentpostsynaptic membrane
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005634Cellular componentnucleus
GO_0019901Molecular functionprotein kinase binding
GO_0051082Molecular functionunfolded protein binding
GO_0030695Molecular functionGTPase regulator activity
GO_0030544Molecular functionHsp70 protein binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDNAJA3
Protein nameDnaJ (Hsp40) homolog, subfamily A, member 3 variant (DnaJ (Hsp40) homolog, subfamily A, member 3, isoform CRA_b)
DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog)
DnaJ heat shock protein family (Hsp40) member A3 (DnaJ homolog subfamily A member 3, mitochondrial)
SynonymsTID1
hCG_15165
HCA57
DescriptionFUNCTION: Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.

AccessionsI3L3D3
ENST00000262375.11 [Q96EY1-1]
ENST00000576911.5
Q53G26
ENST00000612103.4 [Q96EY1-1]
ENST00000570857.5
ENST00000355296.8 [Q96EY1-2]
ENST00000633082.1
I3L1T6
ENST00000614397.4 [Q96EY1-2]
ENST00000431375.6 [Q96EY1-3]
ENST00000574895.1
ENST00000575106.5
ENST00000633931.1
Q96EY1
ENST00000631547.1
I3L1T9
ENST00000615114.2
I3L1I6