SOCS3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	35 studies	44% ± 20%	Explore
endothelial cell	34 studies	54% ± 24%	Explore
macrophage	23 studies	34% ± 16%	Explore
classical monocyte	21 studies	39% ± 13%	Explore
pericyte	20 studies	53% ± 25%	Explore
smooth muscle cell	20 studies	46% ± 17%	Explore
CD4-positive, alpha-beta T cell	20 studies	29% ± 10%	Explore
conventional dendritic cell	17 studies	34% ± 11%	Explore
regulatory T cell	17 studies	28% ± 8%	Explore
T cell	16 studies	26% ± 14%	Explore
monocyte	16 studies	40% ± 20%	Explore
capillary endothelial cell	15 studies	39% ± 15%	Explore
endothelial cell of lymphatic vessel	14 studies	47% ± 18%	Explore
endothelial cell of artery	14 studies	42% ± 20%	Explore
endothelial cell of vascular tree	14 studies	57% ± 26%	Explore
basal cell	14 studies	30% ± 11%	Explore
dendritic cell	13 studies	38% ± 14%	Explore
non-classical monocyte	13 studies	35% ± 13%	Explore
connective tissue cell	13 studies	41% ± 18%	Explore
vein endothelial cell	13 studies	47% ± 20%	Explore
plasmacytoid dendritic cell	12 studies	32% ± 13%	Explore
myofibroblast cell	12 studies	39% ± 22%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	29% ± 6%	Explore
myeloid cell	9 studies	37% ± 16%	Explore
ciliated cell	9 studies	34% ± 13%	Explore
type II pneumocyte	8 studies	36% ± 14%	Explore
epithelial cell	7 studies	33% ± 17%	Explore
T follicular helper cell	7 studies	41% ± 24%	Explore
B cell	6 studies	20% ± 2%	Explore
mononuclear phagocyte	6 studies	35% ± 12%	Explore
secretory cell	6 studies	28% ± 8%	Explore
CD8-positive, alpha-beta T cell	6 studies	20% ± 5%	Explore
mast cell	5 studies	21% ± 2%	Explore
plasma cell	5 studies	34% ± 4%	Explore
type I pneumocyte	5 studies	32% ± 10%	Explore
neutrophil	5 studies	34% ± 18%	Explore
mesothelial cell	5 studies	46% ± 28%	Explore
leukocyte	5 studies	32% ± 5%	Explore
monocyte-derived dendritic cell	4 studies	50% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	22% ± 8%	Explore
memory B cell	4 studies	22% ± 7%	Explore
adventitial cell	4 studies	45% ± 18%	Explore
CD4-positive helper T cell	4 studies	24% ± 9%	Explore
gamma-delta T cell	4 studies	20% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	35% ± 14%	Explore
mucosal invariant T cell	4 studies	20% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	38% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	22% ± 4%	Explore
glomerular endothelial cell	3 studies	37% ± 12%	Explore
astrocyte	3 studies	30% ± 2%	Explore
club cell	3 studies	34% ± 12%	Explore
tissue-resident macrophage	3 studies	32% ± 12%	Explore
intermediate monocyte	3 studies	55% ± 25%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	37% ± 10%	Explore
glial cell	3 studies	28% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	14 studies	28% ± 11%	Explore
intestine	7 studies	28% ± 14%	Explore
peripheral blood	6 studies	21% ± 4%	Explore
uterus	6 studies	39% ± 15%	Explore
breast	4 studies	36% ± 5%	Explore
prostate	3 studies	20% ± 5%	Explore
liver	3 studies	27% ± 9%	Explore
lymph node	3 studies	32% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	99%	29949.39	575 / 578	98%	180.10	1134 / 1155
breast	86%	14517.61	396 / 459	88%	86.93	982 / 1118
thymus	87%	7187.58	566 / 653	81%	88.41	490 / 605
kidney	83%	7501.65	74 / 89	84%	131.03	756 / 901
bladder	71%	8340.14	15 / 21	90%	129.12	456 / 504
esophagus	65%	7124.54	933 / 1445	97%	158.07	178 / 183
intestine	69%	11556.15	667 / 966	89%	85.59	467 / 527
stomach	66%	13021.10	236 / 359	91%	94.18	259 / 286
prostate	79%	6134.25	193 / 245	76%	109.47	383 / 502
ovary	55%	6459.11	99 / 180	95%	137.52	410 / 430
skin	64%	4710.02	1163 / 1809	80%	76.75	377 / 472
uterus	45%	5464.56	77 / 170	95%	154.44	436 / 459
pancreas	38%	1694.38	125 / 328	94%	161.75	167 / 178
adrenal gland	67%	4535.07	174 / 258	47%	58.25	109 / 230
liver	60%	5268.15	135 / 226	42%	33.05	170 / 406
tonsil	0%	0	0 / 0	96%	116.01	43 / 45
spleen	90%	6430.60	218 / 241	0%	0	0 / 0
adipose	89%	34921.47	1073 / 1204	0%	0	0 / 0
peripheral blood	82%	10782.33	766 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	79%	105.23	23 / 29
brain	24%	1375.44	641 / 2642	43%	55.88	300 / 705
heart	58%	5112.59	503 / 861	0%	0	0 / 0
blood vessel	58%	7169.29	772 / 1335	0%	0	0 / 0
muscle	18%	1330.01	148 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	3%	1.68	2 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0016567	Biological process	protein ubiquitination
GO_0046426	Biological process	negative regulation of receptor signaling pathway via JAK-STAT
GO_0097398	Biological process	cellular response to interleukin-17
GO_1990830	Biological process	cellular response to leukemia inhibitory factor
GO_0046854	Biological process	phosphatidylinositol phosphate biosynthetic process
GO_0046627	Biological process	negative regulation of insulin receptor signaling pathway
GO_0045597	Biological process	positive regulation of cell differentiation
GO_0035556	Biological process	intracellular signal transduction
GO_0050728	Biological process	negative regulation of inflammatory response
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0060674	Biological process	placenta blood vessel development
GO_0072540	Biological process	T-helper 17 cell lineage commitment
GO_0060670	Biological process	branching involved in labyrinthine layer morphogenesis
GO_0042532	Biological process	negative regulation of tyrosine phosphorylation of STAT protein
GO_0005942	Cellular component	phosphatidylinositol 3-kinase complex
GO_0009898	Cellular component	cytoplasmic side of plasma membrane
GO_0005829	Cellular component	cytosol
GO_0004860	Molecular function	protein kinase inhibitor activity
GO_0046935	Molecular function	1-phosphatidylinositol-3-kinase regulator activity
GO_0030292	Molecular function	protein tyrosine kinase inhibitor activity
GO_0001784	Molecular function	phosphotyrosine residue binding
GO_0035198	Molecular function	miRNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SOCS3
Protein name	Suppressor of cytokine signaling 3 Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Synonyms	SSI3 hCG_1776363 CIS3
Description	FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . .
Accessions	K7EIF6 ENST00000330871.3 O14543 Q6FI39 ENST00000587578.1

SOCS3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review