KIF14 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KIF14 at tissue level.

III. Associated gene sets

GO_0007019Biological processmicrotubule depolymerization
GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0031641Biological processregulation of myelination
GO_0021766Biological processhippocampus development
GO_0021846Biological processcell proliferation in forebrain
GO_0001558Biological processregulation of cell growth
GO_0045184Biological processestablishment of protein localization
GO_0021695Biological processcerebellar cortex development
GO_1903429Biological processregulation of cell maturation
GO_2000045Biological processregulation of G1/S transition of mitotic cell cycle
GO_0051301Biological processcell division
GO_0010389Biological processregulation of G2/M transition of mitotic cell cycle
GO_0021772Biological processolfactory bulb development
GO_0043523Biological processregulation of neuron apoptotic process
GO_0021685Biological processcerebellar granular layer structural organization
GO_0032147Biological processactivation of protein kinase activity
GO_0032487Biological processregulation of Rap protein signal transduction
GO_0043066Biological processnegative regulation of apoptotic process
GO_0034446Biological processsubstrate adhesion-dependent cell spreading
GO_0030334Biological processregulation of cell migration
GO_0007018Biological processmicrotubule-based movement
GO_0033624Biological processnegative regulation of integrin activation
GO_0021693Biological processcerebellar Purkinje cell layer structural organization
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0021987Biological processcerebral cortex development
GO_0030155Biological processregulation of cell adhesion
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0007080Biological processmitotic metaphase chromosome alignment
GO_0032467Biological processpositive regulation of cytokinesis
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0030496Cellular componentmidbody
GO_0005886Cellular componentplasma membrane
GO_0005874Cellular componentmicrotubule
GO_0016020Cellular componentmembrane
GO_0005871Cellular componentkinesin complex
GO_0090543Cellular componentFlemming body
GO_0051233Cellular componentspindle midzone
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0008574Molecular functionplus-end-directed microtubule motor activity
GO_0015631Molecular functiontubulin binding
GO_0019901Molecular functionprotein kinase binding
GO_0030165Molecular functionPDZ domain binding
GO_0003777Molecular functionmicrotubule motor activity
GO_0008017Molecular functionmicrotubule binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameKIF14
Protein nameKinesin-like protein KIF14
SynonymsKIAA0042
DescriptionFUNCTION: Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis . During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively . Regulates cell growth through regulation of cell cycle progression and cytokinesis . During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 . During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process . Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules . .

AccessionsENST00000614960.4
Q15058
ENST00000367350.5