TSC22D1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030511Biological processpositive regulation of transforming growth factor beta receptor signaling pathway
GO_0006366Biological processtranscription by RNA polymerase II
GO_0008284Biological processpositive regulation of cell population proliferation
GO_1902034Biological processnegative regulation of hematopoietic stem cell proliferation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0043066Biological processnegative regulation of apoptotic process
GO_0043065Biological processpositive regulation of apoptotic process
GO_0043068Biological processpositive regulation of programmed cell death
GO_0043069Biological processnegative regulation of programmed cell death
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005739Cellular componentmitochondrion
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003713Molecular functiontranscription coactivator activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTSC22D1
Protein nameTSC22 domain family protein 1 (Cerebral protein 2) (HUCEP-2) (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein)
TSC22 domain family member 1
SynonymsKIAA1994
TSC22
TGFB1I4
hucep-2
DescriptionFUNCTION: Transcriptional repressor . Acts on the C-type natriuretic peptide (CNP) promoter . Acts to promote CASP3-mediated apoptosis . Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 . Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 . Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TFE3 at E-boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade . .; FUNCTION: [Isoform 1]: May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells. .; FUNCTION: [Isoform 2]: Positively regulates cell death in response to TGFB3 during mammary gland involution. .

AccessionsENST00000261489.7 [Q15714-2]
ENST00000493016.1
H7C4J9
ENST00000486464.1
ENST00000611198.4 [Q15714-5]
C9IZ15
ENST00000472477.1
ENST00000622051.1 [Q15714-5]
Q15714
ENST00000458659.3 [Q15714-1]
C9JYW3