FOXE3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FOXE3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FOXE3 at tissue level.

III. Associated gene sets

GO_0050673Biological processepithelial cell proliferation
GO_0006366Biological processtranscription by RNA polymerase II
GO_0061303Biological processcornea development in camera-type eye
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0001654Biological processeye development
GO_0061073Biological processciliary body morphogenesis
GO_1902747Biological processnegative regulation of lens fiber cell differentiation
GO_2001111Biological processpositive regulation of lens epithelial cell proliferation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0030154Biological processcell differentiation
GO_0048468Biological processcell development
GO_0009653Biological processanatomical structure morphogenesis
GO_0042789Biological processmRNA transcription by RNA polymerase II
GO_0002088Biological processlens development in camera-type eye
GO_0061072Biological processiris morphogenesis
GO_0002930Biological processtrabecular meshwork development
GO_0051726Biological processregulation of cell cycle
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity

IV. Literature review

[source]
Gene nameFOXE3
Protein nameForkhead box protein E3 (Forkhead-related protein FKHL12) (Forkhead-related transcription factor 8) (FREAC-8)
Forkhead box protein E3
SynonymsFREAC8
FKHL12
DescriptionFUNCTION: Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle . During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (By similarity). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (By similarity). Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye . .

AccessionsA0A0B5IYB7
A0A0B5J4C4
A0A0B5J149
A0A140F380
A0A140F381
A0A0B5J145
A0A0B5ISY2
A0A0B5IYC4
A0A140F378
A0A0B5IYB0
ENST00000335071.4
A0A0B5ISY9
A0A0B5INR4
A0A0A1EII5
A0A0B5J139
A0A0B5IYA5
A0A0B5J135
A0A0B5J4C1
A0A0B5INR8
A0A0B5ISZ8
A0A0B5J124
A0A0B5J4B6
A0A0B5INS9
A0A140F379
A0A0B5INT4
Q13461
A0A0B5INU1
A0A0B5INR0
A0A0B5ISZ2
A0A0B5J4A8
A0A0B5J129
A0A0B5IYD1