DYRK3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DYRK3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DYRK3 at tissue level.

III. Associated gene sets

GO_1902751Biological processpositive regulation of cell cycle G2/M phase transition
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_1903432Biological processregulation of TORC1 signaling
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0051301Biological processcell division
GO_0035063Biological processnuclear speck organization
GO_0030218Biological processerythrocyte differentiation
GO_0035617Biological processstress granule disassembly
GO_0043066Biological processnegative regulation of apoptotic process
GO_1903008Biological processorganelle disassembly
GO_0080135Biological processregulation of cellular response to stress
GO_0006468Biological processprotein phosphorylation
GO_0043518Biological processnegative regulation of DNA damage response, signal transduction by p53 class mediator
GO_0005856Cellular componentcytoskeleton
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000242Cellular componentpericentriolar material
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0004712Molecular functionprotein serine/threonine/tyrosine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0000287Molecular functionmagnesium ion binding
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameDYRK3
Protein nameDYRK3 protein
dual-specificity kinase (EC 2.7.12.1)
Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1) (Regulatory erythroid kinase) (REDK)
Dual specificity tyrosine phosphorylation regulated kinase 3
Synonyms
DescriptionFUNCTION: Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material . Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues . Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown: acts by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1 . Does not mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus is not regulated by DYRK3 . Dissolution of membraneless organelles at the onset of mitosis is also required to release mitotic regulators, such as ZNF207, from liquid-unmixed organelles where they are sequestered and keep them dissolved during mitosis . Regulates mTORC1 by mediating the dissolution of stress granules: during stressful conditions, DYRK3 partitions from the cytosol to the stress granule, together with mTORC1 components, which prevents mTORC1 signaling . When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol: acts by mediating the phosphorylation of the mTORC1 inhibitor AKT1S1, allowing full reactivation of mTORC1 signaling . Also acts as a negative regulator of EPO-dependent erythropoiesis: may place an upper limit on red cell production during stress erythropoiesis . Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells . Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1: this in turn inhibits p53/TP53 activity and apoptosis . .

AccessionsA0A3B3ISB2
O43781
ENST00000649163.1
ENST00000441486.5
ENST00000367106.1 [O43781-2]
ENST00000367109.8 [O43781-1]
ENST00000367108.7 [O43781-2]
Q4G0U0
Q5SY34