KLHL20 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_1990390Biological processprotein K33-linked ubiquitination
GO_0035455Biological processresponse to interferon-alpha
GO_0007010Biological processcytoskeleton organization
GO_0043066Biological processnegative regulation of apoptotic process
GO_0015031Biological processprotein transport
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0006895Biological processGolgi to endosome transport
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0031463Cellular componentCul3-RING ubiquitin ligase complex
GO_0005794Cellular componentGolgi apparatus
GO_0030425Cellular componentdendrite
GO_0005802Cellular componenttrans-Golgi network
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0019964Molecular functiontype II interferon binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameKLHL20
Protein nameKLHL20 protein (Kelch-like 20 (Drosophila), isoform CRA_a)
Kelch-like protein 20 (Kelch-like ECT2-interacting protein) (Kelch-like protein X)
SynonymshCG_23698
KLEIP
KLHLX
DescriptionFUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis . The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination . Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking . Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 . In case of tumor, the BCR(KLHL20) E3 ubiquitin ligase complex is involved in tumor hypoxia: following hypoxia, the BCR(KLHL20)complex mediates ubiquitination and degradation of PML, potentiating HIF-1 signaling and cancer progression . .

AccessionsENST00000209884.5 [Q9Y2M5-1]
Q9Y2M5
Q9BS75