HIP1R | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte precursor cell	14 studies	52% ± 21%	Explore
oligodendrocyte	12 studies	35% ± 17%	Explore
astrocyte	11 studies	29% ± 14%	Explore
B cell	9 studies	22% ± 7%	Explore
GABAergic neuron	5 studies	24% ± 6%	Explore
naive B cell	5 studies	21% ± 3%	Explore
endothelial cell	4 studies	26% ± 12%	Explore
interneuron	4 studies	25% ± 12%	Explore
neuron	4 studies	29% ± 11%	Explore
epithelial cell	4 studies	25% ± 6%	Explore
brush cell	4 studies	39% ± 10%	Explore
renal principal cell	4 studies	25% ± 4%	Explore
precursor B cell	3 studies	26% ± 2%	Explore
immature B cell	3 studies	26% ± 5%	Explore
glutamatergic neuron	3 studies	34% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	7 studies	29% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	100%	7814.83	328 / 328	100%	44.00	178 / 178
thymus	100%	6472.80	652 / 653	100%	34.95	602 / 605
kidney	100%	10627.78	89 / 89	99%	45.34	892 / 901
brain	100%	10026.39	2641 / 2642	99%	117.57	695 / 705
prostate	99%	5992.40	243 / 245	99%	28.71	498 / 502
breast	100%	6432.21	459 / 459	97%	26.65	1087 / 1118
liver	100%	3419.29	226 / 226	96%	29.94	390 / 406
lung	98%	4278.39	569 / 578	97%	28.12	1120 / 1155
esophagus	91%	2764.99	1317 / 1445	100%	38.09	183 / 183
uterus	95%	2633.93	162 / 170	95%	29.46	436 / 459
stomach	88%	12760.76	316 / 359	99%	36.36	283 / 286
bladder	86%	2894.62	18 / 21	98%	37.60	494 / 504
skin	90%	9471.22	1631 / 1809	86%	20.11	404 / 472
intestine	69%	4062.26	669 / 966	99%	36.24	521 / 527
adrenal gland	100%	5546.82	258 / 258	58%	11.61	134 / 230
ovary	58%	1061.31	104 / 180	73%	11.87	312 / 430
spleen	100%	5614.78	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	29.10	45 / 45
ureter	0%	0	0 / 0	100%	24.89	1 / 1
eye	0%	0	0 / 0	99%	28.17	79 / 80
adipose	99%	4621.74	1187 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	22.58	26 / 29
heart	89%	2796.17	770 / 861	0%	0	0 / 0
blood vessel	82%	3433.78	1092 / 1335	0%	0	0 / 0
peripheral blood	46%	1214.59	427 / 929	0%	0	0 / 0
muscle	27%	474.99	216 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0034316	Biological process	negative regulation of Arp2/3 complex-mediated actin nucleation
GO_0006919	Biological process	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0099173	Biological process	postsynapse organization
GO_0030837	Biological process	negative regulation of actin filament polymerization
GO_1905445	Biological process	positive regulation of clathrin coat assembly
GO_1901030	Biological process	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO_0006897	Biological process	endocytosis
GO_0006898	Biological process	receptor-mediated endocytosis
GO_0032092	Biological process	positive regulation of protein binding
GO_0060453	Biological process	regulation of gastric acid secretion
GO_2000369	Biological process	regulation of clathrin-dependent endocytosis
GO_0055123	Biological process	digestive system development
GO_0045742	Biological process	positive regulation of epidermal growth factor receptor signaling pathway
GO_0048268	Biological process	clathrin coat assembly
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0050821	Biological process	protein stabilization
GO_0007015	Biological process	actin filament organization
GO_0030100	Biological process	regulation of endocytosis
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0032956	Biological process	regulation of actin cytoskeleton organization
GO_2000588	Biological process	positive regulation of platelet-derived growth factor receptor-beta signaling pathway
GO_0032587	Cellular component	ruffle membrane
GO_0016324	Cellular component	apical plasma membrane
GO_0098978	Cellular component	glutamatergic synapse
GO_0005886	Cellular component	plasma membrane
GO_0043197	Cellular component	dendritic spine
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005739	Cellular component	mitochondrion
GO_0097060	Cellular component	synaptic membrane
GO_0030136	Cellular component	clathrin-coated vesicle
GO_0030864	Cellular component	cortical actin cytoskeleton
GO_0043025	Cellular component	neuronal cell body
GO_0005829	Cellular component	cytosol
GO_0014069	Cellular component	postsynaptic density
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005905	Cellular component	clathrin-coated pit
GO_0032839	Cellular component	dendrite cytoplasm
GO_0030665	Cellular component	clathrin-coated vesicle membrane
GO_0042803	Molecular function	protein homodimerization activity
GO_0005547	Molecular function	phosphatidylinositol-3,4,5-trisphosphate binding
GO_0032051	Molecular function	clathrin light chain binding
GO_0005546	Molecular function	phosphatidylinositol-4,5-bisphosphate binding
GO_0051015	Molecular function	actin filament binding
GO_0042802	Molecular function	identical protein binding
GO_0035091	Molecular function	phosphatidylinositol binding
GO_0035615	Molecular function	clathrin adaptor activity
GO_0030276	Molecular function	clathrin binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0080025	Molecular function	phosphatidylinositol-3,5-bisphosphate binding
GO_0005515	Molecular function	protein binding
GO_0043325	Molecular function	phosphatidylinositol-3,4-bisphosphate binding
GO_0017124	Molecular function	SH3 domain binding

Gene name	HIP1R
Protein name	Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12) Huntingtin interacting protein 1 related
Synonyms	HIP12 KIAA0655
Description	FUNCTION: Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. .
Accessions	ENST00000535012.1 H0YH66 O75146 ENST00000253083.9 [O75146-1]

HIP1R report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review