MTDH | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	45 studies	43% ± 14%	Explore
macrophage	43 studies	44% ± 14%	Explore
fibroblast	43 studies	44% ± 13%	Explore
B cell	41 studies	41% ± 12%	Explore
natural killer cell	38 studies	38% ± 11%	Explore
pericyte	37 studies	41% ± 14%	Explore
T cell	35 studies	36% ± 11%	Explore
CD8-positive, alpha-beta T cell	35 studies	40% ± 16%	Explore
CD4-positive, alpha-beta T cell	33 studies	40% ± 14%	Explore
smooth muscle cell	31 studies	39% ± 10%	Explore
conventional dendritic cell	28 studies	61% ± 16%	Explore
classical monocyte	27 studies	50% ± 16%	Explore
dendritic cell	25 studies	51% ± 22%	Explore
mast cell	25 studies	37% ± 15%	Explore
plasma cell	25 studies	55% ± 17%	Explore
endothelial cell of lymphatic vessel	25 studies	43% ± 13%	Explore
regulatory T cell	25 studies	41% ± 11%	Explore
plasmacytoid dendritic cell	24 studies	64% ± 16%	Explore
non-classical monocyte	23 studies	46% ± 14%	Explore
basal cell	22 studies	40% ± 14%	Explore
monocyte	21 studies	46% ± 14%	Explore
epithelial cell	21 studies	43% ± 19%	Explore
mature NK T cell	20 studies	35% ± 9%	Explore
memory B cell	20 studies	45% ± 7%	Explore
ciliated cell	19 studies	41% ± 17%	Explore
naive B cell	19 studies	36% ± 8%	Explore
connective tissue cell	18 studies	45% ± 12%	Explore
astrocyte	18 studies	36% ± 15%	Explore
myeloid cell	18 studies	49% ± 21%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	36% ± 10%	Explore
gamma-delta T cell	17 studies	43% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	39% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	38% ± 13%	Explore
myofibroblast cell	15 studies	44% ± 11%	Explore
endothelial cell of vascular tree	15 studies	36% ± 12%	Explore
oligodendrocyte	14 studies	42% ± 15%	Explore
capillary endothelial cell	14 studies	36% ± 11%	Explore
microglial cell	14 studies	41% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	43% ± 11%	Explore
oligodendrocyte precursor cell	13 studies	38% ± 16%	Explore
vein endothelial cell	13 studies	41% ± 11%	Explore
mucosal invariant T cell	13 studies	38% ± 9%	Explore
type I pneumocyte	12 studies	34% ± 10%	Explore
plasmablast	12 studies	75% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	46% ± 12%	Explore
secretory cell	12 studies	44% ± 11%	Explore
glutamatergic neuron	12 studies	43% ± 24%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	38% ± 13%	Explore
type II pneumocyte	11 studies	38% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	44% ± 13%	Explore
club cell	11 studies	36% ± 11%	Explore
endothelial cell of artery	11 studies	39% ± 12%	Explore
leukocyte	10 studies	41% ± 10%	Explore
GABAergic neuron	10 studies	42% ± 20%	Explore
progenitor cell	10 studies	43% ± 19%	Explore
abnormal cell	10 studies	52% ± 17%	Explore
neuron	10 studies	51% ± 20%	Explore
mesothelial cell	10 studies	40% ± 13%	Explore
goblet cell	9 studies	37% ± 14%	Explore
IgG plasma cell	9 studies	48% ± 14%	Explore
adipocyte	9 studies	32% ± 9%	Explore
alveolar macrophage	8 studies	51% ± 11%	Explore
innate lymphoid cell	8 studies	37% ± 10%	Explore
respiratory goblet cell	8 studies	40% ± 17%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	42% ± 18%	Explore
IgA plasma cell	8 studies	44% ± 12%	Explore
T follicular helper cell	8 studies	41% ± 4%	Explore
retinal rod cell	8 studies	38% ± 12%	Explore
mononuclear phagocyte	7 studies	47% ± 17%	Explore
interneuron	7 studies	45% ± 23%	Explore
hematopoietic stem cell	7 studies	56% ± 12%	Explore
precursor B cell	7 studies	49% ± 18%	Explore
amacrine cell	7 studies	38% ± 16%	Explore
retinal cone cell	7 studies	43% ± 15%	Explore
mucus secreting cell	7 studies	25% ± 4%	Explore
hematopoietic precursor cell	6 studies	65% ± 21%	Explore
ionocyte	6 studies	54% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	45% ± 18%	Explore
transit amplifying cell	6 studies	41% ± 18%	Explore
retinal ganglion cell	6 studies	58% ± 28%	Explore
lymphocyte	6 studies	45% ± 14%	Explore
immature B cell	6 studies	43% ± 14%	Explore
retina horizontal cell	6 studies	35% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	50% ± 14%	Explore
CD4-positive helper T cell	5 studies	32% ± 12%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	35% ± 14%	Explore
exhausted T cell	5 studies	50% ± 14%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	31% ± 9%	Explore
enterocyte	5 studies	26% ± 7%	Explore
enteroendocrine cell	5 studies	39% ± 9%	Explore
glial cell	5 studies	36% ± 16%	Explore
pro-B cell	5 studies	54% ± 16%	Explore
brush cell	5 studies	32% ± 12%	Explore
adventitial cell	5 studies	40% ± 13%	Explore
cardiac muscle cell	5 studies	30% ± 3%	Explore
Mueller cell	5 studies	37% ± 10%	Explore
intermediate monocyte	5 studies	60% ± 17%	Explore
hepatocyte	5 studies	54% ± 21%	Explore
granulocyte	5 studies	39% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	29% ± 6%	Explore
deuterosomal cell	4 studies	25% ± 10%	Explore
duct epithelial cell	4 studies	34% ± 7%	Explore
precursor cell	4 studies	48% ± 9%	Explore
platelet	4 studies	22% ± 6%	Explore
glomerular endothelial cell	4 studies	40% ± 7%	Explore
intestinal crypt stem cell	4 studies	32% ± 10%	Explore
granule cell	4 studies	30% ± 9%	Explore
kidney loop of Henle epithelial cell	4 studies	33% ± 10%	Explore
retinal bipolar neuron	4 studies	36% ± 14%	Explore
retinal pigment epithelial cell	4 studies	42% ± 22%	Explore
OFF-bipolar cell	4 studies	41% ± 20%	Explore
ON-bipolar cell	4 studies	41% ± 19%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	51% ± 5%	Explore
myoepithelial cell	4 studies	43% ± 10%	Explore
luminal cell of prostate epithelium	4 studies	31% ± 11%	Explore
erythrocyte	4 studies	44% ± 19%	Explore
keratinocyte	4 studies	37% ± 8%	Explore
T-helper 17 cell	4 studies	53% ± 18%	Explore
double negative thymocyte	4 studies	48% ± 19%	Explore
hillock cell	3 studies	36% ± 11%	Explore
pancreatic A cell	3 studies	51% ± 7%	Explore
type B pancreatic cell	3 studies	52% ± 15%	Explore
monocyte-derived dendritic cell	3 studies	58% ± 29%	Explore
podocyte	3 studies	44% ± 20%	Explore
epithelial cell of proximal tubule	3 studies	23% ± 6%	Explore
renal alpha-intercalated cell	3 studies	33% ± 10%	Explore
neural crest cell	3 studies	48% ± 1%	Explore
GABAergic interneuron	3 studies	29% ± 4%	Explore
common myeloid progenitor	3 studies	50% ± 26%	Explore
erythroblast	3 studies	64% ± 24%	Explore
megakaryocyte	3 studies	43% ± 1%	Explore
serous secreting cell	3 studies	27% ± 11%	Explore
tissue-resident macrophage	3 studies	42% ± 8%	Explore
GABAergic amacrine cell	3 studies	35% ± 9%	Explore
glycinergic amacrine cell	3 studies	30% ± 7%	Explore
rod bipolar cell	3 studies	43% ± 8%	Explore
germinal center B cell	3 studies	50% ± 3%	Explore
inflammatory macrophage	3 studies	34% ± 8%	Explore
IgM plasma cell	3 studies	62% ± 20%	Explore
muscle cell	3 studies	48% ± 13%	Explore
neural progenitor cell	3 studies	30% ± 8%	Explore
ependymal cell	3 studies	45% ± 17%	Explore
granulocyte monocyte progenitor cell	3 studies	62% ± 25%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	82% ± 12%	Explore
neutrophil	3 studies	29% ± 6%	Explore
chondrocyte	3 studies	38% ± 9%	Explore
group 3 innate lymphoid cell	3 studies	55% ± 11%	Explore
melanocyte	3 studies	37% ± 7%	Explore
T-helper 1 cell	3 studies	55% ± 12%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	37% ± 7%	Explore
progenitor cell of mammary luminal epithelium	3 studies	42% ± 8%	Explore
mural cell	3 studies	39% ± 10%	Explore
renal principal cell	3 studies	27% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	20 studies	42% ± 11%	Explore
brain	20 studies	39% ± 19%	Explore
peripheral blood	19 studies	43% ± 14%	Explore
intestine	11 studies	36% ± 13%	Explore
eye	10 studies	40% ± 12%	Explore
kidney	9 studies	33% ± 13%	Explore
bone marrow	6 studies	42% ± 17%	Explore
liver	6 studies	48% ± 13%	Explore
heart	5 studies	29% ± 5%	Explore
lymph node	5 studies	50% ± 16%	Explore
breast	5 studies	37% ± 12%	Explore
uterus	4 studies	54% ± 13%	Explore
prostate	4 studies	32% ± 10%	Explore
adipose	4 studies	35% ± 6%	Explore
pancreas	3 studies	52% ± 10%	Explore
esophagus	3 studies	41% ± 23%	Explore
skin	3 studies	31% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	5676.00	459 / 459	100%	109.31	1118 / 1118
esophagus	100%	5676.61	1445 / 1445	100%	118.93	183 / 183
intestine	100%	5515.33	966 / 966	100%	84.82	527 / 527
ovary	100%	5688.11	180 / 180	100%	68.90	429 / 430
lung	100%	5529.81	577 / 578	100%	82.86	1154 / 1155
stomach	100%	4115.25	359 / 359	100%	97.83	285 / 286
uterus	100%	6636.98	170 / 170	100%	64.75	457 / 459
liver	100%	6507.41	226 / 226	99%	65.59	403 / 406
bladder	100%	5990.81	21 / 21	99%	69.44	500 / 504
thymus	100%	5474.60	653 / 653	99%	63.30	600 / 605
brain	99%	3458.33	2621 / 2642	100%	54.70	704 / 705
prostate	100%	4608.66	244 / 245	99%	65.66	499 / 502
pancreas	99%	3335.31	325 / 328	99%	61.57	176 / 178
kidney	100%	3058.53	89 / 89	97%	56.65	876 / 901
skin	100%	7603.98	1808 / 1809	96%	80.67	452 / 472
adrenal gland	100%	6098.55	258 / 258	95%	39.99	219 / 230
adipose	100%	6709.62	1204 / 1204	0%	0	0 / 0
blood vessel	100%	7750.91	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	72.06	29 / 29
muscle	100%	6564.24	803 / 803	0%	0	0 / 0
spleen	100%	4605.20	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	63.09	45 / 45
ureter	0%	0	0 / 0	100%	44.22	1 / 1
heart	97%	3593.55	833 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	81%	49.94	65 / 80
peripheral blood	76%	6132.90	709 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0031663	Biological process	lipopolysaccharide-mediated signaling pathway
GO_0045766	Biological process	positive regulation of angiogenesis
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0051092	Biological process	positive regulation of NF-kappaB transcription factor activity
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0010508	Biological process	positive regulation of autophagy
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0016324	Cellular component	apical plasma membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0001650	Cellular component	fibrillar center
GO_0016604	Cellular component	nuclear body
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005737	Cellular component	cytoplasm
GO_0005923	Cellular component	bicellular tight junction
GO_0046581	Cellular component	intercellular canaliculus
GO_0031965	Cellular component	nuclear membrane
GO_0005634	Cellular component	nucleus
GO_0003712	Molecular function	transcription coregulator activity
GO_0061629	Molecular function	RNA polymerase II-specific DNA-binding transcription factor binding
GO_0003723	Molecular function	RNA binding
GO_0003713	Molecular function	transcription coactivator activity
GO_0005515	Molecular function	protein binding
GO_0003725	Molecular function	double-stranded RNA binding
GO_0051059	Molecular function	NF-kappaB binding

IV. Literature review

[source]

Gene name	MTDH
Protein name	Metadherin Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein)
Synonyms	LYRIC AEG1
Description	FUNCTION: Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. .
Accessions	E5RJU9 ENST00000336273.8 H0YBE0 H0YB56 Q86UE4 ENST00000522313.1 ENST00000521933.1 H0YBJ8 ENST00000519293.1 ENST00000519934.5

MTDH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review