SIX4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SIX4 at tissue level.

III. Associated gene sets

GO_0060037Biological processpharyngeal system development
GO_0030238Biological processmale sex determination
GO_0072107Biological processpositive regulation of ureteric bud formation
GO_0007519Biological processskeletal muscle tissue development
GO_0061197Biological processfungiform papilla morphogenesis
GO_0072095Biological processregulation of branch elongation involved in ureteric bud branching
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0046661Biological processmale sex differentiation
GO_0032880Biological processregulation of protein localization
GO_0030910Biological processolfactory placode formation
GO_0061551Biological processtrigeminal ganglion development
GO_0043586Biological processtongue development
GO_0048699Biological processgeneration of neurons
GO_0072075Biological processmetanephric mesenchyme development
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0050678Biological processregulation of epithelial cell proliferation
GO_0034504Biological processprotein localization to nucleus
GO_0048538Biological processthymus development
GO_0090190Biological processpositive regulation of branching involved in ureteric bud morphogenesis
GO_0009653Biological processanatomical structure morphogenesis
GO_0098528Biological processskeletal muscle fiber differentiation
GO_0042472Biological processinner ear morphogenesis
GO_0008584Biological processmale gonad development
GO_0048701Biological processembryonic cranial skeleton morphogenesis
GO_1902725Biological processnegative regulation of satellite cell differentiation
GO_0045214Biological processsarcomere organization
GO_0051451Biological processmyoblast migration
GO_0008582Biological processregulation of synaptic assembly at neuromuscular junction
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0061055Biological processmyotome development
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding

IV. Literature review

[source]
Gene nameSIX4
Protein nameHomeobox protein SIX4 (Sine oculis homeobox homolog 4)
SIX homeobox 4
Synonyms
DescriptionFUNCTION: Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like cell differentiation, cell migration and cell survival. Transactivates gene expression by binding a 5'-[CAT]A[CT][CT][CTG]GA[GAT]-3' motif present in the Trex site and a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 site of the muscle-specific genes enhancer. Acts cooperatively with EYA proteins to transactivate their target genes through interaction and nuclear translocation of EYA protein. Acts synergistically with SIX1 to regulate target genes involved in formation of various organs, including muscle, kidney, gonad, ganglia, olfactory epithelium and cranial skeleton. Plays a role in several important steps of muscle development. Controls the genesis of hypaxial myogenic progenitors in the dermomyotome by transactivating PAX3 and the delamination and migration of the hypaxial precursors from the ventral lip to the limb buds through the transactivation of PAX3, MET and LBX1. Controls myoblast determination by transactivating MYF5, MYOD1 and MYF6. Controls somitic differentiation in myocyte through MYOG transactivation. Plays a role in synaptogenesis and sarcomere organization by participating in myofiber specialization during embryogenesis by activating fast muscle program in the primary myotome resulting in an up-regulation of fast muscle genes, including ATP2A1, MYL1 and TNNT3. Simultaneously, is also able to activate inhibitors of slow muscle genes, such as SOX6, HRASLS, and HDAC4, thereby restricting the activation of the slow muscle genes. During muscle regeneration, negatively regulates differentiation of muscle satellite cells through down-regulation of MYOG expression. During kidney development regulates the early stages of metanephros development and ureteric bud formation through regulation of GDNF, SALL1, PAX8 and PAX2 expression. Plays a role in gonad development by regulating both testis determination and size determination. In gonadal sex determination, transactivates ZFPM2 by binding a MEF3 consensus sequence, resulting in SRY up-regulation. In gonadal size determination, transactivates NR5A1 by binding a MEF3 consensus sequence resulting in gonadal precursor cell formation regulation. During olfactory development mediates the specification and patterning of olfactory placode through fibroblast growth factor and BMP4 signaling pathways and also regulates epithelial cell proliferation during placode formation. Promotes survival of sensory neurons during early trigeminal gangliogenesis. In the developing dorsal root ganglia, up-regulates SLC12A2 transcription. Regulates early thymus/parathyroid organogenesis through regulation of GCM2 and FOXN1 expression. Forms gustatory papillae during development of the tongue. Also plays a role during embryonic cranial skeleton morphogenesis. .

AccessionsENST00000556952.3
Q9UIU6
G3V2N2
ENST00000216513.5