GLO1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	27 studies	25% ± 10%	Explore
fibroblast	21 studies	27% ± 12%	Explore
B cell	16 studies	24% ± 7%	Explore
pericyte	15 studies	26% ± 9%	Explore
smooth muscle cell	15 studies	26% ± 5%	Explore
naive B cell	14 studies	22% ± 4%	Explore
connective tissue cell	13 studies	29% ± 11%	Explore
ciliated cell	12 studies	30% ± 12%	Explore
epithelial cell	11 studies	35% ± 18%	Explore
memory B cell	11 studies	21% ± 3%	Explore
plasmacytoid dendritic cell	10 studies	28% ± 10%	Explore
astrocyte	10 studies	29% ± 13%	Explore
endothelial cell of lymphatic vessel	8 studies	26% ± 5%	Explore
type II pneumocyte	8 studies	28% ± 16%	Explore
CD4-positive, alpha-beta T cell	8 studies	29% ± 15%	Explore
conventional dendritic cell	8 studies	31% ± 13%	Explore
capillary endothelial cell	8 studies	26% ± 9%	Explore
myofibroblast cell	8 studies	28% ± 5%	Explore
plasma cell	8 studies	32% ± 13%	Explore
basal cell	8 studies	26% ± 14%	Explore
CD8-positive, alpha-beta T cell	8 studies	29% ± 17%	Explore
natural killer cell	8 studies	21% ± 6%	Explore
macrophage	6 studies	20% ± 6%	Explore
abnormal cell	6 studies	34% ± 16%	Explore
endothelial cell of artery	6 studies	23% ± 7%	Explore
gamma-delta T cell	6 studies	25% ± 11%	Explore
mucosal invariant T cell	6 studies	18% ± 3%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	27% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	22% ± 9%	Explore
progenitor cell	5 studies	23% ± 8%	Explore
neuron	5 studies	26% ± 13%	Explore
vein endothelial cell	5 studies	23% ± 8%	Explore
retinal cone cell	5 studies	46% ± 19%	Explore
endothelial cell of vascular tree	5 studies	22% ± 1%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	24% ± 8%	Explore
GABAergic neuron	5 studies	28% ± 12%	Explore
oligodendrocyte precursor cell	5 studies	29% ± 7%	Explore
oligodendrocyte	5 studies	21% ± 3%	Explore
regulatory T cell	5 studies	26% ± 7%	Explore
type I pneumocyte	4 studies	27% ± 10%	Explore
hematopoietic precursor cell	4 studies	32% ± 8%	Explore
plasmablast	4 studies	30% ± 15%	Explore
kidney loop of Henle epithelial cell	4 studies	30% ± 5%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	39% ± 6%	Explore
T cell	4 studies	27% ± 14%	Explore
retinal ganglion cell	4 studies	67% ± 26%	Explore
precursor B cell	4 studies	36% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	18% ± 2%	Explore
pro-B cell	4 studies	28% ± 10%	Explore
amacrine cell	4 studies	38% ± 15%	Explore
retina horizontal cell	4 studies	31% ± 11%	Explore
retinal rod cell	4 studies	28% ± 11%	Explore
erythroblast	4 studies	35% ± 19%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	25% ± 3%	Explore
glutamatergic neuron	4 studies	41% ± 16%	Explore
hematopoietic stem cell	4 studies	26% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	33% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	16% ± 1%	Explore
non-classical monocyte	3 studies	24% ± 5%	Explore
glomerular endothelial cell	3 studies	29% ± 7%	Explore
epithelial cell of proximal tubule	3 studies	20% ± 1%	Explore
renal alpha-intercalated cell	3 studies	34% ± 4%	Explore
neural crest cell	3 studies	28% ± 5%	Explore
extravillous trophoblast	3 studies	44% ± 9%	Explore
lymphocyte	3 studies	20% ± 6%	Explore
myeloid cell	3 studies	25% ± 5%	Explore
enterocyte	3 studies	19% ± 2%	Explore
immature B cell	3 studies	23% ± 1%	Explore
mesothelial cell	3 studies	36% ± 20%	Explore
Mueller cell	3 studies	45% ± 7%	Explore
luminal cell of prostate epithelium	3 studies	31% ± 7%	Explore
dendritic cell	3 studies	37% ± 13%	Explore
pancreatic ductal cell	3 studies	56% ± 18%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	52% ± 16%	Explore
enteroendocrine cell	3 studies	25% ± 12%	Explore
intestinal crypt stem cell	3 studies	21% ± 3%	Explore
transit amplifying cell	3 studies	25% ± 4%	Explore
interneuron	3 studies	33% ± 10%	Explore
double negative thymocyte	3 studies	26% ± 13%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	43% ± 20%	Explore
secretory cell	3 studies	25% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	9 studies	28% ± 10%	Explore
peripheral blood	7 studies	19% ± 4%	Explore
eye	7 studies	29% ± 13%	Explore
brain	7 studies	27% ± 8%	Explore
intestine	5 studies	25% ± 12%	Explore
kidney	4 studies	21% ± 4%	Explore
uterus	3 studies	29% ± 15%	Explore
bone marrow	3 studies	26% ± 7%	Explore
liver	3 studies	38% ± 20%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	5439.99	2642 / 2642	100%	212.61	705 / 705
esophagus	100%	4089.08	1445 / 1445	100%	233.15	183 / 183
ovary	100%	6364.98	180 / 180	100%	256.37	430 / 430
prostate	100%	7204.34	245 / 245	100%	666.48	502 / 502
breast	100%	4090.09	459 / 459	100%	284.44	1117 / 1118
bladder	100%	3996.67	21 / 21	100%	201.50	503 / 504
lung	100%	4910.24	577 / 578	100%	223.19	1154 / 1155
stomach	100%	3194.02	359 / 359	100%	196.94	285 / 286
uterus	100%	4517.75	170 / 170	99%	224.36	456 / 459
thymus	100%	3330.63	652 / 653	99%	126.93	599 / 605
liver	100%	3360.60	226 / 226	99%	146.48	400 / 406
intestine	100%	3988.42	966 / 966	98%	201.58	519 / 527
adrenal gland	100%	5121.60	258 / 258	98%	160.93	226 / 230
skin	100%	7101.52	1808 / 1809	98%	216.12	464 / 472
kidney	100%	4404.90	89 / 89	97%	128.09	876 / 901
pancreas	96%	1879.62	315 / 328	99%	115.84	176 / 178
adipose	100%	4039.53	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	144.74	29 / 29
muscle	100%	5890.65	803 / 803	0%	0	0 / 0
spleen	100%	3746.78	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	221.56	45 / 45
ureter	0%	0	0 / 0	100%	122.76	1 / 1
blood vessel	100%	3686.38	1330 / 1335	0%	0	0 / 0
heart	95%	3920.72	822 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	95%	163.91	76 / 80
peripheral blood	65%	2804.86	605 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0005975	Biological process	carbohydrate metabolic process
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0009438	Biological process	methylglyoxal metabolic process
GO_0006749	Biological process	glutathione metabolic process
GO_0030316	Biological process	osteoclast differentiation
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0004462	Molecular function	lactoylglutathione lyase activity
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding

IV. Literature review

[source]

Gene name	GLO1
Protein name	Lactoylglutathione lyase (EC 4.4.1.5) (Glyoxalase I) Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase)
Synonyms	hCG_32350
Description	FUNCTION: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione . Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B . Required for normal osteoclastogenesis (By similarity). . FUNCTION: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. .
Accessions	ENST00000373365.5 [Q04760-1] X5DNM4 Q04760

GLO1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review