Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 20 studies | 31% ± 9% | |
| endothelial cell of artery | 9 studies | 42% ± 14% | |
| capillary endothelial cell | 7 studies | 27% ± 5% | |
| adipocyte | 7 studies | 25% ± 5% | |
| glomerular endothelial cell | 3 studies | 23% ± 2% | |
| endocardial cell | 3 studies | 31% ± 11% |
Insufficient scRNA-seq data for expression of SMAD6 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 4327.01 | 652 / 653 | 95% | 10.67 | 572 / 605 |
| ovary | 95% | 1438.05 | 171 / 180 | 99% | 17.95 | 425 / 430 |
| stomach | 94% | 1156.17 | 338 / 359 | 97% | 10.81 | 277 / 286 |
| intestine | 88% | 858.09 | 850 / 966 | 97% | 8.37 | 511 / 527 |
| prostate | 100% | 1806.95 | 244 / 245 | 80% | 3.53 | 403 / 502 |
| kidney | 99% | 1849.80 | 88 / 89 | 80% | 5.03 | 722 / 901 |
| lung | 99% | 8774.30 | 574 / 578 | 77% | 4.83 | 894 / 1155 |
| bladder | 100% | 2036.48 | 21 / 21 | 75% | 5.95 | 377 / 504 |
| breast | 97% | 1919.45 | 446 / 459 | 72% | 3.02 | 803 / 1118 |
| uterus | 98% | 1432.55 | 166 / 170 | 67% | 4.49 | 309 / 459 |
| esophagus | 72% | 641.92 | 1036 / 1445 | 81% | 8.23 | 149 / 183 |
| pancreas | 49% | 306.84 | 162 / 328 | 91% | 5.94 | 162 / 178 |
| liver | 91% | 908.96 | 205 / 226 | 42% | 2.39 | 170 / 406 |
| brain | 59% | 505.07 | 1567 / 2642 | 51% | 1.71 | 360 / 705 |
| adrenal gland | 69% | 537.06 | 179 / 258 | 34% | 1.52 | 79 / 230 |
| adipose | 100% | 2423.03 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 13.74 | 1 / 1 |
| blood vessel | 100% | 3519.40 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| heart | 100% | 3809.10 | 857 / 861 | 0% | 0 | 0 / 0 |
| skin | 59% | 494.22 | 1075 / 1809 | 33% | 1.53 | 155 / 472 |
| spleen | 79% | 596.93 | 191 / 241 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 53% | 1.75 | 42 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 38% | 1.31 | 17 / 45 |
| muscle | 13% | 77.13 | 108 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.10 | 1 / 29 |
| peripheral blood | 0% | 2.29 | 3 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0030279 | Biological process | negative regulation of ossification |
| GO_0031589 | Biological process | cell-substrate adhesion |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0001657 | Biological process | ureteric bud development |
| GO_0035904 | Biological process | aorta development |
| GO_0003148 | Biological process | outflow tract septum morphogenesis |
| GO_0060392 | Biological process | negative regulation of SMAD protein signal transduction |
| GO_0030512 | Biological process | negative regulation of transforming growth factor beta receptor signaling pathway |
| GO_0043627 | Biological process | response to estrogen |
| GO_0003183 | Biological process | mitral valve morphogenesis |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0003180 | Biological process | aortic valve morphogenesis |
| GO_0060976 | Biological process | coronary vasculature development |
| GO_0003281 | Biological process | ventricular septum development |
| GO_0030514 | Biological process | negative regulation of BMP signaling pathway |
| GO_0032926 | Biological process | negative regulation of activin receptor signaling pathway |
| GO_0030509 | Biological process | BMP signaling pathway |
| GO_0006955 | Biological process | immune response |
| GO_0060395 | Biological process | SMAD protein signal transduction |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0030154 | Biological process | cell differentiation |
| GO_1902895 | Biological process | positive regulation of miRNA transcription |
| GO_0045668 | Biological process | negative regulation of osteoblast differentiation |
| GO_0009653 | Biological process | anatomical structure morphogenesis |
| GO_0003184 | Biological process | pulmonary valve morphogenesis |
| GO_0007352 | Biological process | zygotic specification of dorsal/ventral axis |
| GO_0034616 | Biological process | response to laminar fluid shear stress |
| GO_0007179 | Biological process | transforming growth factor beta receptor signaling pathway |
| GO_0032496 | Biological process | response to lipopolysaccharide |
| GO_0045444 | Biological process | fat cell differentiation |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0016604 | Cellular component | nuclear body |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0071144 | Cellular component | heteromeric SMAD protein complex |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0070412 | Molecular function | R-SMAD binding |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0000976 | Molecular function | transcription cis-regulatory region binding |
| GO_0070698 | Molecular function | type I activin receptor binding |
| GO_0140416 | Molecular function | transcription regulator inhibitor activity |
| GO_0031625 | Molecular function | ubiquitin protein ligase binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0070410 | Molecular function | co-SMAD binding |
| GO_0034713 | Molecular function | type I transforming growth factor beta receptor binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0070411 | Molecular function | I-SMAD binding |
| GO_0140311 | Molecular function | protein sequestering activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SMAD6 |
| Protein name | Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (SMAD family member 6) (SMAD 6) (Smad6) (hSMAD6) SMAD family member 6 Alternative protein SMAD6 |
| Synonyms | MADH6 |
| Description | FUNCTION: Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta . Acts as a mediator of TGF-beta and BMP anti-inflammatory activities. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of pro-inflammatory genes . Blocks the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding . Binds to regulatory elements in target promoter regions . . |
| Accessions | H0YK80 L8E6S0 ENST00000558937.1 O43541 ENST00000557916.5 [O43541-4] ENST00000288840.10 [O43541-1] ENST00000559931.5 H0YM33 |
