PLK1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLK1 at tissue level.

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0016567Biological processprotein ubiquitination
GO_1905784Biological processregulation of anaphase-promoting complex-dependent catabolic process
GO_0007062Biological processsister chromatid cohesion
GO_0030071Biological processregulation of mitotic metaphase/anaphase transition
GO_0000278Biological processmitotic cell cycle
GO_0090435Biological processprotein localization to nuclear envelope
GO_0045862Biological processpositive regulation of proteolysis
GO_0000070Biological processmitotic sister chromatid segregation
GO_0045143Biological processhomologous chromosome segregation
GO_0007052Biological processmitotic spindle organization
GO_0006302Biological processdouble-strand break repair
GO_0045184Biological processestablishment of protein localization
GO_0051443Biological processpositive regulation of ubiquitin-protein transferase activity
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_1901673Biological processregulation of mitotic spindle assembly
GO_0007091Biological processmetaphase/anaphase transition of mitotic cell cycle
GO_0097681Biological processdouble-strand break repair via alternative nonhomologous end joining
GO_0000132Biological processestablishment of mitotic spindle orientation
GO_0007077Biological processmitotic nuclear membrane disassembly
GO_0000281Biological processmitotic cytokinesis
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0031648Biological processprotein destabilization
GO_0043393Biological processregulation of protein binding
GO_0048313Biological processGolgi inheritance
GO_1904776Biological processregulation of protein localization to cell cortex
GO_0007098Biological processcentrosome cycle
GO_0007095Biological processmitotic G2 DNA damage checkpoint signaling
GO_1904668Biological processpositive regulation of ubiquitin protein ligase activity
GO_0016321Biological processfemale meiosis chromosome segregation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0007346Biological processregulation of mitotic cell cycle
GO_0051081Biological processnuclear membrane disassembly
GO_1900182Biological processpositive regulation of protein localization to nucleus
GO_0071168Biological processprotein localization to chromatin
GO_0007076Biological processmitotic chromosome condensation
GO_0000086Biological processG2/M transition of mitotic cell cycle
GO_0070194Biological processsynaptonemal complex disassembly
GO_0006468Biological processprotein phosphorylation
GO_0007094Biological processmitotic spindle assembly checkpoint signaling
GO_1901990Biological processregulation of mitotic cell cycle phase transition
GO_0010800Biological processpositive regulation of peptidyl-threonine phosphorylation
GO_0045736Biological processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0001578Biological processmicrotubule bundle formation
GO_2000042Biological processnegative regulation of double-strand break repair via homologous recombination
GO_0051726Biological processregulation of cell cycle
GO_0032465Biological processregulation of cytokinesis
GO_0097431Cellular componentmitotic spindle pole
GO_0005876Cellular componentspindle microtubule
GO_0000795Cellular componentsynaptonemal complex
GO_0030496Cellular componentmidbody
GO_0034451Cellular componentcentriolar satellite
GO_0000922Cellular componentspindle pole
GO_0005813Cellular componentcentrosome
GO_0000776Cellular componentkinetochore
GO_0005654Cellular componentnucleoplasm
GO_0005814Cellular componentcentriole
GO_0051233Cellular componentspindle midzone
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0000940Cellular componentouter kinetochore
GO_0000785Cellular componentchromatin
GO_0005819Cellular componentspindle
GO_0005634Cellular componentnucleus
GO_0010997Molecular functionanaphase-promoting complex binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0000287Molecular functionmagnesium ion binding
GO_0004672Molecular functionprotein kinase activity
GO_0008017Molecular functionmicrotubule binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePLK1
Protein nameSerine/threonine-protein kinase PLK1 (Polo-like kinase 1)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
SynonymsPLK
DescriptionFUNCTION: Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis . Polo-like kinase proteins act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains . Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, POLQ, PRC1, RACGAP1/CYK4, RAD51, RHNO1, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU . Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL . NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation . Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins . Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1 . Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains . Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation . Promotes the central spindle recruitment of ECT2 . Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1 . Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1 . Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase . Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity . Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2 . PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation . Required for kinetochore localization of BUB1B . Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2 (By similarity). Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function . Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome . Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53 . Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA . Contributes to the regulation of AURKA function . Also required for recovery after DNA damage checkpoint and entry into mitosis . Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning . Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation . Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope . Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock . Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression . Regulates mitotic progression by phosphorylating RIOK2 . Through the phosphorylation of DZIP1 regulates the localization during mitosis of the BBSome, a ciliary protein complex involved in cilium biogenesis . Regulates DNA repair during mitosis by mediating phosphorylation of POLQ and RHNO1, thereby promoting POLQ recruitment to DNA damage sites . .

AccessionsENST00000300093.9
ENST00000567897.6
P53350
I3L309
ENST00000568568.1
I3L2H5
I3L387
ENST00000570220.5