I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| placental villous trophoblast | 3 studies | 33% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| placental villous trophoblast | 3 studies | 33% ± 4% |
Insufficient scRNA-seq data for expression of MSX2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| bladder | 100% | 1041.52 | 21 / 21 | 84% | 39.60 | 422 / 504 |
| breast | 89% | 313.44 | 408 / 459 | 82% | 22.75 | 913 / 1118 |
| esophagus | 69% | 73.57 | 1002 / 1445 | 83% | 14.75 | 152 / 183 |
| skin | 100% | 466.14 | 1808 / 1809 | 50% | 5.34 | 235 / 472 |
| prostate | 96% | 207.46 | 236 / 245 | 45% | 3.41 | 227 / 502 |
| stomach | 51% | 42.09 | 182 / 359 | 87% | 22.84 | 249 / 286 |
| intestine | 51% | 43.68 | 494 / 966 | 81% | 20.97 | 427 / 527 |
| uterus | 72% | 95.14 | 123 / 170 | 53% | 18.31 | 244 / 459 |
| lung | 60% | 56.17 | 348 / 578 | 42% | 6.35 | 487 / 1155 |
| ureter | 0% | 0 | 0 / 0 | 100% | 12.46 | 1 / 1 |
| muscle | 92% | 93.12 | 737 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 90% | 430.53 | 1197 / 1335 | 0% | 0 | 0 / 0 |
| pancreas | 10% | 5.35 | 32 / 328 | 77% | 12.80 | 137 / 178 |
| heart | 81% | 83.10 | 698 / 861 | 0% | 0 | 0 / 0 |
| adipose | 80% | 87.41 | 958 / 1204 | 0% | 0 | 0 / 0 |
| brain | 45% | 100.83 | 1194 / 2642 | 30% | 5.14 | 209 / 705 |
| spleen | 65% | 64.13 | 156 / 241 | 0% | 0 | 0 / 0 |
| thymus | 43% | 31.16 | 281 / 653 | 2% | 0.14 | 15 / 605 |
| ovary | 8% | 5.43 | 14 / 180 | 20% | 2.92 | 86 / 430 |
| adrenal gland | 11% | 6.15 | 28 / 258 | 10% | 0.82 | 24 / 230 |
| lymph node | 0% | 0 | 0 / 0 | 21% | 2.00 | 6 / 29 |
| eye | 0% | 0 | 0 / 0 | 20% | 1.13 | 16 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 16% | 1.45 | 7 / 45 |
| kidney | 4% | 2.70 | 4 / 89 | 6% | 0.66 | 58 / 901 |
| liver | 0% | 0.19 | 1 / 226 | 4% | 0.35 | 17 / 406 |
| peripheral blood | 0% | 0.05 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0060346 | Biological process | bone trabecula formation |
| GO_0003161 | Biological process | cardiac conduction system development |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0003198 | Biological process | epithelial to mesenchymal transition involved in endocardial cushion formation |
| GO_0003148 | Biological process | outflow tract septum morphogenesis |
| GO_0035880 | Biological process | embryonic nail plate morphogenesis |
| GO_0060444 | Biological process | branching involved in mammary gland duct morphogenesis |
| GO_0001649 | Biological process | osteoblast differentiation |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0051795 | Biological process | positive regulation of timing of catagen |
| GO_0045599 | Biological process | negative regulation of fat cell differentiation |
| GO_0071392 | Biological process | cellular response to estradiol stimulus |
| GO_0061311 | Biological process | cell surface receptor signaling pathway involved in heart development |
| GO_0097152 | Biological process | mesenchymal cell apoptotic process |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0045669 | Biological process | positive regulation of osteoblast differentiation |
| GO_0035115 | Biological process | embryonic forelimb morphogenesis |
| GO_0035116 | Biological process | embryonic hindlimb morphogenesis |
| GO_0090427 | Biological process | activation of meiosis |
| GO_0002063 | Biological process | chondrocyte development |
| GO_0023019 | Biological process | signal transduction involved in regulation of gene expression |
| GO_0030509 | Biological process | BMP signaling pathway |
| GO_0045617 | Biological process | negative regulation of keratinocyte differentiation |
| GO_0060364 | Biological process | frontal suture morphogenesis |
| GO_0048598 | Biological process | embryonic morphogenesis |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0060363 | Biological process | cranial suture morphogenesis |
| GO_0030513 | Biological process | positive regulation of BMP signaling pathway |
| GO_0009952 | Biological process | anterior/posterior pattern specification |
| GO_0070166 | Biological process | enamel mineralization |
| GO_0048863 | Biological process | stem cell differentiation |
| GO_2001055 | Biological process | positive regulation of mesenchymal cell apoptotic process |
| GO_0035313 | Biological process | wound healing, spreading of epidermal cells |
| GO_0002076 | Biological process | osteoblast development |
| GO_0003416 | Biological process | endochondral bone growth |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0016607 | Cellular component | nuclear speck |
| GO_0005829 | Cellular component | cytosol |
| GO_0000785 | Cellular component | chromatin |
| GO_0005667 | Cellular component | transcription regulator complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0000977 | Molecular function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| GO_0001227 | Molecular function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0043565 | Molecular function | sequence-specific DNA binding |
| GO_0000976 | Molecular function | transcription cis-regulatory region binding |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | MSX2 |
| Protein name | Homeobox protein MSX-2 (Homeobox protein Hox-8) Msh homeobox 2 |
| Synonyms | HOX8 |
| Description | FUNCTION: Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. . |
| Accessions | ENST00000507785.2 P35548 ENST00000239243.7 D6RIS4 |
