GDNF report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GDNF at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GDNF at tissue level.

III. Associated gene sets

GO_0061642Biological processchemoattraction of axon
GO_0033603Biological processpositive regulation of dopamine secretion
GO_0010468Biological processregulation of gene expression
GO_0001658Biological processbranching involved in ureteric bud morphogenesis
GO_0048568Biological processembryonic organ development
GO_0072107Biological processpositive regulation of ureteric bud formation
GO_0001759Biological processorgan induction
GO_0032770Biological processpositive regulation of monooxygenase activity
GO_0048485Biological processsympathetic nervous system development
GO_0001755Biological processneural crest cell migration
GO_0051584Biological processregulation of dopamine uptake involved in synaptic transmission
GO_2000736Biological processregulation of stem cell differentiation
GO_0060688Biological processregulation of morphogenesis of a branching structure
GO_0031175Biological processneuron projection development
GO_0001656Biological processmetanephros development
GO_0007165Biological processsignal transduction
GO_0008344Biological processadult locomotory behavior
GO_0035860Biological processglial cell-derived neurotrophic factor receptor signaling pathway
GO_0021516Biological processdorsal spinal cord development
GO_0021784Biological processpostganglionic parasympathetic fiber development
GO_0048255Biological processmRNA stabilization
GO_2001260Biological processregulation of semaphorin-plexin signaling pathway
GO_0001941Biological processpostsynaptic membrane organization
GO_0060676Biological processureteric bud formation
GO_0071679Biological processcommissural neuron axon guidance
GO_0072108Biological processpositive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO_0045597Biological processpositive regulation of cell differentiation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0007422Biological processperipheral nervous system development
GO_0090190Biological processpositive regulation of branching involved in ureteric bud morphogenesis
GO_0008284Biological processpositive regulation of cell population proliferation
GO_2001240Biological processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0007399Biological processnervous system development
GO_0003337Biological processmesenchymal to epithelial transition involved in metanephros morphogenesis
GO_0030432Biological processperistalsis
GO_0048484Biological processenteric nervous system development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005794Cellular componentGolgi apparatus
GO_0042803Molecular functionprotein homodimerization activity
GO_0030116Molecular functionglial cell-derived neurotrophic factor receptor binding
GO_0005102Molecular functionsignaling receptor binding
GO_0008083Molecular functiongrowth factor activity
GO_1902379Molecular functionchemoattractant activity involved in axon guidance
GO_0005515Molecular functionprotein binding
GO_0030971Molecular functionreceptor tyrosine kinase binding

IV. Literature review

[source]
Gene nameGDNF
Protein nameGlial cell line-derived neurotrophic factor (hGDNF) (Astrocyte-derived trophic factor) (ATF)
Glial cell line-derived neurotrophic factor
Glial cell derived neurotrophic factor isoform 2
Glial cell derived neurotrophic factor
Synonyms
DescriptionFUNCTION: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. .

AccessionsENST00000344622.8 [P39905-2]
ENST00000427982.5 [P39905-3]
ENST00000502572.1
ENST00000620847.1 [P39905-5]
ENST00000381826.8 [P39905-4]
ENST00000515058.5 [P39905-2]
P39905
A0A0S2Z3V2
A0A0S2Z3T2
ENST00000326524.7 [P39905-1]
A0A0C4DGC2
ENST00000510177.5