HSPB6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009408Biological processresponse to heat
GO_0043066Biological processnegative regulation of apoptotic process
GO_0061077Biological processchaperone-mediated protein folding
GO_0042026Biological processprotein refolding
GO_0045766Biological processpositive regulation of angiogenesis
GO_0016607Cellular componentnuclear speck
GO_0005829Cellular componentcytosol
GO_0005576Cellular componentextracellular region
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0044183Molecular functionprotein folding chaperone
GO_0042803Molecular functionprotein homodimerization activity
GO_0051082Molecular functionunfolded protein binding
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0005212Molecular functionstructural constituent of eye lens

IV. Literature review

[source]
Gene nameHSPB6
Protein nameHeat shock protein family B (small) member 6
Heat shock protein beta-6 (HspB6) (Heat shock 20 kDa-like protein p20)
Synonyms
DescriptionFUNCTION: Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity. .

AccessionsENST00000592984.6
A0A1X7SC65
K7EP04
ENST00000004982.6
O14558
ENST00000587965.1